Single-nucleus transcriptomics identifies cell cycle and synaptic pathway dysregulation during OPC-to-glioma progression [0.03%]
单核转录组学识别少突胶质前体细胞向胶质瘤进展过程中的细胞周期和突触通路异常
Dennis Huang,Angeliki Mela,Hye-Jin Park et al.
Dennis Huang et al.
Gliomas are characterized by poor survival rate and limited options for treatment. Based on the transcriptional enrichment for oligodendrocyte progenitor cell (OPC) transcripts, the proneural glioma is thought to arise from transformation o...
Gut-brain axis mechanisms of remote brain dysfunction after traumatic spinal cord injury: immune inflammation, the vagus nerve, and neuroendocrine pathways [0.03%]
脊髓损伤后的肠道菌群远程脑功能障碍机制：免疫炎症、迷走神经和神经内分泌途径
Yutong Liu,Haifeng Zhang,Bingkai Ren
Yutong Liu
Traumatic spinal cord injury (SCI) has traditionally been regarded as a central nervous system injury mainly confined to the injured segment. However, increasing evidence indicates that SCI can also induce neuroinflammation, cognitive decli...
Editorial: Emerging mechanisms in neuroinflammation: potential therapeutic targets for neurodegenerative diseases [0.03%]
述评·神经炎症的新机制及其作为神经退行性疾病治疗靶标的潜力
Junhui Wang,Hongxing Wang,Dirk M Hermann
Junhui Wang
Case Report: A case of paraneoplastic autoimmune encephalitis with concurrent anti-GABABR and anti-SOX1 antibody positivity [0.03%]
个例报告：同时检测出抗GABABR和抗SOX1阳性的小细胞肺癌相关自身免疫性脑炎病例报告
Feng Liu,Ye-Han Jiang,Yu-Fang Hu et al.
Feng Liu et al.
Background: Paraneoplastic autoimmune encephalitis (PAE) is most commonly associated with small cell lung cancer (SCLC). Anti-γ-aminobutyric acid B receptor (GABABR) antibodies underlie a treatable limbic syndrome, where...
Editorial: Cell therapy in the central nervous system and its crosstalk with the immune system [0.03%]
脑科学：细胞治疗及其与免疫系统的相互作用
María Norte-Munoz,Raquel Boia,David García-Bernal et al.
María Norte-Munoz et al.
Ethanol selectively disrupts neuronal microexon regulation and chromatin marks in PC12 cells [0.03%]
乙醇选择性地破坏微外显子在PC12细胞中的神经元调控和染色质印记
Montserrat Olivares-Costa,Pascal Jorratt,Camila Morales et al.
Montserrat Olivares-Costa et al.
Introduction: Exposure to alcohol (ethanol) is the most common toxic insult during human development and is a teratogenic agent associated with abnormalities ranging from behavioral disorders to fetal alcohol syndrome. Et...
Up regulated hippocampal insulin pathway and oxidative stress are related to opposite changes in olfaction and episodic memory in a compensatory metabolic syndrome model in rats [0.03%]
大鼠代偿性代谢综合征模型中海马胰岛素信号通路上调及氧化应激与嗅觉和情景记忆的相反改变有关
Pedro Isauro Clavel-Pérez,Bryan V Phillips-Farfán,Luz Camacho-Castillo et al.
Pedro Isauro Clavel-Pérez et al.
Insulin resistance, a major component of metabolic syndrome (MetS), is involved in phosphorylated tau and beta amyloid buildup, linking MetS to neurodegenerative processes, e.g., Alzheimer's disease. One of the initial signs of neurodegener...
Blood-brain barrier integrity disruption linked to brain lesions and relapse prediction in Southern Chinese anti-NMDAR encephalitis patients [0.03%]
南方中国抗N-甲基-D天冬氨酸受体脑炎患者血脑屏障完整性破坏与脑病变和复发预测有关联
Lingling Tong,Hui Chen,Yanzhen Huang et al.
Lingling Tong et al.
Objective: This study aims to investigate the characteristic brain abnormalities in Southern Chinese patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and to explore their association with blood-brain ...
Siglec-1 upregulation and macrophage activation in age-related hearing loss: insights from integrated transcriptomic studies in mice and humans [0.03%]
整合转录组研究揭示小鼠和人类衰老相关听力损失中的Siglec-1上调和巨噬细胞活化现象
Di Ji,Qian Li,Baiyang Ren et al.
Di Ji et al.
Macrophage activation is closely associated with age-related hearing loss (ARHL), and Siglec-1 may be involved in modulating macrophage activation. This study aimed to investigate the immunological mechanisms underlying spiral ganglion neur...
Pharmacological activation of cGMP signaling promotes astrocyte remodeling and enrichment of perivascular GLUT1 in the murine retina [0.03%]
药理学激活cGMP信号促进小鼠视网膜星形胶质细胞重塑和血管周围GLUT1富集
Kristin L Clark,Shane Mecca,Elio Almaoui et al.
Kristin L Clark et al.
Astrocytes regulate metabolic exchange between the vasculature and neurons in the central nervous system (CNS). In the retina of the eye, also a component of the CNS, astrocyte endfeet couple to vascular elements to mediate glucose uptake v...