Identification of Immune Candidate Genes in Post-Sepsis Syndrome: Linking Innate Immunity to Long-Term Autoimmune Responses [0.03%]
脓毒症后综合征免疫候选基因的鉴定：连接先天免疫与长期自身免疫反应
Yuying Zhou,Tingjun Wang,Yecheng Li et al.
Yuying Zhou et al.
Introduction: Post-Sepsis Syndrome (PSS) is marked by persistent immune dysregulation, leading to long-term complications that overlap with autoimmune responses. Uncovering key immune-related candidate genes during PSS re...
Differential Recognition of Lipopolysaccharide O-Antigens by the Pattern Recognition Molecules MBL and Ficolins of the Complement System [0.03%]
补体系统模式识别分子MBL和Fc联合蛋白对脂多糖O-抗原的不同识别作用
Kirstine Mejlstrup Hymøller,Lisa Crone,Steffen Thiel et al.
Kirstine Mejlstrup Hymøller et al.
Introduction: The complement system plays a crucial role in bridging innate and adaptive immune responses. When activated, a proteolytic cascade leads to pathogen destruction. It is initiated via the recognition of foreig...
Oxidative stress and chronic inflammation as partners in crime in interstitial cystitis/bladder pain syndrome [0.03%]
氧化应激与慢性炎症在间质性膀胱炎/膀胱疼痛综合征中的罪魁祸首作用
Aleksandar Janev,Daša Zupančič,Peter Veranič et al.
Aleksandar Janev et al.
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory disease of the urinary bladder, characterized by chronic pain, increased urinary frequency, urgency, and nocturia. Currently, no therapeutic option consistently ...
TLR9 Downregulation in Breast Cancer: Its Role in Tumor Immunity, Inflammatory Response, and Cellular Senescence [0.03%]
乳腺癌中TLR9的下调：其在肿瘤免疫、炎症反应和细胞衰老中的作用
Emily Sible,Gregory Weitsman,Salome Amouyal et al.
Emily Sible et al.
Toll-like receptor 9 (TLR9) is primarily expressed in human dendritic and B cells and recognizes double-stranded DNA motifs from pathogens to initiate an inflammatory response. Recent studies have revealed TLR9's involvement beyond its conv...
Interaction Between Group 3 Innate Lymphoid Cells, Microbiota, and Intestinal Diseases: Mechanisms and Therapeutic Potential [0.03%]
3型固有淋巴细胞与肠道菌群及肠病的相互作用：机制和治疗潜能
Lijie Hao,Yi Ge,Zhuo Chen et al.
Lijie Hao et al.
Background: The incidence of intestinal diseases is increasing every year, placing a heavy burden on the world's health and economy. The interaction of immune, microbial, and environmental factors leading to chronic infla...
Published Erratum
Journal of innate immunity. 2025;17(1):287. DOI:10.1159/000545776 2025
Emerging advancements in metabolic properties of macrophages within disease microenvironment for immune therapy [0.03%]
疾病微环境中免疫疗法下巨噬细胞代谢特性的新进展
Feng Zhao,Zhongyu Yue,Lijiaqi Zhang et al.
Feng Zhao et al.
Background: As sentinel cells of innate immunity, macrophages exhibit microenvironment-driven functional plasticity critical for immune regulation and tissue homeostasis, yet maladaptive metabolic reprogramming-induced po...
TLR2 or TLR4 stimulation induces transmembrane (tm)TNF-driven priming in macrophages which results in improved clearance of a subsequent Staphylococcus aureus infection [0.03%]
TLR2或TLR4刺激可使巨噬细胞产生肿瘤坏死因子改善对金黄色葡萄球菌的后续清除作用
Abby M Luu,Alexis A Hatton,Jasper Gattiker et al.
Abby M Luu et al.
Introduction: Toll-like receptor (TLR) engagement on macrophages can improve responsiveness to infection. TNF is upregulated following TLR2 or TLR4 stimulation. We sought to determine whether and how the two bioactive for...
Patients Hospitalized with COVID-19 Demonstrate Distinct Plasma Cytokine and Chemokine Concentrations in vivo and TLR-mediated Cytokine and Chemokine Production in Whole Blood in vitro [0.03%]
住院的COVID-19患者体内和体外活血中具有不同的细胞因子和化学因子浓度及TLR介导的细胞因子和化学因子产生量
Athena N Nguyen,Thomas S Kouyate,Kevin Ryff et al.
Athena N Nguyen et al.
Introduction: SARS-CoV-2's continued global health impact underscores the importance of ongoing pathogenesis research. Insights into the host's first line of defense against severe COVID-19 identify actionable biomarkers,...
Interactions of Probiotics with the Immune Cells of Patients with COVID-19 Pneumonia [0.03%]
益生菌与新型冠状病毒肺炎患者免疫细胞间的相互作用
Ioannis Mitrou,George Dimopoulos,Konstantina Dakou et al.
Ioannis Mitrou et al.
Introduction: In severe COVID-19, excessive cytokine release may be driven by SARS-CoV-2. We investigated the modulatory effect of probiotics taking into consideration direct interaction with the immune gut cells. ...