Sanguinarine Inhibits Cell Growth in EBV-Positive Diffuse Large B-Cell Lymphoma [0.03%]
血根碱通过抑制EBER-p38-Mcl-1信号通路诱导阳性DLBCL细胞凋亡
Suli Lu,Dae-Jung Yang
Suli Lu
To investigate the effects of Sanguinarine (SAG) on the progression of diffuse large B-cell lymphoma (DLBCL) and to explore its underlying mechanism, this study utilized Epstein-Barr virus (EBV)-positive DLBCL cell lines, FARAGE, and GM1287...
Protective Effect of the Human Epineural Patch Application after Sciatic Nerve Crush Injury Followed by Nerve Transection and End-to-End Repair [0.03%]
坐骨神经挤压伤后神经切断及端端吻合的人 Epidural 补片的应用效果研究
Maria Siemionow,Weronika Radecka,Katarzyna Kozlowska et al.
Maria Siemionow et al.
Nerve regeneration under unfavorable wound conditions remains challenging. We introduce the human epineural patch (hEP) as a novel nerve protector for post-trauma applications, comparing its regenerative efficacy with that of the human amni...
Immunomodulatory Effect of the Bacillus Calmette-Guérin (BCG) Vaccine on the In Vitro Interferon Response Induced by Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antigens [0.03%]
卡介苗(Bacillus Calmette-Guérin, BCG)疫苗对呼吸道合胞病毒(Respiratory Syncytial Virus, RSV)和严重急性呼吸系统综合症冠状病毒2Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)抗原体外干扰素反应的免疫调节作用
Magdalena Jurczak,Joanna Kaczmarek,Magdalena Kowalewska-Pietrzak et al.
Magdalena Jurczak et al.
Studies on the bacillus Calmette-Guérin (BCG) vaccine, traditionally used against tuberculosis, indicate its potential benefit in protecting against infections. The vaccine's ability to broadly activate the immune system suggests its poten...
Isorhynchophylline Inhibits NLRP3 Inflammasome and Improves Gestational Diabetes [0.03%]
异弓藤碱通过抑制NLRP3炎症小体改善妊娠糖尿病
Li Pu,Li Chen,Kun Yu et al.
Li Pu et al.
This study aims to investigate the effects and underlying mechanisms of isorhynchophylline (IRN) on gestational diabetes mellitus (GDM). The db/+ mice were randomly divided into four groups: GDM, GDM + IRN (20 mg/kg), and GDM + IRN (40 mg/k...
Growing Challenges of Lung Infections with Non-tuberculous Mycobacteria in Immunocompromised Patients: Epidemiology and Treatment [0.03%]
免疫功能低下患者非结核分枝杆菌肺部感染的日益严峻挑战：流行病学和治疗
Weronika Burzyńska,Marek Fol,Magdalena Druszczynska
Weronika Burzyńska
Non-tuberculous mycobacteria (NTM) are increasingly recognized as opportunistic pathogens in humans and animals, particularly affecting those with compromised immune systems. These bacteria encompass a diverse group of mycobacterial species...
Nikita Niranjan Kumar,Samir Ahmad Dit Al Hakim,Bogna Grygiel-Górniak
Nikita Niranjan Kumar
Antinuclear antibodies (ANAs) are critical immunological markers commonly associated with various connective tissue diseases (CTDs). However, these autoantibodies are also detectable in healthy individuals, patients with non-rheumatic autoi...
CRISPR/Cas Systems as Diagnostic and Potential Therapeutic Tools for Enterohemorrhagic Escherichia coli [0.03%]
用于致病性大肠杆菌的诊断和潜在治疗工具的 CRISPR/Cas 系统
Agnieszka Bogut,Anna Kołodziejek,Scott A Minnich et al.
Agnieszka Bogut et al.
Following its discovery as an adaptive immune system in prokaryotes, the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) system has been developed into a multifaceted genome editing tool. ...
Quantification of Citrullinated Histone H3 as a Marker for Neutrophil Extracellular Traps Correlated to Clinical Characteristics of Patients with Systemic Lupus Erythematosus [0.03%]
作为系统性红斑狼疮患者细胞外陷阱标志物的瓜氨酸化组蛋白H3的量化与临床特征的相关性研究
Maciej Dubaj,Iwona Homa-Mlak,Aleksandra Majdan et al.
Maciej Dubaj et al.
Systemic lupus erythematosus (SLE) is an autoimmune disease whose pathogenesis is not fully understood to date. One of the suggested mechanisms for its development is NETosis, which involves the release of a specific network consisting of c...
Unraveling the Complexity and Advancements of Transdifferentiation Technologies in the Biomedical Field and Their Potential Clinical Relevance [0.03%]
解析生物医学领域转分化技术的复杂性和进展及其潜在临床意义
Purusottam Mishra,Izabella Biesiada,Payal Gupta et al.
Purusottam Mishra et al.
Chronic diseases such as cancer, autoimmunity, and organ failure currently depend on conventional pharmaceutical treatment, which may cause detrimental side effects in the long term. In this regard, cell-based therapy has emerged as a suita...
Barbara Moszczuk,Katarzyna Życińska,Krzysztof Mucha
Barbara Moszczuk
Hyperuricemia (HU) is a common disorder associated with gout, kidney injury, and high cardiovascular risk. However, whether high serum uric acid (sUA) is a causative factor or just comorbidity remains unclear. When asked if asymptomatic hyp...