C-X-C Motif Chemokine Ligand 1 Promotes Colitis by Modulating the Gut Microbiota [0.03%]
CXCL1通过调节肠道菌群促进结肠炎发生
Hang Zhao,Wenhua Li,Xin Zhou et al.
Hang Zhao et al.
Introduction: C-X-C motif chemokine ligand 1 (CXCL1) is a potent neutrophil chemoattractant that plays a pivotal role in recruiting neutrophils during inflammatory conditions. This study explored the role of CXCL1 in modu...
Development of a C3 Humanized Rat as a New Model for Evaluating Novel C3 Inhibitors [0.03%]
C3人源化大鼠的开发作为评估新型C3抑制剂的新模型
Jin Y Chen,Lingjun Zhang,Maojing Yang et al.
Jin Y Chen et al.
Introduction: C3 is central for all complement activation pathways, thus making it an attractive therapeutic target. Many C3-targeted agents are under extensive development with one already approved for clinical use. Howe...
Prabhakar Arumugam,Tammy Kielian
Prabhakar Arumugam
Background: Staphylococcus aureus (S. aureus) is a common cause of hospital- and community-acquired infections that can result in various clinical manifestations ranging from mild to severe disease. The bacterium utilizes...
Association of Vitamin D with Severity and Outcome of COVID-19: Clinical and Experimental Evidence [0.03%]
维生素D与COVID-19严重性和预后的关系：临床和实验证据
Georgios Renieris,Spyros Foutadakis,Theano Andriopoulou et al.
Georgios Renieris et al.
Introduction: The role of vitamin in COVID-19 remains controversial. We investigated the association between endogenous vitamin D and the severity of COVID-19 as well as the mechanisms of action of vitamin D supplementati...
Dylan Gerard Ryan,Christian Graham Peace,Alexander Hooftman
Dylan Gerard Ryan
Background: Innate immune cells play a crucial role in responding to microbial infections, but their improper activation can also drive inflammatory disease. For this reason, their activation state is governed by a multit...
Advanced Glycation End Products-Induced Activation of Keratinocytes: A Mechanism Underlying Cutaneous Immune Response in Psoriasis [0.03%]
AGEs诱导的角质形成细胞活化在银屑病皮肤免疫反应中的作用机制研究
Pan Kang,Jianru Chen,Shiyu Wang et al.
Pan Kang et al.
Psoriasis is a common inflammatory skin disease, in which epidermal keratinocytes play a vital role in its pathogenesis by acting both as the responder and as the accelerator to the cutaneous psoriatic immune response. Advanced glycation en...
Human Monocytes Exposed to SARS-CoV-2 Display Features of Innate Immune Memory Producing High Levels of CXCL10 upon Restimulation [0.03%]
暴露于SARS-CoV-2的人单核细胞表现出先天免疫记忆的特征，并在再次刺激时产生高水平的CXCL10
Jelena Cvetkovic,Ronald H J Jacobi,Alberto Miranda-Bedate et al.
Jelena Cvetkovic et al.
Introduction: A role for innate immune memory in protection during COVID-19 infection or vaccination has been recently reported. However, no study so far has shown whether the severe acute respiratory syndrome coronavirus...
Human Ribonuclease 6 Has a Protective Role during Experimental Urinary Tract Infection [0.03%]
人源性核糖核酸酶6在实验性尿路感染中的保护作用
Juan de Dios Ruiz-Rosado,Hanna Cortado,Macie Kercsmar et al.
Juan de Dios Ruiz-Rosado et al.
Mounting evidence suggests that antimicrobial peptides and proteins (AMPs) belonging to the RNase A superfamily have a critical role in defending the bladder and kidney from bacterial infection. RNase 6 has been identified as a potent, leuk...
Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody [0.03%]
一种新型补体C5a受体拮抗单克隆抗体的功能研究
Leon Cyranka,Ida Mariegaard,Mikkel-Ole Skjødt et al.
Leon Cyranka et al.
Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory ...
Immunothrombosis and Complement Activation Contribute to Disease Severity and Adverse Outcome in COVID-19 [0.03%]
免疫凝血和补体激活导致了COVID-19的疾病严重性和不良预后
Tiphaine Ruggeri,Yasmin De Wit,Noëlia Schärz et al.
Tiphaine Ruggeri et al.
Severe COVID-19 is characterized by systemic inflammation and multiple organ dysfunction syndrome (MODS). Arterial and venous thrombosis are involved in the pathogenesis of MODS and fatality in COVID-19. There is evidence that complement an...