Yimin Ding,Qian Cao,Wenjuan Yang et al.
Yimin Ding et al.
Background: Although substantial efforts have been made by researchers to develop drugs, a disappointing reality is that the emergence of drug resistance is an unavoidable reality for the majority of patients. In recent y...
Single-Nucleus Sequencing of Silkworm Larval Brain Reveals the Key Role of Lysozyme in the Antiviral Immune Response in Brain Hemocytes [0.03%]
家蚕幼虫脑单核测序揭示溶菌酶在家蚕抗病毒免疫反应中的关键作用
Min Feng,Shigang Fei,Jinglei Zou et al.
Min Feng et al.
Introduction: The brain is considered as an immune-privileged organ, yet innate immune reactions can occur in the central nervous system of vertebrates and invertebrates. Silkworm (Bombyx mori) is an economically importan...
Eosinophils Are an Endogenous Source of Interleukin-4 during Filarial Infections and Contribute to the Development of an Optimal T Helper 2 Response [0.03%]
嗜酸性粒细胞是丝虫感染期间内源性的白细胞介素-4来源 并有助于产生最优的T辅助2反应
Cécile Guth,Pia Philippa Schumacher,Archena Vijayakumar et al.
Cécile Guth et al.
Introduction: Interleukin-4 (IL-4) is a central regulator of type 2 immunity, crucial for the defense against multicellular parasites like helminths. This study focuses on its roles and cellular sources during Litomosoide...
Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host Cells [0.03%]
甘油醛-3-磷酸脱氢酶与刺突蛋白结合并抑制SARS-CoV-2进入宿主细胞
Rahul Dilawari,Gaurav Kumar Chaubey,Radheshyam Modanwal et al.
Rahul Dilawari et al.
Introduction: Coronavirus disease 2019 caused by coronavirus-2 (SARS-CoV-2) has emerged as an aggressive viral pandemic. Health care providers confront a challenging task for rapid development of effective strategies to c...
Immunometabolic Regulation of Bacterial Infection, Biofilms, and Antibiotic Susceptibility [0.03%]
细菌感染、生物膜和抗生素抗性中的免疫代谢调控
Ying-Tsun Chen,Gaurav Kumar Lohia,Samantha Chen et al.
Ying-Tsun Chen et al.
Background: Upon infection, mucosal tissues activate a brisk inflammatory response to clear the pathogen, i.e., resistance to disease. Resistance to disease is orchestrated by tissue-resident macrophages, which undergo pr...
TLR10: An Intriguing Toll-Like Receptor with Many Unanswered Questions [0.03%]
TLR10：一个有很多未解之谜的 Toll 样受体
Carolina Rego Rodrigues,Yadu Balachandran,Gurpreet Kaur Aulakh et al.
Carolina Rego Rodrigues et al.
Background: Toll-like receptors (TLRs) are one of the first pattern recognition receptors found in the innate immune system. The TLR family has 12 members (TLR1-TLR9, TLR11-TLR13) in mice and 10 members (TLR1-TLR10) in hu...
Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Inflammation and Pathogen-Associated Interactions [0.03%]
氧化低密度脂蛋白受体-1在炎症和病原体相关相互作用中的作用
Sarah Truthe,Tilman E Klassert,Stefan Schmelz et al.
Sarah Truthe et al.
Background: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is known as a major receptor for oxidized low-density lipoproteins (oxLDL) and plays a significant role in the genesis of atherosclerosis. Recent...
Na Rong,Xiaohui Wei,Jiangning Liu
Na Rong
Background: Neutrophils are the first line of defense against pathogens. They are divided into multiple subpopulations during development and kill pathogens through various mechanisms. Neutrophils are considered one of th...
Ehrlichia chaffeensis Co-Opts Phagocytic Hemocytes for Systemic Dissemination in the Lone Star Tick, Amblyomma americanum [0.03%]
埃里希氏菌夺取吞噬细胞以实现星形蓖麻子硬蜱中的系统性播散
Abdulsalam Adegoke,Julia Hanson,Ryan C Smith et al.
Abdulsalam Adegoke et al.
Introduction: Hematophagous arthropods can acquire and transmit several pathogens of medical importance. In ticks, the innate immune system is crucial in the outcome between vector-pathogen interaction and overall vector ...
Mechanisms and Therapeutic Strategies for MAFLD Targeting TLR4 Signaling Pathways [0.03%]
针对TLR4信号通路治疗MAFLD的机制和策略研究
Guanghui Ren,Changchuan Bai,Sitong Yi et al.
Guanghui Ren et al.
Background: Metabolic-associated fatty liver disease (MAFLD) is one of the most common chronic liver diseases. The underlying pathophysiological mechanisms are intricate and involve various factors. Unfortunately, there i...