Immunity in SARS-CoV-2 Infection: Clarity or Mystery? A Broader Perspective in the Third Year of a Worldwide Pandemic [0.03%]
SARS-CoV-2感染的免疫反应：明朗还是谜团？全球大流行的第三年更广泛的视角
Katarzyna Kapten,Krzysztof Orczyk,Elzbieta Smolewska
Katarzyna Kapten
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its mechanisms have been thoroughly studied by researchers all over the world with the hope of finding answers that may aid the discovery of new treatment options or effective...
A Comprehensive Study on the Anti-cancer Effects of Quercetin and Its Epigenetic Modifications in Arresting Progression of Colon Cancer Cell Proliferation [0.03%]
槲皮素及其表观遗传修饰在抑制结肠癌细胞增殖方面的抗癌症效果的全面研究
Meenu Bhatiya,Surajit Pathak,Ganesan Jothimani et al.
Meenu Bhatiya et al.
Colon cancer etiology involves a wide spectrum of genetic and epigenetic alterations, finding it challenging to find effective therapeutic strategies. Quercetin exhibits potent anti-proliferative/apoptotic properties. In the present study, ...
Heterogeneity of Extracellular Vesicles and Particles: Molecular Voxels in the Blood Borne "Hologram" of Organ Function, Disfunction and Cancer [0.03%]
细胞外囊泡和颗粒的异质性：器官功能、失能和癌症的血源“全息图”中的分子体素
Janusz Rak,Leon Strzadala
Janusz Rak
Extracellular vesicles (EVs) and particles (EPs) serve as unique carriers of complex molecular information with increasingly recognized roles in health and disease. Individual EVs/EPs collectively contribute to the molecular fingerprint of ...
Ly-6A-Induced Growth Inhibition and Cell Death in a Transformed CD4+ T Cell Line: Role of Tumor Necrosis Factor-α [0.03%]
Ly-6A诱导的转化CD4+ T细胞系增殖抑制和细胞死亡：肿瘤坏死因子-α的作用
Akshay G Patel,Sarah Moxham,Anil K Bamezai
Akshay G Patel
Ly-6A, a member of the Ly-6/uPAR supergene family of proteins, is a cell adhesion and cell signaling protein. Signaling through Ly-6A activates the cell-intrinsic apoptotic cell death pathway in CD4+ T cell lines, as indicated by the releas...
Stress-Sensitive Regulators of Fetal Neurodevelopment in HIV and Preeclampsia: An Immunocytochemical Appraisal of Placental OGT and T4 Levels [0.03%]
HIV和子痫前期胎儿神经发育的应激敏感调节因子：胎盘OGT和T4水平的免疫细胞化学评价
Philemon D Shallie,Thajasvarie Naicker,Nihar R Nayak
Philemon D Shallie
Preeclampsia and HIV are a significant burden to maternal health globally, especially in low-middle income countries such as South Africa. In the KwaZulu-Natal province, SA antenatal HIV prevalence is 41.1%, while PE is 12%. PE and HIV infe...
An Assessment of the Serum Activity of ADH and ALDH in Patients with Primary Biliary Cholangitis [0.03%]
原发胆汁性胆管炎患者血清ADH和ALDH活性的评估
Blanka Wolszczak-Biedrzycka,Anna Bieńkowska,Elżbieta Zasimowicz et al.
Blanka Wolszczak-Biedrzycka et al.
Primary biliary cholangitis (PBC; previously known as primary biliary cirrhosis) is a chronic inflammation-induced cholestatic process in the liver. Antimitochondrial antibodies (AMAs) are observed in around 90% of patients, which suggests ...
Impact of Betamethasone Pretreatment on Engrafment of Cord Blood-Derived Hematopoietic Stem Cells [0.03%]
倍他米松预处理对脐血造血干细胞植入的影响
David Perna-Barrull,Laia Gomez-Muñoz,Silvia Rodriguez-Fernandez et al.
David Perna-Barrull et al.
Hematopoietic stem cell (HSC) transplantation is crucial to cure hematologic malignancies. Umbilical cord blood (UCB) is a source of stem cells, but 90% of UCB units are discarded due to low cellularity. Improving the engraftment capacities...
Agata Kozioł,Małgorzata Pupek
Agata Kozioł
Metabolomics is a new field of science dealing with the study and analysis of metabolites formed in living cells. The biological fluids used in this test method are: blood, blood plasma, serum, cerebrospinal fluid, saliva and urine. The mos...
Small Extracellular Vesicles Loaded with Immunosuppressive miRNAs Leads to an Inhibition of Dendritic Cell Maturation [0.03%]
装载免疫抑制性miRNA的微小细胞外囊泡诱导树突状细胞分化成熟抑制
Liliana Czernek,Łukasz Pęczek,Markus Düchler
Liliana Czernek
In particular conditions, inhibition of an immune response is required to prevent tissue damage. Among these conditions are diseases caused by an over-reactive immune response, such as autoimmune or allergic disorders, or imminent organ rej...
Jan Kowalski,Maciej Nowak,Bartłomiej Górski et al.
Jan Kowalski et al.
Recent decades have shed a new light on the pathomechanism of periodontal inflammation. While classic periodontology concentrates on biofilm control, oral hygiene improvement, professional tooth cleaning and surgical correction of damaged p...