A Phase I Study to Evaluate the Safety and Pharmacokinetics of SHR0302 Base Ointment in Healthy Adult Volunteers [0.03%]
评估健康成年志愿者使用SHR0302基软膏的安全性和药代动力学的I期研究
Baoping Li,Nanyang Li,Aik Han Goh et al.
Baoping Li et al.
Introduction: SHR0302 is a highly selective JAK1 inhibitor. This study aimed to investigate the safety, tolerability, and pharmacokinetics of single and multiple-dose topical skin application of SHR0302 base ointment in h...
Clinical Trial
Skin pharmacology and physiology. 2023;36(2):76-86. DOI:10.1159/000528739 2023
Development of an Efficient Extraction Methodology to Analyse Potential Inflammatory Biomarkers from Sebum [0.03%]
有效分析皮脂中潜在炎性生物标志物的提取方法的开发
Hemalatha Jayabal,Dan L Bader,Peter Worsley
Hemalatha Jayabal
Introduction: Proteins, such as cytokines and chemokines, are present in varying concentrations in a range of biofluids, with an important signalling role in maintaining homeostasis. Commercial tapes have been employed to...
Trichoscopic Diagnosis of Structural Hair Defects in a Clinical Setting: A Cross-Sectional Analytical Study [0.03%]
临床设置中毛发结构缺陷的镜诊断 ：一项横断面分析研究
Rania Abdel Hay,Khadiga S Sayed,Wedad Z Mostafa et al.
Rania Abdel Hay et al.
Background: Trichoscopy is a simple, noninvasive procedure practiced in the diagnosis of a multitude of scalp and hair disorders. Hair shaft abnormalities usually represent a diagnostic challenge to dermatologists. ...
Dermal and Transdermal Macromolecule Delivery Using Enhancer Molecules and Colloidal Carrier Systems - Part 2: Percutaneous Administration of Heparin [0.03%]
使用增强分子和胶体载体系统进行皮肤及经皮给药大分子-第2部分：肝素的经皮给药
Jamal Alyoussef Alkrad,Yousif Ali Almalki,Eman Zmaily Dahmash et al.
Jamal Alyoussef Alkrad et al.
Introduction: Heparin is a commonly used anti-coagulant administered either by intravenous or subcutaneous injection for a systemic effect or topically for the treatment of peripheral vascular disorders. ...
Free Fatty Acids Induce Lipid Accumulation, Autophagy, and Apoptosis in Human Sebocytes [0.03%]
游离脂肪酸诱导人类皮脂腺细胞脂质沉积 自噬和凋亡
Amir M Hossini,Xiaoxiao Hou,Tarik Exner et al.
Amir M Hossini et al.
Background: A disruption of sebocyte differentiation and lipogenesis has fatal consequences and can cause a wide spectrum of skin diseases, from acne vulgaris to sebaceous carcinoma, however, the relevant molecular mechan...
Topically Confined Enhancement of Cutaneous Microcirculation by Cold Plasma [0.03%]
冷等离子体对皮肤微循环的局部增强作用
Thomas Borchardt,Andreas Helmke,Jennifer Ernst et al.
Thomas Borchardt et al.
Introduction: We aim to explore potentials and modalities of cold atmospheric pressure plasma (CAP) for the subsequent development of therapies targeting an increased perfusion of the lower leg skin tissue. In this study,...
Challenges in Noninvasive Skin Biomarker Measurements in Daily Practice: A Longitudinal Study on Skin Surface Protein Detection by the Transdermal Analysis Patch in Pediatric Psoriasis [0.03%]
实用中非侵入性皮肤生物标志物测量的挑战：一项关于透皮分析贴片在儿科银屑病患者中检测皮肤表面蛋白的纵向研究
Mirjam J Schaap,Finola M Bruins,Noa J M van den Brink et al.
Mirjam J Schaap et al.
Introduction: Skin surface proteins are potential biomarkers in psoriasis and can be measured noninvasively with the transdermal analysis patch (TAP). This study aimed to assess markers measured by TAP over time in daily ...
Observational Study
Skin pharmacology and physiology. 2022;35(6):319-327. DOI:10.1159/000527258 2022
Direct and Indirect Effects of Blue Light Exposure on Skin: A Review of Published Literature [0.03%]
蓝光对皮肤的直接与间接影响：已发表文献综述
Orawan Suitthimeathegorn,Cheng Yang,Yanyun Ma et al.
Orawan Suitthimeathegorn et al.
Background: The growing use of electronic devices and other artificial light sources in recent decades has changed the pattern of exposure to blue light (400-500 nm). Although some progress has been made in the study of t...
Sinomenine Suppressed Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis by Regulating lncRNA XIST [0.03%]
蔓荆碱通过调节长链非编码RNA XIST抑制角质细胞增殖和咪喹莫德诱导的银屑病样皮炎
Shoubao Xiang,Xing Wu,Yu Xiang
Shoubao Xiang
Background: Psoriasis is a chronic inflammatory skin disease. Sinomenine (SIN) has anti-inflammatory and antioxidant effects. Objective: ...
Acidic Skin Care Promotes Cutaneous Microbiome Recovery and Skin Physiology in an Acute Stratum Corneum Stress Model [0.03%]
酸性护肤品通过促进急性角质层压力模型中的皮肤微生态恢复从而改善皮肤生理功能
Joachim W Fluhr,Peter Menzel,Rolf Schwarzer et al.
Joachim W Fluhr et al.
Introduction: Skin microbiome and skin physiology are important indicators of the epidermal homeostasis status. Stress models can reveal pathological conditions and modulating effects. Here we investigated the cutaneous m...