Liraglutide Attenuates Endothelial Dysfunction by Inhibiting Hyperglycemia-Induced Endothelial Cell Senescence Through the LARP7/SIRT1 Pathway [0.03%]
利拉鲁肽通过LARP7/SIRT1途径抑制高血糖诱导的内皮细胞衰老来缓解内皮功能障碍
Weili Zhong,Ying Yang,Yanru Wang
Weili Zhong
Vascular endothelial cells (ECs) are pivotal in maintaining vascular homeostasis. Liraglutide (LIR) can prevent and reverse hyperglycemia-induced cell dysfunction. However, the mechanism by which it improves hyperglycemia-induced EC senesce...
Methylparaben Modulates the Relationship Between Autophagy and Apoptosis in Head and Neck Squamous Cell Carcinoma Lines [0.03%]
对羟基苯甲酸甲酯调节头颈鳞状细胞癌系中自噬和凋亡的关系
Ewa Jablonska,Agnieszka Iwaniuk,Wioletta Ratajczak-Wrona et al.
Ewa Jablonska et al.
In light of the increasing incidence of head and neck cancer and the widespread occurrence of methylparabens (MeP) in the human environment, which mimic the action of endogenous estrogens, we investigated the effect of this compound on head...
SCARA5 Induces Ferroptosis to Inhibit the Proliferation and Migration of Skin Melanoma Cells and Regulates the GPX4/ACSL4 Signaling Pathway [0.03%]
SCARA5通过诱导铁死亡抑制皮肤黑色素瘤细胞的增殖和迁移并调控GPX4/ACSL4信号通路
Tianyin Zheng,Xinyang Liu
Tianyin Zheng
Skin cutaneous melanoma (SKCM) is a highly aggressive skin cancer with poor prognosis in advanced stages, despite recent advances in immunotherapy and targeted treatments. Novel therapeutic targets are urgently needed to improve the patient...
CLEC5A Knockdown Reduces Oxidative Stress and Inflammation Caused by Lipopolysaccharide in Renal Tubular Epithelial Cells via the NF-κB/NLRP3 Signaling Pathway [0.03%]
CLEC5A敲低通过NF-κB/NLRP3信号途径降低脂多糖所致肾小管上皮细胞氧化应激和炎症反应
Zunjiang Chen,Chengfeng Pan,Xuexiu Chen et al.
Zunjiang Chen et al.
Sepsis-related acute kidney injury (S-AKI) is a severe condition characterized by rapid onset and high mortality. Thus, identifying effective treatments for S-AKI is of critical importance. Lipopolysaccharide (LPS) was used to activate HK-2...
Significance of the LL-37 Peptide Delivered from Human Cathelicidin in the Pathogenesis, Treatment, and Diagnosis of Sepsis [0.03%]
人源性阳离子抗菌肽LL-37在脓毒症发病机制、治疗和诊断中的意义
Angelika Mańkowska,Paulina Paprocka,Grzegorz Król et al.
Angelika Mańkowska et al.
Antimicrobial peptides, which function as the first line of host immune defense, have recently been identified as important immunomodulators of inflammation, and are involved as regulatory molecules in infections, including sepsis. Treatmen...
From Fleas to T Lymphocytes and Beyond: How did I Become an Immunologist, and What Has Resulted from It? [0.03%]
从跳蚤到T淋巴细胞及以后：我是如何成为免疫学家的，以及由此带来的成果？
Paweł Kisielow
Paweł Kisielow
A narrative from a co-author of studies explaining the cellular mechanisms of self/nonself discrimination by the immune system, set against the backdrop of significant advancements in immunology during the last quarter of the 20th century. ...
Overexpression of Annexin A1 Inhibits Pyroptosis and Improves Dry Eye Signs by Regulating the TRIM72/Nrf2/HO-1 Signaling Pathway [0.03%]
annexin a1过表达通过调节TRIM72/nrf2/ho-1信号通路抑制pyroptosis并改善干眼症状
Li Zhang,Peng Chen,Pengfei Han et al.
Li Zhang et al.
This study aimed to investigate the therapeutic potential of annexin A1 (ANXA1) overexpression in improving the signs of dry eye disease (DED) and to elucidate the underlying molecular mechanism. A murine model of DED was established by top...
Knockdown of MBD2 Attenuates LPS-Stimulated Inflammation and Apoptosis in WI-38 Cells Through the STAT-3 Pathway [0.03%]
MBD2基因干扰抑制LPS诱导的WI-38细胞炎症反应和凋亡的作用及机制研究
Yao Chen,Liqun Lu
Yao Chen
This study aims to investigate the role of MBD protein 2 (MBD2) in the pneumonia cell model of lipopolysaccharide (LPS)-stimulated WI-38 cells and to uncover the mechanism. LPS-stimulated WI-38 cells were constructed as an in vitro pneumoni...
Impact of Intraoperative Cell Salvage on Circulating Tumor Cells and Cellular Activity in Patients with Hepatocellular Carcinoma Undergoing Curative Resection: A Prospective Comparative Study [0.03%]
自体血回输对肝细胞癌根治性手术患者循环肿瘤细胞及血液有核细胞活性影响的前瞻性研究
Ke Yue,Lai-Wei You,Bao-Ji Hu et al.
Ke Yue et al.
This study investigates the effects of intraoperative cell salvage (IOCS) on cell survival rates, apoptosis levels, and circulating tumor cell (CTC) counts in patients with hepatocellular carcinoma (HCC) undergoing curative resection. A com...