Cellular senescence in brain aging and neurodegeneration: from molecular mechanisms to translational opportunities [0.03%]
细胞衰老与脑老化及神经退行性病变：从分子机制到转化机遇
Yahveth Cantero-Fortiz,Christopher Butler,Xavier Montalbán et al.
Yahveth Cantero-Fortiz et al.
Aging remains the predominant risk factor for Alzheimer's disease (AD) and other neurodegenerative disorders, yet the mechanisms linking systemic aging to brain dysfunction remain incompletely understood. Cellular senescence, a state of sta...
Prefrontal long-range somatostatin inhibitory projections modulate fear expression [0.03%]
顶叶长程生长抑素抑制性投射体调制恐惧表达式
Maiena Aincy,Anass El Azraoui,Fabrice Chaudun et al.
Maiena Aincy et al.
Memory extends beyond the simple encoding of learned associations; it also requires the flexible and context-dependent expression of associative memories to appropriately guide behavior. Auditory fear conditioning provides a powerful model ...
Transcriptomic signatures of hippocampal active place avoidance memory maintenance [0.03%]
基于转录组测序的海马区主动位置回避记忆维持标志物的研究
Isaac Vingan,Shwetha Phatarpekar,Victoria Sook Keng Tung et al.
Isaac Vingan et al.
The gene expression changes associated with memory acquisition, consolidation and reconsolidation-all active epochs in memory formation-have been well characterized in the rodent hippocampus. Less is known, however, of the changes in gene e...
Early and transient increase in cortical pyramidal cell excitability and delayed alteration of evoked synaptic transmission and t-SNARE proteins content in the hippocampus and neocortex of neonatal and juvenile Stxbp1 heterozygous mice [0.03%]
Stxbp1杂合突变小鼠海马和皮层神经元的早期兴奋性增高及成熟后神经递质释放功能降低及合成运输相关蛋白表达减少
Louison Pineau,Mélanie Brosset-Heckel,Hélène Becq et al.
Louison Pineau et al.
De novo mutations in the Stxbp1 gene lead to Munc18.1 haploinsufficiency and are a major cause of neurodevelopmental disorders. Because Munc18.1 is essential for vesicular exocytosis, most electrophysiological investigations have focused on...
Remifentanil self-administration promotes circuit- and sex-specific adaptations within the prefrontal-accumbens pathways [0.03%]
瑞米芬太尼自身给药会在前额皮质-伏隔核环路中促进性别特异性的适应性变化
Saurabh S Kokane,Shalana I Atwell,Aric C Madayag et al.
Saurabh S Kokane et al.
Introduction: The nucleus accumbens (NAc) and its excitatory input from the medial prefrontal cortex (mPFC) form a critical circuit underlying drug-induced plasticity associated with addiction-related behaviors. However, ...
Microglial state transitions are constrained by developmental and metabolic checkpoints [0.03%]
微胶质细胞状态转换受发育和代谢检查点的限制
Adil El Mesaoudi,Dong Won Kim
Adil El Mesaoudi
Single-cell transcriptomic and epigenomic profiling has revealed extensive microglial heterogeneity across development, homeostasis, and disease. However, one recurring observation remains unexplained. Only subsets of microglia adopt expect...
Neurovascular unit remodeling: focusing on glial cells in stroke injury and recovery [0.03%]
神经血管单元重塑：中风损伤与恢复中的胶质细胞作用
Meng Gong,Xinyi Li,Qiang Yuan et al.
Meng Gong et al.
Stroke stands as a predominant global contributor to mortality and persistent disability, marked by a sequential cascade of pathophysiological perturbations. Moving beyond the traditional neuron-focused paradigm, contemporary stroke researc...
Perinatal mAChR-mediated activation of cortical subplate neurons elicits network activity driving basket cell differentiation [0.03%]
胆碱能活化皮质下板神经元诱导产生GABAergic篮细胞网络活动的作用机制研究
Petra Wahle,Michelle Kaczmarski,Christian Riedel et al.
Petra Wahle et al.
The activation of mAChR on subplate neurons has been shown to trigger oscillatory glutamatergic network activity in early postnatal neocortex. Here, we explored the long-term consequences of subplate activation on the differentiation of cor...
The bradykinin B2 receptor as a context-dependent modulator of neural circuit function [0.03%]
缓激肽B2受体作为神经环路功能的上下文依赖调节因子
Juliene L S Silva,Mariana R Tavares,Luana Lavezo et al.
Juliene L S Silva et al.
The kallikrein-kinin system (KKS) is a proteolytic signaling pathway traditionally associated with vascular regulation and inflammation, but increasing evidence indicates that its components are also expressed in the central nervous system....
Prenatal stress shapes discrete responses during early recovery from repeated adult stress [0.03%]
孕期应激影响重复成年期应激后的早期恢复反应
Branden G Verosky,Jessica L Anderson,Helen J Chen et al.
Branden G Verosky et al.
Introduction: Prenatal stress is associated with increased risk for psychiatric disorders in offspring, yet many exposed individuals do not develop psychopathology, suggesting prenatal stress may confer a latent vulnerabi...