A Robust Marine Collagen Peptide-Agarose 3D Culture System for In Vitro Modeling of Hepatocellular Carcinoma and Anti-Cancer Therapeutic Development [0.03%]
一种用于体外肝癌建模和抗癌药物开发的稳健型海洋胶原肽-琼脂糖三维培养体系
Lata Rajbongshi,Ji-Eun Kim,Jin-Eui Lee et al.
Lata Rajbongshi et al.
The development of physiologically relevant three-dimensional (3D) culture systems is essential for modeling tumor complexity and improving the translational impact of cancer research. We established a 3D in vitro model of human hepatocellu...
Progress in the Application of Marine Polysaccharide Drug Delivery Systems in Tumor Immunotherapy: Multiple Mechanisms and Material Forms [0.03%]
海洋多糖药物递送系统在肿瘤免疫治疗应用进展：多重机制与材料形式
Mingxue Cha,Shuqiang Yan,Yiping Zhang et al.
Mingxue Cha et al.
Tumor immunotherapy, a revolutionary cancer treatment, is hindered by inadequate immune cell activation, immunosuppressive tumor microenvironment (TME), and off-target toxicities of immunotherapeutics. These bottlenecks necessitate innovati...
A Stable Delivery System for Meretrix meretrix Derived Immunomodulatory Peptide (QLNWD): Fabrication and Characterization of Glycosylated Protein Nanoparticle [0.03%]
来自梅氏珠母贝免疫调节肽（QLNWD）的稳定递送系统：甘露糖修饰蛋白纳米颗粒的制备及表征
Wanyi Wu,Zhixuan Wu,Jiamin Cai et al.
Wanyi Wu et al.
In this study, nanoparticles prepared by the heat-induced self-assembly of bovine serum albumin-dextran conjugates (BSA-DX) were utilized as an effective delivery system for the immunoregulatory peptide Gln-Leu-Asn-Trp-Asp (QLNWD) from Mere...
Sustainable and Integral Valorization of Dosidicus gigas Pen Waste: Combined Production of Chitosan with Antibacterial Properties and Human and Marine Probiotics [0.03%]
秘鲁鱿鱼笔废弃资源的可持续及综合利用：具有抗菌性能壳聚糖与人和海洋用 probiotics 的联产技术研究进展
Marta Lima,Adrián Pedreira,Noelia Sanz et al.
Marta Lima et al.
This study details a biorefinery approach to valorize Dosidicus gigas squid pen waste. The process starts with the enzymatic deproteinization of squid pens, which prove effective with both Alcalase and Novozym, with the latter exhibiting a ...
Ecological Characteristics and Nutritional Values of Australia-Native Brown Algae Species [0.03%]
澳大利亚本土褐藻物种的生态特征及营养价值
Chao Dong,Cundong Xie,Ziqi Lou et al.
Chao Dong et al.
This review focuses on five native Australian brown algae species-Cystophora torulosa, Durvillaea potatorum, Ecklonia radiata, Hormosira banksii, and Phyllospora comosa-evaluating their environmental adaptability, biochemical composition, b...
A Sulfated Polysaccharide from Gelidium crinale Suppresses Oxidative Stress and Epithelial-Mesenchymal Transition in Cultured Retinal Pigment Epithelial Cells [0.03%]
石莼科角叉菜提取的硫酸多糖通过抑制氧化应激和上皮间质转化保护培养的视网膜色素上皮细胞
Yurong Fang,Haiyan Zheng,Yizhu Chen et al.
Yurong Fang et al.
Age-related macular degeneration (AMD) progresses to vision-threatening dry and wet forms, with no effective dry AMD treatments available. The sulfated polysaccharide (GNP, 25.8 kDa) derived from Gelidium crinale exhibits diverse biological...
The Marine Natural Compound Aplysinamisine I Selectively Induces Apoptosis and Exhibits Synergy with Taxol™ in Triple-Negative Breast Cancer Spheroids [0.03%]
海洋天然产物aplisinamisine I能够选择性地诱导三阴乳腺癌类器官凋亡并可与紫杉醇联合使用产生增效作用
Esther A Guzmán,Tara A Peterson,Dedra K Harmody et al.
Esther A Guzmán et al.
Triple-negative breast cancers (TNBC) lack estrogen, progesterone, and express little, if any, HER2 receptors on their surface. No targeted therapies exist for this aggressive form of breast cancer. A library of enriched fractions from mari...
Characterization of YKL-40 Binding to Extracellular Matrix Glycosaminoglycans [0.03%]
YKL-40与细胞外基质糖胺聚糖结合表征
Unnur Magnusdottir,Yiming Yang Jonatansdottir,Kristinn R Oskarsson et al.
Unnur Magnusdottir et al.
YKL-40 is a chitinase-like glycoprotein implicated in various pathological processes, yet its glycosaminoglycan (GAG) binding profile beyond heparin has not been examined. In this study, we performed a Microscale Thermophoresis (MST) analys...
Phytochemistry and Pharmacological Potential of the Mangrove Plant Sonneratia caseolaris: A Comprehensive Review [0.03%]
综述：桐油林植物索诺拉提亚(caseolaris)的植物化学和药理潜力
Federico Cerri,Paolo Galli
Federico Cerri
Mangroves represent a promising yet underexplored source of natural products. Sonneratia caseolaris (mangrove apple) is a widely distributed species with a long history of use in traditional medicine, and it is receiving increasing recognit...
Novel Cyclic Tetrapeptides as Neuraminidase Inhibitors from a Sponge-Associated Penicillium sp. SCSIO41035 [0.03%]
一种海绵关联真菌Penicillium sp. SCSIO41035所产生 cyclic tetrapeptide 类神经氨酸酶抑制剂新型活性代谢产物的研究
Weihao Chen,Xiangliu Chen,Mengjing Cong et al.
Weihao Chen et al.
Four new compounds and three new natural products (1-7), including three novel cyclic tetrapeptides (penicopeptides B-D), along with three known spiroquinazoline analogs (8-10), were isolated from rice medium cultures of a sponge-associated...