FCGR3A Drives Innate Immune Activation via M1 Macrophage Polarization in Pediatric IBD [0.03%]
儿童IBD中通过M1型巨噬细胞极化驱动固有免疫活化的FCGR3A
Xi Liu,Zhishan Liang
Xi Liu
Objective: This study investigated the role of FCGR3A in pediatric inflammatory bowel disease (IBD) through integrated transcriptomic analysis and experimental validation, aiming to provide new mechanistic insights and th...
Target based biofilm inhibition and antibiotic enhancement strategy by miR.101.3p using DNA tetrahedrons [0.03%]
基于DNA四面体的miR.101.3p生物膜靶向抑制及抗生素增效策略研究
Yin He Richard Sun,Yun Fei Ye,Hawraa Shahrour et al.
Yin He Richard Sun et al.
Cystic Fibrosis is an inherited disease caused by mutations in the CF transmembrane conductance regulator gene. It is characterized by progressive decline in lung function, often driven by chronic respiratory infections, particularly with S...
Circulating Plasmacytoid Dendritic Cells are Numerically and Functionally Deficient in Trauma Patients [0.03%]
创伤患者的循环浆细胞样树突状细胞数量不足且功能受损
Ki-Jeong Park,Hye-Mi Jin,Young-Nan Cho et al.
Ki-Jeong Park et al.
Introduction: Dendritic cells (DCs) are crucial in immune responses but their roles in trauma patients remain poorly understood. This study aimed to investigate the frequencies and functions of plasmacytoid DCs (pDCs) and...
Characterization of the Cellular Immune Response to Group B Streptococcal Vaginal Colonization [0.03%]
表皮葡萄球菌阴道定植诱导的细胞免疫反应特征研究
Brady L Spencer,Dustin T Nguyen,Stephanie M Marroquin et al.
Brady L Spencer et al.
Introduction: Group B Streptococcus (GBS) asymptomatic colonizes the female genital tract (FGT) but can contribute to adverse pregnancy outcomes including pre-term birth, chorioamnionitis, and neonatal infection. We previ...
Potential Role of Aerobic Exercise in Attenuating Diabetic Cardiomyopathy via Modulation of P2X4-Mediated NLRP3 Inflammasome Activation and Pyroptosis [0.03%]
有氧运动通过调节P2X4介导的NLRP3炎性小体活化及细胞焦亡在糖尿病心肌病发生发展中潜在作用及其机制研究
Zonghan Liu,Yangjun Yang,Luchen Song et al.
Zonghan Liu et al.
Diabetic cardiomyopathy (DCM) is a common diabetic complication associated with chronic low-grade inflammation. Exercise is an effective therapy for DCM, though its mechanisms remain unclear. Here, we demonstrate that exercise mitigates pyr...
Single-cell RNA Sequencing In Pediatric Sepsis: γδ T Cell Exhibits A Differentiation To γδT17 Subtype Along With Significantly Enhanced Cell Communication With Neutrophils [0.03%]
儿童感染性休克的单细胞RNA测序：γδT细胞向促炎性的γδT17亚型分化并显著增强与中性粒细胞相互作用
Wen-Jie Zhou,Ting Feng,Yue-Li Mu et al.
Wen-Jie Zhou et al.
Abnormal immune responses are common clinical features in septic patients. γδ T cells, as innate immune cells, play an important role in host defense, immune surveillance and homeostasis. However, the immune characteristics of γδ T cell...
The Role of Piezo-type Mechanosensitive Ion Channel Component 1 in Inflammatory Bowel Disease [0.03%]
Piezo型机械敏感离子通道组件1在炎症性肠病中的作用
Cong Zhang,Huixin He,Xiaoyu Li et al.
Cong Zhang et al.
Piezo-type mechanosensitive ion channel component 1 (Piezo1) is an evolutionarily conserved and multifunctional mechanosensitive ion channel protein that has emerged as a significant contributor to the pathogenesis of inflammatory bowel dis...
The Role of IRAK-M in Pulmonary Diseases: Mechanisms and Therapeutic Implications [0.03%]
IRAK-M在肺部疾病中的作用：机制和治疗意义
Liying Zhai,Chunhua Du,Qian Zhao et al.
Liying Zhai et al.
Respiratory system diseases, including infections, inflammation, fibrosis, cancer, and others, impose a substantial burden on human health worldwide. The respiratory tract is constantly exposed to external stimuli due to its connection with...
A review of Proteases and Antiproteases for Immune Regulation and Potential Therapeutic Application in Pulmonary Fibrosis [0.03%]
蛋白酶和抗蛋白酶在免疫调节及潜在治疗肺纤维化应用中的研究进展评述
Sara Waqas Ahmed,Debananda Gogoi,Luke Forde et al.
Sara Waqas Ahmed et al.
Interstitial lung diseases (ILDs), or diffuse parenchymal lung diseases, are general terms for a group of over 200 conditions that result from the destruction of cells neighbouring the alveoli, leading to extensive inflammation and fibrosis...
Impact of ATP Synthase Subunit β on TLR Signaling Pathway in Promoting Airway Remodeling and Heterogeneity of Small Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease [0.03%]
ATP合酶亚基β通过TLR信号通路促进慢性阻塞性肺疾病气道重构及小气道上皮异质性形成的影响作用
Yabo Zhang,Hanyu Hou,Wanwan Sui et al.
Yabo Zhang et al.
Chronic obstructive pulmonary disease (COPD) is characterized by airway remodeling and epithelial cell dysfunction, yet the underlying regulatory mechanisms remain incompletely understood. This study aimed to investigate the role of ATP syn...