Interleukin-6 limits host susceptibility to urinary tract infection by promoting urothelial expulsion of intracellular bacteria [0.03%]
白细胞介素-6通过促进尿路上皮细胞清除胞内细菌而限制宿主对泌尿系统感染的易感性
Sudipti Gupta,Shradha Rajak,Hanna Cortado et al.
Sudipti Gupta et al.
Introduction: Interleukin (IL)-6 has an important role in limiting urinary tract infection (UTI). Mice lacking IL-6 are more susceptible to uropathogenic Escherichia coli (UPEC), including increased formation of intracell...
Pharmacological STING Activation Enhances Autophagy-Mediated Clearance of Mycobacterium tuberculosis in Human Macrophages [0.03%]
药理学STING激活可增强人类巨噬细胞中Mycobacterium tuberculosis的自噬介导清除作用
Fei Niu,Ronghao Zhong,Feifei Pu et al.
Fei Niu et al.
Objective: The cGAS-STING pathway is a critical sensor in the innate immune response to intracellular pathogens, yet its therapeutic potential for augmenting macrophage-mediated control of Mycobacterium tuberculosis (Mtb)...
Inhibition of Pseudomonas aeruginosa biofilm formation by peptidyl-arginine deiminases 2 and 4 [0.03%]
脯氨酰胺R朱瓜酸酶2和4通过抑制铜绿假单胞菌生物被膜形成发挥抗菌作用
Rory Baird,Debananda Gogoi,Luke Forde et al.
Rory Baird et al.
Pseudomonas aeruginosa (P. aeruginosa) is a significant pathogen associated with chronic infections, particularly in immunocompromised individuals. Its ability to form biofilms, combined with antibiotic resistance, plays a critical role in ...
Macrophages in Ulcerative Colitis: Immunomodulatory Roles, Phenotypic Switching, and Therapeutic Targeting [0.03%]
溃疡性结肠炎中的巨噬细胞：免疫调节作用、表型转换和治疗靶向
Maojun Zhao,Shaochen Yu,Mengjie Zhang et al.
Maojun Zhao et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by dysregulated immune responses in the gut. Macrophages, as key innate immune cells in the intestinal mucosa, play a central role ...
Clodronate liposomes untangle the role of hemocytes in Apis mellifera response to temperature variation and microbial infection [0.03%]
氯膦酸盐脂质体解锁蜜蜂对温度变化和微生物感染免疫反应中血细胞的作用机制
Michael Oeth,Deepak Kumar,Michael Goblirsch et al.
Michael Oeth et al.
Introduction: Hemocytes are central to honey bee (Apis mellifera) immunity, but the roles of their subtypes under combined stressors are unclear. We tested the effects of temperature and bacterial challenge on hemocyte ab...
Prior exposure of airway epithelial cells to mycobacteria reduces subsequent Mycobacterium tuberculosis infection and resulting inflammation [0.03%]
分枝杆菌预先暴露可减少气道上皮细胞继发的结核分枝杆菌感染及炎症反应
Amy M Barclay,Dennis K Ninaber,Kimberley V Walburg et al.
Amy M Barclay et al.
Repeated exposures to Mycobacterium tuberculosis (Mtb) and related species may influence host responses, which in turn may affect vaccine efficacy and could even render the host less or more susceptible to progression to active tuberculosis...
Inhalation of N-chlorotaurine is an effective treatment of Aspergillus fumigatus pneumonia in mice [0.03%]
一氧化氮合酶吸入N-氯化牛磺酸可有效治疗小鼠烟曲霉肺炎
Cornelia Speth,Günter Rambach,Andrea Windisch et al.
Cornelia Speth et al.
Introduction: N-chlorotaurine (NCT), a long-lived oxidant of human granulocytes, can be used topically as anti-infective in different body regions. The aim of the present study was to demonstrate the efficacy and tolerabi...
Compartment-Specific NK Cell Phenotypes Reveal Distinct Maturation and Activation States in Inflammatory Arthritis [0.03%]
针对炎症性关节炎的不同腔室NK细胞表型揭示了不同的成熟和活化状态
Franca Sophie Deicher,Tarik Exner,Maren Claus et al.
Franca Sophie Deicher et al.
Introduction: Synovial natural killer (NK) cells contribute to inflammation in arthritis by secreting cytokines and modulating synovial fibroblast activation. The aim of this study was to describe systemic versus local inflammatory changes ...
Neutrophil Plasticity in Airway Disease: Balancing Damage and Repair [0.03%]
气道疾病的中性粒细胞可塑性：损伤与修复之间的平衡
Sabina M Janciauskiene,Joanna Chorostowska-Wynimko,Beata Olejnicka et al.
Sabina M Janciauskiene et al.
Background Neutrophils, previously viewed as short-lived microbial killers, are now recognized as highly adaptable regulators of innate immunity. Advances in transcriptomic, metabolic, and epigenetic profiling reveal their remarkable hetero...
Chloroquine enhances MAVS-mediated cytokine induction and alters mitochondrial morphology [0.03%]
氯喹增强MAVS介导的细胞因子诱导并改变线粒体形态
Yu-Ting Kao,Wei-Sheng Chen,Chi-Ting Shie et al.
Yu-Ting Kao et al.
Introduction: Chloroquine (CQ), a well-known antimalarial agent, has been proposed as a potential antiviral compound due to its ability to interfere with multiple cellular pathways critical for viral replication. Although...