CLIPB4 Is a Central Node in the Protease Network that Regulates Humoral Immunity in Anopheles gambiae Mosquitoes [0.03%]
剪切体4在调节按蚊体液免疫的蛋白酶网络中处于核心地位
Xiufeng Zhang,Shasha Zhang,Junyao Kuang et al.
Xiufeng Zhang et al.
Insect humoral immune responses are regulated in part by protease cascades, whose components circulate as zymogens in the hemolymph. In mosquitoes, these cascades consist of clip-domain serine proteases (cSPs) and/or their non-catalytic hom...
Mitochondrial Damage-Associated Molecular Patterns and Metabolism in the Regulation of Innate Immunity [0.03%]
线粒体损伤相关分子模式和代谢对固有免疫的调节作用
Yanmin Lyu,Tianyu Wang,Shuhong Huang et al.
Yanmin Lyu et al.
The innate immune system, as the host's first line of defense against intruders, plays a critical role in recognizing, identifying, and reacting to a wide range of microbial intruders. There is increasing evidence that mitochondrial stress ...
MicroRNA-9-1 Attenuates Influenza A Virus Replication via Targeting Tankyrase 1 [0.03%]
microRNA-9-1通过靶向Tankyrase 1抑制A型流感病毒复制
Gayan Bamunuarachchi,Kishore Vaddadi,Xiaoyun Yang et al.
Gayan Bamunuarachchi et al.
An unstable influenza genome leads to the virus resistance to antiviral drugs that target viral proteins. Thus, identification of host factors essential for virus replication may pave the way to develop novel antiviral therapies. In this st...
TGF-β1 Inhibition of ACE2 Mediated by miRNA Uncovers Novel Mechanism of SARS-CoV-2 Pathogenesis [0.03%]
miRNA介导的TGF-β1抑制ACE2揭示了SARS-CoV-2致病新机制
Ewelina D Hejenkowska,Nilay Mitash,Joshua E Donovan et al.
Ewelina D Hejenkowska et al.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for COVID-19, utilizes receptor binding domain (RBD) of spike glycoprotein to interact with angiotensin (Ang)-converting enzyme 2 (ACE2). Altering ACE2 levels may...
Pro-Inflammatory of PRDM1/SIRT2/NLRP3 Axis in Monosodium Urate-Induced Acute Gouty Arthritis [0.03%]
单钠尿酸盐诱导的急性痛风性关节炎中PRDM1/SIRT2/NLRP3轴促炎症的作用
Qingsong Zhao,Nan Xia,Jinmei Xu et al.
Qingsong Zhao et al.
PR domain-containing 1 with zinc finger domain (PRDM1) has been reported as a promoter of inflammation, which is a critical process involved in the pathogenesis of acute gouty arthritis. Herein, we sought to ascertain the function of PRDM1 ...
Published Erratum
Journal of innate immunity. 2023 May 15;15(1):516. DOI:10.1159/000530893 2023
Phenotypic Characterization of Acoustically Enriched Extracellular Vesicles from Pathogen-Activated Platelets [0.03%]
声学增强的病原激活血小板细胞外囊泡表型特征分析
Frida Palm,Axel Broman,Genevieve Marcoux et al.
Frida Palm et al.
Extracellular vesicles (EVs) are derived from the membrane of platelets and released into the circulation upon activation or injury. Analogous to the parent cell, platelet-derived EVs play an important role in hemostasis and immune response...
Regulation of Macrophage Cell Surface GAPDH Alters LL-37 Internalization and Downstream Effects in the Cell [0.03%]
调节巨噬细胞表面GAPDH改变LL-37内吞及其对细胞的下游影响
Asmita Dhiman,Sharmila Talukdar,Gaurav Kumar Chaubey et al.
Asmita Dhiman et al.
Mycobacterium tuberculosis (M.tb), the major causative agent of tuberculosis, has evolved mechanisms to evade host defenses and persist within host cells. Host-directed therapies against infected cells are emerging as an effective option. C...
Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction [0.03%]
髓系细胞形式肽受体2缺乏加剧脓毒症诱导的心功能障碍
Jianmin Chen,Shani Austin-Williams,Caroline Elizabeth O&#x;Riordan et al.
Jianmin Chen et al.
Using a global formyl peptide receptor (Fpr) 2 knockout mouse colony, we have reported the modulatory properties of this pro-resolving receptor in polymicrobial sepsis. Herein, we have used a humanized FPR2 (hFPR2) mouse colony, bearing an ...
TLR7 Activation in M-CSF-Dependent Monocyte-Derived Human Macrophages Potentiates Inflammatory Responses and Prompts Neutrophil Recruitment [0.03%]
TLR7活化在M-CSF依赖的单核细胞来源的人巨噬细胞中增强炎症反应并募集中性粒细胞
Miriam Simón-Fuentes,Cristina Herrero,Lucia Acero-Riaguas et al.
Miriam Simón-Fuentes et al.
Toll-like receptor 7 (TLR7) is an endosomal pathogen-associated molecular pattern (PAMP) receptor that senses single-stranded RNA (ssRNA) and whose engagement results in the production of type I IFN and pro-inflammatory cytokines upon viral...