Bone Marrow Mesenchymal Stem Cells Release miR-378a-5p-Carried Extracellular Vesicles to Alleviate Rheumatoid Arthritis [0.03%]
骨髓间充质干细胞释放含有miR-378a-5p的细胞外囊泡以缓解类风湿性关节炎
Yaqin Zhang,Ziying Jiao,Shanshan Wang
Yaqin Zhang
This study investigates whether bone marrow mesenchymal stem cell (BMSC)-derived extracellular vesicles (EVs) can affect rheumatoid arthritis (RA) by delivering microRNA (miR)-378a-5p to regulate the interferon regulatory factor 1/signal tr...
YTHDC1-Modified m6A Methylation of Hsa_circ_0102678 Promotes Keratinocyte Inflammation Induced by Cutibacterium acnes Biofilm through Regulating miR-146a/TRAF6 and IRAK1 Axis [0.03%]
YTHDC1介导的Hsa_circ_0102678 m6A甲基化通过调控miR-146a/TRAF6和IRAK1轴促进痤疮丙酸杆菌生物膜诱导的角质形成细胞炎症
Meng Zhou,Yuzhen Liu,Haoxiang Xu et al.
Meng Zhou et al.
Introduction: CircRNAs are closely related to many human diseases; however, their role in acne remains unclear. This study aimed to determine the role of hsa_circ_0102678 in regulating inflammation of acne. ...
N6-Methyladenosine (m6A) Modification in Natural Immune Cell-Mediated Inflammatory Diseases [0.03%]
免疫细胞介导的炎症疾病中的腺苷N6-甲基化修饰
Yan Teng,Jin Yi,Junnian Chen et al.
Yan Teng et al.
The post-transcriptional N6-methyladenosine (m6A) modification of RNA influences stability, transport, and translation with implications for various physiological and pathological processes. Immune cell development, differentiation, and act...
Ivan C Acosta,Francis Alonzo rd
Ivan C Acosta
Background: The innate immune system is the first line of defense against microbial pathogens and is essential for maintaining good health. If pathogens breach innate barriers, the likelihood of infection is significantly...
Mesenchymal Stromal Cells Facilitate Neutrophil-Trained Immunity by Reprogramming Hematopoietic Stem Cells [0.03%]
骨髓间充质基质细胞通过重编程造血干细胞促进中性粒细胞获得性免疫记忆形成
Julie Ng,Anna E Marneth,Alec Griffith et al.
Julie Ng et al.
Novel therapeutics are urgently needed to prevent opportunistic infections in immunocompromised individuals undergoing cancer treatments or other immune-suppressive therapies. Trained immunity is a promising strategy to reduce this burden o...
Emerging Roles of cGAS-STING Signaling in Mediating Ocular Inflammation [0.03%]
环鸟苷酸-腺苷酸合成酶（cGAS）-干扰素基因刺激物（STING）信号通路在介导眼部炎症中的新兴作用
Linbin Zhou,Bo Man Ho,Hoi Ying Emily Chan et al.
Linbin Zhou et al.
Cyclic GMP-AMP (cGAMP) synthase (cGAS), a sensor of cytosolic DNA, recognizes cytoplasmic nucleic acids to activate the innate immune responses via generation of the second messenger cGAMP and subsequent activation of the stimulator of inte...
Perilipin 1 Deficiency Prompts Lipolysis in Lipid Droplets and Aggravates the Pathogenesis of Persistent Immune Activation in Drosophila [0.03%]
perilipin1缺陷促进脂肪滴的脂解并加重果蝇持续性免疫活化的病理发展
Lei Wang,Jiaxin Lin,Kaiyan Yang et al.
Lei Wang et al.
Lipid droplets (LDs) are highly dynamic intracellular organelles, which are involved in lots of biological processes. However, the dynamic morphogenesis and functions of intracellular LDs during persistent innate immune responses remain obs...
Selected β-Glucans Act as Immune-Training Agents by Improving Anti-Mycobacterial Activity in Human Macrophages: A Pilot Study [0.03%]
一种免疫训练剂：酵母β-葡聚糖改善人巨噬细胞的抗分枝杆菌活性：一项初步研究
Clara Braian,Lovisa Karlsson,Jyotirmoy Das et al.
Clara Braian et al.
Epigenetic reprogramming of innate immune cells by β-glucan in a process called trained immunity leads to an enhanced host response to a secondary infection. β-Glucans are structural components of plants, algae, fungi, and bacteria and th...
Inhibition of Piezo1 Ameliorates Intestinal Inflammation and Limits the Activation of Group 3 Innate Lymphoid Cells in Experimental Colitis [0.03%]
Piezo1抑制可减轻实验性结肠炎中的肠道炎症并限制第3组先天淋巴样细胞的活化
Chang Liu,Yanan Xia,Shichen Fu et al.
Chang Liu et al.
Piezo1, the mechanosensory ion channel, has attracted increasing attention for its essential roles in various inflammatory responses and immune-related diseases. Although most of the key immune cells in inflammatory bowel disease (IBD) have...
C-Terminal PEGylation Improves SAAP-148 Peptide's Immunomodulatory Activities [0.03%]
C端PEG修饰可增强SAAP-148多肽的免疫调节活性
Miriam E van Gent,Bep Schonkeren-Ravensbergen,Asma Achkif et al.
Miriam E van Gent et al.
Synthetic antibacterial and anti-biofilm peptide (SAAP)-148 was developed to combat bacterial infections not effectively treatable with current antibiotics. SAAP-148 is highly effective against antimicrobial-resistant bacteria without induc...