Lateral Dermal Penetration Is Dependent on the Lipophilicity of Active Ingredients [0.03%]
穿透力与有效成分的 lipophilicity 有关
Markus Lubda,Maximilian Zander,Andrew Salazar et al.
Markus Lubda et al.
Introduction: With its large surface area, skin facilitates a topical administration of active ingredients, and thus percutaneous delivery to a specific target site. Due to its high barrier function and different diffusio...
RP-18 TLC and Computational Descriptors of Skin Permeability of Sunscreens [0.03%]
RP-18 TLC及防晒剂皮肤渗透性的计算描述符
Anna W Sobańska,Elżbieta Brzezińska
Anna W Sobańska
The relationships between the reversed-phase thin layer chromatographic retention parameters obtained on octadecyl-modified silica (RP-18) sorbent for mobile phases containing water and one of six water-miscible organic modifiers (acetone, ...
Common Cosmetic Compounds Can Reduce Air Pollution-Induced Oxidative Stress and Pro-Inflammatory Response in the Skin [0.03%]
常见化妆品成分可减轻空气污染引起的皮肤氧化应激和促炎反应
Kristýna Hergesell,Kateřina Valentová,Vladimír Velebný et al.
Kristýna Hergesell et al.
Introduction: Constantly increasing air pollution (AP) poses a concern affecting not only our health but also our skin. A typical manifestation of the skin damage induced by AP is its premature aging, irritation, skin bar...
An Exploratory Study of the Effects of the pH of Synthetic Urine on Skin Integrity in Healthy Participants [0.03%]
生理盐水和不同pH值的人工尿对志愿者皮肤影响的探索性研究
Sofoklis Koudounas,Dan L Bader,David Voegeli
Sofoklis Koudounas
Background: Incontinence-associated dermatitis (IAD) develops from prolonged exposure of skin to urine and/or stool and represents a common complication in older adults, reducing the quality of life. Increased pH is an im...
Association of Sensitive Eyes with Sensitive Skin: A Worldwide Study of 10,743 Subjects [0.03%]
敏感眼睛与敏感皮肤的关联：一项针对10743名受试者的研究
Laurent Misery,Annabelle Reaux-Le Goazigo,Stéphane Morisset et al.
Laurent Misery et al.
Introduction: Sensitive eyes are commonly reported by patients, but there are very few epidemiological studies on this disorder. The aim of this study was the evaluation of the self-reported frequency of sensitive eyes an...
Current Views on Noninvasive in vivo Determination of Physiological Parameters of the Stratum Corneum Using Confocal Raman Microspectroscopy [0.03%]
共焦拉曼显微光谱法无创检测皮脂层生理参数的研究进展
Maxim E Darvin,Johannes Schleusener,Jürgen Lademann et al.
Maxim E Darvin et al.
Confocal Raman microspectroscopy is widely used in dermatology and cosmetology for analysis of the concentration of skin components (lipids, natural moisturizing factor molecules, water) and the penetration depth of cosmetic/medical formula...
Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled in vitro [0.03%]
甲福明促进表皮和真皮细胞三维聚合体的生发诱导活性这些聚合体是在体外自我组装的
Chao Sun,Shuang-Hai Hu,Bing-Qi Dong et al.
Chao Sun et al.
Introduction: Although it has been reported that the antidiabetic drug metformin has multiple extra-hypoglycemic activities, such as anti-oxidation, antiaging, and even antitumor, topical metformin also can induce hair re...
Melanogenesis Markers Expression in Premature Graying of Hair: A Cross-Sectional Study [0.03%]
早白发的黑素生成标志物表达：一项横断面研究
Ranugha Pss,Subbarao V Madhunapantula,Jayadev B Betkerur et al.
Ranugha Pss et al.
Background: Studies on mice and aging human hair follicles provide compelling evidence that graying of hair results from premature differentiation of melanocyte stem cells in the niche/bulge. ...
A Biomimetic Combination of Actives Enhances Skin Hydration and Barrier Function via Modulation of Gene Expression: Results of Two Double-Blind, Vehicle-Controlled Clinical Studies [0.03%]
活性生物仿生组合通过调节基因表达增强皮肤水分和屏障功能：两项双盲、安慰剂对照临床研究的结果
Silke Altgilbers,Frank Rippke,Alexander Filbry et al.
Silke Altgilbers et al.
Introduction: Xerosis cutis is characterized by a decreased stratum corneum (SC) hydration and an impaired skin barrier function. Urea, the most prevalent natural moisturizing factor (NMF), is currently considered the gol...
Randomized Controlled Trial
Skin pharmacology and physiology. 2022;35(2):102-111. DOI:10.1159/000520009 2022
Influence of Janus Kinase Inhibitors on the Neuronal Activity as a Proof-of-Concept Model for Itch [0.03%]
锦斯酸抑制剂对神经元活动的影响作为一个瘙痒的概念验证模型
Johannes Wohlrab,David Stintzing,Luise Schultz et al.
Johannes Wohlrab et al.
Background: Itching is considered to be a subjective symptom of the activation of neurosensory structures by different signal molecules and trigger factors. The signaling cascades responsible for it are closely linked to ...