Solomon E Gibson,Xiaofeng Tao,Guofu Shen et al.
Solomon E Gibson et al.
Introduction: Serotonin (5-HT) is a neurotransmitter that is involved in retinal development, physiology, and vision, yet the specific contribution of individual 5-HT receptors to retinal function is poorly characterized....
Delayed onset of striatal projection neuron hyperexcitability in Fmr1-/y mice [0.03%]
弗成氏鼠大脑纹状体投射神经元兴奋性增强的延迟发生
Lars Nelson,Michael Janeček,Michael Matarazzo et al.
Lars Nelson et al.
Introduction: Fragile X Syndrome (FXS), the most common genetic cause of intellectual disability and autism spectrum disorder (ASD), results from silencing of the FMR1 gene and consequent loss of Fragile X Messenger Ribon...
Aryl hydrocarbon receptor deficiency enhances astrocyte sensitivity to LPS-induced inflammation [0.03%]
芳香烃受体缺乏增强星形胶质细胞对LPS诱导的炎症的敏感性
Emmanuel Ojo,Shelley A Tischkau
Emmanuel Ojo
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor linked to the control of immunological responses. Although AhR has been investigated in relation to lipopolysaccharide (LPS) peripheral inflammation, its role in...
Aquaporin-4 in glioblastoma: a nexus of glymphatic dysfunction, edema, immune evasion, and treatment resistance [0.03%]
水通道蛋白-4与胶质母细胞瘤的关系：淋巴脑脊液循环障碍、水肿、免疫逃避和治疗抵抗的交汇点
Leandro Castañeyra-Ruiz,Ibrahim González-Marrero,Luis H García-Abad et al.
Leandro Castañeyra-Ruiz et al.
Glioblastoma (GBM) progression is linked to aquaporin-4 (AQP4), whose functions extend beyond water transport to influence perivascular architecture, immune modulation, edema, and treatment response. In the healthy brain, AQP4 is highly pol...
Tmprss3 is expressed in several cell types of the inner ear including type II but hardly in type I spiral ganglion neurons [0.03%]
Tmprss3在耳内多种细胞类型中表达，包括II型但很少在I型螺旋神经节神经元中表达
Ramil Arora,Lucie Pifková,André Ulrich Deutschmann et al.
Ramil Arora et al.
Mutations in the transmembrane serine protease 3 gene (TMPRSS3) cause non-syndromic hearing impairment, with congenital (DFNB10) or late childhood onset (DFNB8). In some reports, these patients were found to have lower speech comprehension ...
Ionic mechanisms underlying bistability in spinal motoneurons: insights from a computational model [0.03%]
脊髓运动神经元双稳态的离子机制：来自计算模型的见解
Yaroslav I Molkov,Florent Krust,Russell Jeter et al.
Yaroslav I Molkov et al.
Spinal motoneurons are the final output of spinal circuits that engage skeletal muscles to generate motor behaviors. Many motoneurons exhibit bistable behavior, alternating between a quiescent resting state and a self-sustained firing mode,...
Microglia-orchestrated neuroinflammation and synaptic remodeling: roles of pro-inflammatory cytokines and receptors in neurodegeneration [0.03%]
小胶质细胞调控的神经炎症和突触重塑：促炎细胞因子及其受体在神经退行性疾病中的作用
Guang Yang,Xiao Xu,Waimao Gao et al.
Guang Yang et al.
Microglia, the innate immune cells of the central nervous system (CNS), play essential roles in maintaining neural homeostasis through dynamic interactions with neurons and other brain structures. While their protective functions are well-e...
Editorial: New approaches to overcome the blood-brain barrier for the treatment of CNS disorders [0.03%]
论著：用于治疗中枢神经系统疾病的超轴突屏障的新方法
Mikko Gynther,Gert Fricker,Sabrina Petralla
Mikko Gynther
The role of the vesicular monoamine transporter 2 in the inhibitory effect of tetrabenazine and valbenazine compared to reserpine on the vesicular release of monoamine transmitters [0.03%]
与利舍平相比左旋多巴胺转运蛋白2在四苯扎oline和缬氨酚对单胺神经递质囊泡释放抑制作用中的作用研究
Fruzsina Maácz,Erika Gyöngyi Bán,Attila Brassai et al.
Fruzsina Maácz et al.
Background: Vesicular monoamine transporter 2 (VMAT-2) plays a vital role in packaging cytosolic monoamine transmitters into axon terminal vesicles, which can be released in response to action potentials. Reserpine (RSP),...
Intrinsic and synaptic regulation of axonal excitability in dopaminergic neurons [0.03%]
多巴胺能神经元轴突兴奋性的内在和突触调节机制研究
Jackie Seddon,Paul F Kramer
Jackie Seddon
Dopamine released from the axon terminals of dopaminergic neurons is central to behaviors like reward learning and complex motor output. The dynamic control of dopamine release canonically occurs through two main mechanisms: the modulation ...