Improvement of the experimental setup for skin absorption screening studies with reconstructed skin EPISKIN [0.03%]
改进重建皮肤（EPISKIN）体外吸收试验体系以进行皮肤吸收筛查研究
S Grégoire,C Patouillet,C Noé et al.
S Grégoire et al.
Percutaneous penetration studies are usually performed in human skin samples set up in a Franz cell device. The ability to perform these studies may depend on the availability of skin samples. Reconstructed skin models are an interesting al...
Comparative Study
Skin pharmacology and physiology. 2008;21(2):89-97. DOI:10.1159/000112959 2008
Influence of human skin specimens consisting of different skin layers on the result of in vitro permeation experiments [0.03%]
不同皮肤组织构型对体外透皮实验结果的影响研究
A Henning,D Neumann,K-H Kostka et al.
A Henning et al.
The literature exhibits high variation in results from drug permeation experiments across human skin. Our purpose was to investigate the influence of human skin specimens, consisting of different skin layers and resulting from different ski...
Comparative Study
Skin pharmacology and physiology. 2008;21(2):81-8. DOI:10.1159/000112958 2008
The role of emollients in the management of diseases with chronic dry skin [0.03%]
润肤剂在慢性干燥皮肤病治疗中的作用
E Proksch
E Proksch
Dry skin is a common skin condition as well as a key aspect of a number of diseases such as atopic dermatitis and psoriasis but also of other diseases and systemic conditions. Dry skin has an impact on the patient in terms of discomfort, pr...
Properties of ceramides and their impact on the stratum corneum structure. Part 2: stratum corneum lipid model systems [0.03%]
固醇类脂质的性质及其对角质层结构的影响。第二部分：角质层脂质模型系统
D Kessner,A Ruettinger,M A Kiselev et al.
D Kessner et al.
The stratum corneum (SC) represents the outermost layer of the mammalian skin, exhibits the main skin barrier and plays an important role in the water penetration pathway through the SC. Knowing the structure and properties of the SC at the...
The influence of a non-occlusive bi-layer composite membrane on skin barrier properties. A non-invasive evaluation with a right-left intra-individual pre/post comparison study [0.03%]
非封闭性双层复合膜对皮肤屏障性能的影响。一项使用右左对比研究的无创评估方法
V Brazzelli,E Berardesca,C Rona et al.
V Brazzelli et al.
The purpose of this placebo-controlled right-left intra-individual pre/post comparison study was to evaluate the efficacy of a new bi-layer composite membrane, composed of a layer of knitted cotton and a layer of semi-permeable polyurethane...
Comparative Study
Skin pharmacology and physiology. 2008;21(1):50-5. DOI:10.1159/000112519 2008
Topical delivery of retinyl ascorbate. 3. Influence of follicle sealing and skin stretching [0.03%]
维A醇抗坏血酸酯的经皮给药。3.皮脂腺密封和皮肤拉伸的影响
Kasem Abdulmajed,Charles M Heard
Kasem Abdulmajed
This influence of skin stretching and hair follicle sealing on the delivery of retinyl ascorbate (RA-AsA) to the epidermis was probed in vitro. Porcine ear skin was subjected to stretching by 2 and 4 mm (3.3 and 6.7%, respectively); the hai...
Comparative Study
Skin pharmacology and physiology. 2008;21(1):46-9. DOI:10.1159/000111135 2008
Placebo-controlled, double-blind, randomized, prospective study of a glycerol-based emollient on eczematous skin in atopic dermatitis: biophysical and clinical evaluation [0.03%]
特应性皮炎患者斑片试验用甘油润肤剂的自身前后对照、双盲随机化研究：生物物理和临床评价
M Breternitz,D Kowatzki,M Langenauer et al.
M Breternitz et al.
Background/aims: Atopic dermatitis (AD) is a frequent, chronic inflammatory disease influenced by local, immunological, genetic and environmental factors. Important symptoms of AD are dry skin, intense pruritus and impair...
Clinical Trial
Skin pharmacology and physiology. 2008;21(1):39-45. DOI:10.1159/000111134 2008
In vivo and in vitro skin permeation of butyl methoxydibenzoylmethane from lipospheres [0.03%]
包裹薄荷脑茋双酯脂质体的制备及其透皮性能评价
V Iannuccelli,G Coppi,S Sergi et al.
V Iannuccelli et al.
Lipid microparticles (lipospheres) loaded with butyl methoxydibenzoylmethane (BMDBM), a widely used UV-A sunscreen agent, were prepared by melt technique and evaluated for skin permeation both in vivo, by tape stripping method, and in vitro...
Comparative Study
Skin pharmacology and physiology. 2008;21(1):30-8. DOI:10.1159/000109656 2008
P Klinubol,P Asawanonda,S P Wanichwecharungruang
P Klinubol
A penetration study of 2-ethylhexyl-4-methoxycinnamate (EHMC), 4-methyl benzylidenecamphor (MBC), butyl methoxydibenzoylmethane (BMBM), 2-ethylhexyl-2,4,5-trimethoxycinnamate (EHTMC) and di(2-ethylhexyl)-2,4,5-trimethoxybenzalmalonate (TMB)...
Comparative Study
Skin pharmacology and physiology. 2008;21(1):23-9. DOI:10.1159/000109085 2008
Molecular basis for the regenerative properties of a secretion of the mollusk Cryptomphalus aspersa [0.03%]
来源于蜗牛Cryptomphalus aspersa的分泌物促再生的作用机制研究
A Brieva,N Philips,R Tejedor et al.
A Brieva et al.
A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular...
Comparative Study
Skin pharmacology and physiology. 2008;21(1):15-22. DOI:10.1159/000109084 2008