Incubation with tau aggregates increases hippocampal circuit excitability and enhances long-term depression in acute mouse hippocampal slices [0.03%]
tau聚集体的孵育增加海马回路兴奋性并增强小鼠急性海马切片的长时程抑制作用
Alice Wang,Abbie Richardson,Isabelle Emmett et al.
Alice Wang et al.
Aggregation of the protein tau is a key pathological hallmark of tauopathies such as Alzheimer's Disease. Tau dissociates from microtubules and diffuses from the axon into the soma-dendritic compartment, where it aggregates firstly into oli...
Morphological evidence for neuronal connections between the olfactory neurogenic region and the striatum in adult rats [0.03%]
成年大鼠嗅觉神经发生区与纹状体相连接的形态学证据
Kamila Fabianová,Marcela Martončíková,Ivo Vanický et al.
Kamila Fabianová et al.
The regulatory mechanisms of postnatal neurogenesis in the subventricular zone (SVZ) and the rostral migratory stream (RMS) are still not fully understood. Recent evidence suggests that neurogenesis in the SVZ/RMS may be regulated by neuron...
Topographic correspondence between retinotopic and whisker somatosensory map in mouse higher visual area and its development [0.03%]
小鼠高级视觉区视野与触觉地图的地形对应关系及其发育过程
Hanaka Matsumoto,Tomonari Murakami,Kenichi Ohki
Hanaka Matsumoto
Aligning the topography maps of different sensory modalities in the brain is considered to be important for the unified perception of multiple sensory modalities. In mice, the superior colliculus receives both visual and whisker-related som...
Summary statistics of learning link changing neural representations to behavior [0.03%]
转换神经表示到行为的学习链接的摘要统计学数据
Jacob A Zavatone-Veth,Blake Bordelon,Cengiz Pehlevan
Jacob A Zavatone-Veth
How can we make sense of large-scale recordings of neural activity across learning? Theories of neural network learning with their origins in statistical physics offer a potential answer: for a given task, there are often a small set of sum...
Clustered architecture of ipsilateral and interhemispheric connections in macaque ventrolateral prefrontal cortex [0.03%]
猕猴外侧前额叶皮层同侧和跨半球连接的模块化架构
Danling Hu,Hangqi Li,Toru Takahata et al.
Danling Hu et al.
The fine-scale organization of intrinsic and extrinsic connections in the primate ventrolateral prefrontal cortex (VLPFC), a region essential for higher cognitive functions, remains poorly understood. This contrasts with, for example, the w...
Spike-timing-dependent plasticity offers delay-gated oscillatory potentiation for autaptic weights [0.03%]
基于脉冲时间依赖可塑性的自突触权重振荡增强的延迟门控机制
Risa Onda,Mihoko Ishida,Kouhei Hattori et al.
Risa Onda et al.
Neuronal networks in animal brains are considered to realize specific filter functions through the precise configuration of synaptic weights, which are autonomously regulated without external supervision. In this study, we employ a single H...
How perceptual learning rewires brain connectivity: lessons from the visual system in a top-down perspective [0.03%]
从顶层视角看感知学习如何重构脑连接性：视觉系统的启示
Alan Consorti,Alessandro Sale
Alan Consorti
Neural circuits sculpt their structure and modify the strength of their connections to effectively adapt to the external stimuli throughout life. In response to practice and experience, the brain learns to distinguish previously undetectabl...
Deviance detection and regularity sensitivity in dissociated neuronal cultures [0.03%]
离体神经元培养中的偏差检测与规律敏感性
Zhuo Zhang,Amit Yaron,Dai Akita et al.
Zhuo Zhang et al.
Introduction: Understanding how neural networks process complex patterns of information is crucial for advancing both neuroscience and artificial intelligence. To investigate fundamental principles of neural computation, ...
Zhaofan Liu,CongCong Du,KongFatt Wong-Lin et al.
Zhaofan Liu et al.
Bow-tie architecture (BTA) is widely observed in biological neural systems, yet the underlying mechanism driving its spontaneous emergence remains unclear. In this study, we identify a novel formation mechanism by training multi-layer neura...
Volitional and forced running ability in mice lacking intact primary motor cortex [0.03%]
完整初级运动皮层缺失小鼠的意志跑步和被迫跑步能力
Ryusei Abo,Mei Ishikawa,Rio Shinohara et al.
Ryusei Abo et al.
The coordination of various brain regions achieves both volitional and forced motor control, but the role of the primary motor cortex in proficient running motor control remains unclear. This study trained mice to run at high performance (>...