Antidiabetic Effects of Ecklonia cava and Dieckol via DPP-IV Inhibition and Glucose Transport Regulation [0.03%]
Ecklonia cava和Dieckol通过DPP-IV抑制及葡萄糖转运调节的降血糖作用
Indyaswan T Suryaningtyas,Nabila Shafura,Ratih Pangestuti et al.
Indyaswan T Suryaningtyas et al.
Brown seaweeds are recognized for their rich content of phlorotannins with promising antidiabetic properties through multi-targeted modulation of glucose metabolism. This study investigated the antidiabetic potential of the ethyl acetate fr...
Marine Natural Products as Potent Anticancer Agents (2020-2024): Structural Diversity, SARs and Target Prediction [0.03%]
海洋天然产物作为潜在的抗肿瘤药物（2020-2024）：结构多样性、构效关系和靶点预测
Zimeng Huang,Yijing Du,Junzhe Hu et al.
Zimeng Huang et al.
In recent years, Marine Natural Products (MNPs) have emerged as a significant source for anticancer drug discovery, as many natural products can offer structural diversity, unique mechanisms of action, and relatively low toxicity. This arti...
Multi-Omics Reveals Tetrodotoxin Transport and Accumulation Mechanisms in Takifugu bimaculatus [0.03%]
多组学揭示河豚鱼福寿螺中河豚毒素的运输和积累机制
Xinxin Zhang,Min Xu,Jiapeng Qi et al.
Xinxin Zhang et al.
The potent toxicity of tetrodotoxin (TTX) has long constrained sustainable growth in pufferfish aquaculture. Takifugu bimaculatus, an economically important species farmed along the coast of Fujian, China, remains poorly understood regardin...
Bioactive Compounds from Microalgae and Cyanobacteria: Evaluation of Their Antioxidant and Antimicrobial Activities [0.03%]
微藻和蓝藻的生物活性化合物：其抗氧化和抗菌活性评价
Bruna de Falco,Carlos José Martel-Benítez,Carlos Almeida et al.
Bruna de Falco et al.
Microalgae hold great potential towards pharmaceutical and nutraceutical sectors due to their substantial content of highly functional bioactive compounds. To assess their potential as a sustainable source of valuable products, 10 cyanobact...
Marine Bioactive Peptides for Colorectal Cancer Therapy: Mechanisms, Therapeutic Potential, and Translational Challenges [0.03%]
海洋生物活性肽在结直肠癌治疗中的作用机制、治疗潜力及转化挑战
Yueyang Lu,Guixiao Wang,Mei Zhou et al.
Yueyang Lu et al.
Colorectal cancer (CRC) is one of the most prevalent gastrointestinal malignancies worldwide and remains a major cause of cancer-related mortality. Although current treatment strategies, including surgery, chemotherapy, radiotherapy, and ta...
Metformin-like Methylglyoxal Scavengers from Macroalgae Chondrus crispus and Gracilaria vermiculophyla Preserve Cell Viability [0.03%]
从红藻溶石菜和皱纹龟裂藻中鉴定出的具有降糖活性的甲基乙二醛清除剂化合物
George S Hanna,Menny M Benjamin,Latarsha Porcher et al.
George S Hanna et al.
A quantitative NMR assay was utilized to identify methylglyoxal-scavenging natural products from Rhodophytes, Chondrus crispus and Gracilaria vermiculophylla. This revealed the activity of guanylurea-containing amino acid derivatives, gongr...
Isolation and Characterization of St-CRPs: Cysteine-Rich Peptides from the Arctic Marine Ascidian Synoicum turgens [0.03%]
Ida K Ø Hansen,Philip B Rainsford,Johan Isaksson et al.
Ida K Ø Hansen et al.
Ascidians are a group of marine invertebrates, most of which are sessile and soft-bodied. Their lack of an adaptive immune system makes them rely on innate immune responses to detect and eliminate invading microbes. Antimicrobial peptides (...
Convergent Total Synthesis of PM742 and SAR-Guided Development of the Clinical Candidate PM534 [0.03%]
PM742的汇聚式全合成及基于结构活性关系引导的临床候选药物PM534的设计开发
María Jesús Martín,Juan Hernando,Raquel Rodríguez-Acebes et al.
María Jesús Martín et al.
We report the first total synthesis of PM742 using N-Boc-D-Norvaline and 2-Methyl-L-Cysteine hydrochloride as starting materials in a convergent sequence of eight chemical steps. This strategy provides efficient access to PM742 and enables ...
Long-Chain n-3 Polyunsaturated Fatty Acids Attenuate the Severity of Obesity-Associated White Adipose Tissue and Skeletal Muscle Dysfunction [0.03%]
长链n-3多不饱和脂肪酸可减轻肥胖相关白色脂肪组织和骨骼肌功能障碍的严重性
Ala Alzubi,Alyssa Lucchesi,Jessie L Burns et al.
Ala Alzubi et al.
Obesity is a complex metabolic disorder defined by a body mass index greater than 30 kg/m2, excess adipose tissue accumulation, chronic low-grade inflammation and metabolic dysfunction, leading to increased susceptibility to other chronic c...
Research Progress on Marine Active Substances in Improving Atherosclerosis [0.03%]
海洋活性物质改善动脉粥样硬化的研究进展
Chenyang Xie,Jiapeng Qi,Wenmei Huang et al.
Chenyang Xie et al.
Atherosclerosis is the primary pathological foundation of various cardiovascular and cerebrovascular diseases. Although existing treatment strategies exhibit certain efficacy, they still encounter limitations such as pronounced side effects...