Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products [0.03%]
天然产物对肿瘤微环境中药物抑制细胞的调控作用
Jhon Jairo Calderon,Karol Prieto,Paola Lasso et al.
Jhon Jairo Calderon et al.
During carcinogenesis, the microenvironment plays a fundamental role in tumor progression and resistance. This tumor microenvironment (TME) is characterized by being highly immunosuppressive in most cases, which makes it an important target...
Antioxidant and Anti-inflammatory Effects of α-Lipoic Acid on Lipopolysaccharide-induced Oxidative Stress in Rat Kidney [0.03%]
α-硫辛酸对脂多糖诱导的大鼠肾氧化应激的抗氧化和抗炎作用
Beata Skibska,Ewa Kochan,Andrzej Stanczak et al.
Beata Skibska et al.
α-Lipoic acid (α-LA) is a naturally occurring organosulfur component. Oxidative stress plays an essential role in the pathogenesis of various diseases, such as kidney and cardiovascular diseases, diabetes, neurodegenerative disorders, can...
Are Measles-Mumps-Rubella (MMR) Antibodies Friends or Foes for Covid-19 Disease? [0.03%]
麻疹腮腺炎风疹(MMR)抗体是新冠病毒的朋友还是敌人？
Azza Salamony,Yara Shamikh,Khaled Amer et al.
Azza Salamony et al.
Many factors have been implicated in the pathogenesis and severity of COVID-19 pandemic. A wide variation in the susceptibility for SARS-CoV-2 infection among different population, gender and age has been observed. Multiple studies investig...
The Pyroptotic and Nonpyroptotic Roles of Gasdermins in Modulating Cancer Progression and Their Perspectives on Cancer Therapeutics [0.03%]
Gasdermin介导的细胞焦亡在肿瘤发生发展中的双重作用及展望
Sheng-Kai Hsu,Yi-En Chen,En-De Shu et al.
Sheng-Kai Hsu et al.
Gasdermins (GSDMs) are a protein family encoded by six paralogous genes in humans, including GSDMA, GSDMB, GSDMC, GSDMD, GSDME (also known as DFNA5), and DFNB59 (also known as pejvakin). Structurally, members of the GSDM family possess a C-...
Investigation of the Immunogenic Properties of Ovalbumin Modified by Urban Airborne Particulate Matter [0.03%]
urban air particulate matter改性的卵清蛋白的免疫原性研究
Bernadeta Nowak,Anna Wądołek,Olga Mazuryk et al.
Bernadeta Nowak et al.
Exposure to air particulate matter (PM) is linked to the blood oxidative stress and systemic inflammation. The aim of this study was to elucidate whether oxidative PM modification of ovalbumin (OVA), the major antioxidant serum protein, may...
Krzysztof Mucha,Michał Pac,Leszek Pączek
Krzysztof Mucha
During the last decade, thanks to omics technologies, new light has been shed on the pathogenesis of many diseases. Genomics, epigenomics, transcriptomics, and proteomics have helped to provide a better understanding of the origin and heter...
Domenico Ribatti
Domenico Ribatti
Mast cells are involved in tumor growth and their mediators exert both pro- and anti-tumorigenic roles in different human cancers. The identification of defined immunosuppressive pathways that are present in the tumor microenvironment has p...
Effect of Hematopoietic Stem Cell Transplantation and Post-Transplantation Cyclophosphamide on the Microglia Phenotype in Rats with Experimental Allergic Encephalomyelitis [0.03%]
造血干细胞移植和移植后环磷酰胺对实验性自身免疫性脑脊髓炎大鼠小胶质细胞表型的影响
Kaja Kasarełło,Martyna Seta,Dorota Sulejczak et al.
Kaja Kasarełło et al.
Microglia are the resident immune cells of the central nervous system, playing a role in the inflammatory process development and resolution, presenting two main phenotypes, pro-inflammatory M1, and anti-inflammatory M2. Therapies affecting...
Activating NKG2C Receptor: Functional Characteristics and Current Strategies in Clinical Applications [0.03%]
活化NKG2C受体的功能特点及临床应用现状与挑战
Jagoda Siemaszko,Aleksandra Marzec-Przyszlak,Katarzyna Bogunia-Kubik
Jagoda Siemaszko
The interest in NK cells and their cytotoxic activity against tumour, infected or transformed cells continuously increases as they become a new efficient and off-the-shelf agents in immunotherapies. Their actions are balanced by a wide set ...
The Effects of Statins on Respiratory Symptoms and Pulmonary Fibrosis in COVID-19 Patients with Diabetes Mellitus: A Longitudinal Multicenter Study [0.03%]
他汀类药物对糖尿病合并新冠肺炎患者呼吸系统症状及肺纤维化的影响：一项多中心纵向研究
Mohammadamin Sadeghdoust,Farnaz Aligolighasemabadi,Tania Dehesh et al.
Mohammadamin Sadeghdoust et al.
The aim of this prospective cohort study was to explore the effect of statins on long-term respiratory symptoms and pulmonary fibrosis in coronavirus disease 2019 (COVID-19) patients with diabetes mellitus (DM). Patients were recruited from...