Neural stem cell-derived extracellular vesicles drive early neuroprotective and anti-apoptotic responses in spinal cord injury organotypic slices [0.03%]
神经干细胞源性细胞外囊泡在脊髓损伤器官切片中的早期神经保护和抗凋亡作用
Kristyna Sintakova,Vojtech Sprincl,Ivan Arzhanov et al.
Kristyna Sintakova et al.
Introduction: Spinal cord injury (SCI) is a devastating neurological condition with limited regenerative capacity. Stem cell-based approaches have emerged as promising strategies due to their neuroprotective and immunomod...
Early life shifts in cortical inhibitory-excitatory balance underlies sensitive periods and skill development [0.03%]
早期皮质抑制性-兴奋性平衡的转变决定了敏感期和技能发展
Dekel Taliaz
Dekel Taliaz
Early human development is characterized by sensitive periods which impact long-term cognitive and behavioral outcomes. While these windows of heightened plasticity are well documented, the cellular mechanisms that enable and regulate them ...
Janet L Paluh,Debayan Das,Amitava Mukherjee
Janet L Paluh
Modulation of corneal sensory processing and pain responses by dry eye and corneal wounding [0.03%]
干眼和角膜损伤对角膜感觉加工及疼痛反应的调节作用
Ebru Yaman,Yangluowa Qu,Kaylin C Arpaia et al.
Ebru Yaman et al.
Background: Dry eye disease (DED) is a multifactorial disorder of the ocular surface in which tear film instability, epithelial barrier disruption, and neurosensory dysfunction contribute to symptom generation. Although s...
Neuregulin-1 promotes early regenerative and autophagic responses after ischemic stroke via spatial proteomics [0.03%]
神经生长因子通过空间蛋白质组学促进缺血性脑卒中的早期修复和自噬反应
Jessica M Noll,Christopher McGinley,Catherine J Augello et al.
Jessica M Noll et al.
Ischemic stroke remains a leading cause of death and long-term disability, yet effective treatments that promote recovery beyond the acute phase are lacking. Neuregulin-1 (NRG-1) has shown potent neuroprotective and anti-inflammatory proper...
Acute hyperexcitability differentially affects hippocampal neurogenesis features and spatial memory [0.03%]
急性高兴奋性对海马神经发生特征和空间记忆有不同影响
Diana López-Ibarra,Andrea Aguilar-Arredondo,Verónica Gaytan-Zeron et al.
Diana López-Ibarra et al.
Introduction: Epileptic seizures induce aberrant adult hippocampal neurogenesis (AHN), yet how varying seizure intensities affect this process and associated memory functions remains unclear. ...
Intensive multidisciplinary rehabilitation modulates serum α-synuclein and miRNA expression in Parkinson's disease: preliminary results of a randomized study [0.03%]
强化多学科康复可调节帕金森病患者血清α-突触核蛋白和miRNA表达：随机对照试验初步结果
Simone Agostini,Mario Meloni,Roberta Mancuso et al.
Simone Agostini et al.
Introduction: Parkinson's disease is a progressive neurodegenerative condition, and unfortunately, there are currently no treatments available that can halt or slow down its progression. However, recent research on intens...
Copper and cuproptosis-related genes as indictors for the diagnosis of injury time in traumatic brain injury: human cases and animal experiment [0.03%]
铜和与铜死亡相关基因在创伤性脑损伤伤后时间诊断中的指示作用：人类病例和动物实验研究
Rui Gu,Xiaojin Yu,Yaqing Tan et al.
Rui Gu et al.
Traumatic brain injury (TBI) is one of the most frequently encountered injuries in forensic practice. Nevertheless, a major technical bottleneck persists: there are no stable, specific indicators available for estimating the injury time of ...
Cerebrospinal fluid lipid profiles as exploratory biomarkers for pediatric meningitis: a proof-of-concept case series [0.03%]
脑脊液脂质谱作为儿科脑膜炎探索性生物标志物的概念验证病例系列研究
Feng Tang,Changzhen Li,Ye Zeng et al.
Feng Tang et al.
Objectives: To investigate the cerebrospinal fluid (CSF) lipid metabolite profiles of pediatric patients with purulent meningitis (PM) or viral meningitis (VM) and to explore their differential diagnostic potential. ...
Regulation of NMDA receptor interactions with the actin cytoskeleton in dendritic spine development [0.03%]
NMDAR与细胞骨架的相互作用在树突棘发育中的功能研究
Jarrett Lloyd,Karen Litwa
Jarrett Lloyd
In the central nervous system, the majority of excitatory synapses exist on small actin-enriched structures protruding from dendrites, known as dendritic spines. Actin cytoskeletal rearrangements drive dynamic changes in spine shape, size, ...