Anti-Proliferative Effect on Medulloblastoma of Small Metabolites Derived from Staurosirella pinnata (Bacillariophyta) Exposed to Different Irradiances [0.03%]
不同光照条件下产生小代谢物的舟形藻（硅藻）对髓母细胞瘤增殖的影响
Saverio Savio,Michela Sodini,Matteo Odorisio et al.
Saverio Savio et al.
An isolate of the diatom Staurosirella pinnata is a promising platform for drug discovery due to its ability to produce bioactive metabolites. As previously shown, S. pinnata extracts exhibit bioactivities, with hydrophilic fractions showin...
Discovery of New Zosteropenillines from the Seagrass-Derived Fungus Penicillium yezoense KMM 4679 by OSMAC Strategy [0.03%]
通过优化合成分析策略从海草来源的Penicillium yezoense KMM 4679真菌中发现新型Zosteropenilline类化合物
Elena V Leshchenko,Gleb V Borkunov,Alexandr S Antonov et al.
Elena V Leshchenko et al.
Thirteen new decaline polyketides, namely, zosteropenillines T-W (1-4), 8-hydroxypallidopenilline A (5), 13-epi-zosteropenilline P (6), 11-epi-zosteropenilline N (7), 15-hydroxyzosteropenilline M (8), 8-hydroxyzosteropenilline M (9), 11-epi...
Identification of Novel Anti-Inflammatory Peptides from Jellyfish Nemopilema nomurai Enzymatic Hydrolysate: An Integrated In Silico Analysis and Cellular Evaluation [0.03%]
基于 Nomura 泽被水母酶解物的新型抗炎肽的鉴定：一种集成的计算和细胞分析方法
Wen Shen,Xueqin Wang,Rongfeng Li et al.
Wen Shen et al.
Inflammation plays a critical role in host defense and tissue repair; however, excessive or dysregulated inflammatory responses can lead to tissue damage and contribute to the progression of various diseases. Jellyfish-derived peptides have...
Floridoside as a Hinge-Targeted Inhibitor of MAPK13: Atomistic Insights from Molecular Dynamics Simulations [0.03%]
分子动力学模拟研究：作为MAPK13支点靶向抑制剂的floridoside的原子级见解
Yang Zhong,Feng Liang,Zhongli Xiong et al.
Yang Zhong et al.
Floridoside (2-(α-D-galactosyl)glycerol) is a compatible solute synthesized in red algae, known for its antioxidant, immunostimulatory, anti-inflammatory, and antimicrobial properties. However, the lack of target validation has limited mec...
Manzamine-A: Unraveling the Chemical and Biological Tapestry of a Marine-Derived Drug Lead [0.03%]
解开海洋药物先导曼扎米宁A的化学与生物之谜
Xuan Wang,Hengbo Wang,Yuansai Kang et al.
Xuan Wang et al.
Manzamine-A (MA), a complex β-carboline alkaloid isolated from various genera of marine sponges, has attracted significant attention due to its unique structure and broad spectrum of potent biological activities. Despite the therapeutic po...
GV-971 Ameliorates Chronic Restraint Stress-Induced Depression-like Phenotypes Accompanied by Reshaping of the Microbiota-Gut-Brain Axis [0.03%]
GV-971通过重塑肠-脑轴缓解慢性束缚应激引起的抑郁样行为及相关肠道菌群改变
Zhuandi He,Yali Nie,Changcai Li et al.
Zhuandi He et al.
Depression is increasingly linked to microbiota-gut-brain axis dysfunction, yet current monoaminergic antidepressants show limited efficacy. This study investigated the therapeutic potential and underlying mechanisms of GV-971, a marine-der...
Ether Phosphatidylserine from Soft Coral Sclerophytum heterospiculatum Reveals Antioxidant Activity and Modulates Lipid Composition in LPS-Activated Human Microglial HMC-3 Cells [0.03%]
来自软珊瑚Sclerophytum heterospiculatum的乙醚磷脂酰丝氨酸表现出抗氧化活性并调节LPS激活的人类小胶质细胞HMC-3中的脂质组成
Elena T Bizikashvili,Arina I Ponomarenko,Ekaterina V Ermolenko et al.
Elena T Bizikashvili et al.
Ether phospholipids from marine organisms represent an understudied class of bioactive lipids with unique structural features. In this study, we isolated, for the first time, an ether phosphatidylserine (ePS) species from the soft coral Scl...
Equinatoxin II: How a Cationic Pore-Forming Sea Anemone Toxin Drives Nodal Swelling of Myelinated Nerve Fibers [0.03%]
equinatoxin II：带正电的孔形成海葵毒素如何驱动髓鞘神经纤维结节肿胩
Evelyne Benoit,Robert Frangež,Gilles Ouanounou et al.
Evelyne Benoit et al.
This study was performed to elucidate the mechanism underpinning the nodal swelling induced by equinatoxin II (EqtII), a cation-selective pore-forming toxin derived from the sea anemone Actinia equina. Experiments were conducted using frog ...
Fucoidan Oligosaccharides from Kjellmaniella crassifolia Ameliorate Ulcerative Colitis by Regulating the TLR4 and NF-κB Signaling Pathway and Modulating Gut Microbiota [0.03%]
海带多糖寡糖通过调节Tlr4和NF-κB信号通路及调控肠道菌群治疗溃疡性结肠炎
Zhiying Xu,Zheyu Jia,Liu Li et al.
Zhiying Xu et al.
Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD), which is marked by severe abdominal pain, weight loss, perianal bleeding, and diarrhea. This study successfully isolated and purified four low-molecular-weight fucoidan ...
Algae-Derived Bioactives Reprogram the Gut-SIRT1-Kisspeptin Axis in Polycystic Ovary Syndrome [0.03%]
藻类活性物质调节多囊卵巢综合征的肠道-SIRT1-亲吻肽轴
Arifa Mustika,Era Gorica,Dante Saksono Harbuwono et al.
Arifa Mustika et al.
Polycystic ovary syndrome (PCOS) is increasingly recognized as a complex, multi-system disorder involving interactions among metabolic dysfunction, chronic low-grade inflammation, and neuroendocrine dysregulation, rather than a condition co...