Up regulated hippocampal insulin pathway and oxidative stress are related to opposite changes in olfaction and episodic memory in a compensatory metabolic syndrome model in rats [0.03%]
大鼠代偿性代谢综合征模型中海马胰岛素信号通路上调及氧化应激与嗅觉和情景记忆的相反改变有关
Pedro Isauro Clavel-Pérez,Bryan V Phillips-Farfán,Luz Camacho-Castillo et al.
Pedro Isauro Clavel-Pérez et al.
Insulin resistance, a major component of metabolic syndrome (MetS), is involved in phosphorylated tau and beta amyloid buildup, linking MetS to neurodegenerative processes, e.g., Alzheimer's disease. One of the initial signs of neurodegener...
Blood-brain barrier integrity disruption linked to brain lesions and relapse prediction in Southern Chinese anti-NMDAR encephalitis patients [0.03%]
南方中国抗N-甲基-D天冬氨酸受体脑炎患者血脑屏障完整性破坏与脑病变和复发预测有关联
Lingling Tong,Hui Chen,Yanzhen Huang et al.
Lingling Tong et al.
Objective: This study aims to investigate the characteristic brain abnormalities in Southern Chinese patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis and to explore their association with blood-brain ...
Siglec-1 upregulation and macrophage activation in age-related hearing loss: insights from integrated transcriptomic studies in mice and humans [0.03%]
整合转录组研究揭示小鼠和人类衰老相关听力损失中的Siglec-1上调和巨噬细胞活化现象
Di Ji,Qian Li,Baiyang Ren et al.
Di Ji et al.
Macrophage activation is closely associated with age-related hearing loss (ARHL), and Siglec-1 may be involved in modulating macrophage activation. This study aimed to investigate the immunological mechanisms underlying spiral ganglion neur...
Pharmacological activation of cGMP signaling promotes astrocyte remodeling and enrichment of perivascular GLUT1 in the murine retina [0.03%]
药理学激活cGMP信号促进小鼠视网膜星形胶质细胞重塑和血管周围GLUT1富集
Kristin L Clark,Shane Mecca,Elio Almaoui et al.
Kristin L Clark et al.
Astrocytes regulate metabolic exchange between the vasculature and neurons in the central nervous system (CNS). In the retina of the eye, also a component of the CNS, astrocyte endfeet couple to vascular elements to mediate glucose uptake v...
Mice lacking two alleles of the schizophrenia risk gene Tcf4 and Olig2 display deficits in anxiety-related behavior, sensorimotor gating, and cognition [0.03%]
Tcf4基因的两种等位基因缺失的小鼠和Olig2表现出与焦虑相关的行为缺陷，感觉运动门控缺陷和认知障碍
Man-Hsin Chang,Ruofan Li,Marius Stephan et al.
Man-Hsin Chang et al.
Introduction: Oligodendrocytes (OLs) and myelination contribute to higher-order cognitive functions, and are impaired in several mental disorders, including schizophrenia (SZ). The SZ risk gene transcription factor 4 (TCF...
Astrocytes in systemic regulation of blood glucose and the development of type 2 diabetes [0.03%]
星形胶质细胞在全身性血糖调节及2型糖尿病发病机制中的作用
Zhen Wen,Peng Bai,Li Du et al.
Zhen Wen et al.
The central nervous system (CNS) relies primarily on glucose for energy, and therefore maintaining peripheral glucose homeostasis is essential to ensure adequate CNS energy supply and normal physiological functions. Historically, hypothalam...
TGFβ signalling maintains Sox4+ astrocyte progenitors and restricts the early differentiation of BLBP+ astrocytes in the mouse dentate gyrus [0.03%]
TGFβ信号传导维持Sox4+星形胶质细胞前体并限制小鼠齿状回BLBP+星形胶质细胞的早期分化
Kyoji Ohyama,Shoichiro Omura,Natsumi Takayama et al.
Kyoji Ohyama et al.
Astrocytes in the mouse hippocampal dentate gyrus (DG) derive, at least in part, from BLBP+ cells, but the mechanism that controls the onset of their differentiation remains poorly understood. To address this, we first characterised the dev...
Editorial: Synaptic plasticity across the lifespan: mechanisms, adaptation, and vulnerability [0.03%]
editorials | 终身突触可塑性：机制、适应及脆弱性
Sandra Guidi,Yanis Inglebert,Beatrice Uguagliati
Sandra Guidi
Editorial: The role of glia in ataxia and other neurodegenerative disorders [0.03%]
编者按：胶质细胞在共济失调和其他神经退行性疾病中的作用
Milica Cerovic,Rosella Abeti
Milica Cerovic
Stem cell therapy for stroke: mechanisms, clinical translation, and future perspectives [0.03%]
卒中干细胞治疗：机制、临床转化及未来展望
Yu Xia,Juan Jin,Lei Song et al.
Yu Xia et al.
Stroke remains a primary global driver of death and disability. Although acute revascularization therapies (intravenous thrombolysis and mechanical thrombectomy) have advanced, their narrow therapeutic windows result in persistent neurologi...