Comprehensive Pharmacokinetics of the Marine-Derived PDE4 Inhibitor LY104 and Its Major Metabolite M1 in Rats: A Validated LC-MS/MS Method with Sex Comparison, Multiple-Dose, Protein Binding, Metabolic Stability, and Excretion Studies [0.03%]
LY104及其主要代谢产物M1在大鼠体内的药物动力学研究：一种经性别比较、多剂量给药、蛋白结合力、代谢稳定性和排泄研究验证的LC-MS/MS方法
Xiaochen Niu,Jun Zhao,Deqi Ding et al.
Xiaochen Niu et al.
LY104 (previously designated as B7) is a selective phosphodiesterase 4 inhibitor with promising activity against chronic obstructive pulmonary disease. We previously reported its single-dose pharmacokinetics and tissue distribution in rats....
New Cytotoxic Anthraquinone Derivatives from a Deep-Sea-Derived Aspergillus sp. SCSIO 41331 [0.03%]
来源于深海曲霉菌SCSIO 41331的新 cytotoxic蒽醌衍生物
Ziyi Wu,Zehan Zheng,Weimao Zhong et al.
Ziyi Wu et al.
Two new anthraquinone derivatives, (±)-1'-O-methyl-6-chloroaverantin (1a and 1b) and 6-chloroaverythrin (2), and one new diphenyl ether 1-((E)-but-2-en-2-yl)-3,8-dihydroxy-6-((E)-4-hydroxybut-2-en-2-yl)-4,9-dimethyl-11H-dibenzo[b,e][1,4]di...
Ascophyllan Supplementation Is Safe and Associated with Exploratory Modulation of Innate Immune Phenotypes, Biochemical Parameters, and the Gut Microbiome in a Randomized Pilot Trial [0.03%]
一种名为Ascophyllan的补充剂在随机初步试验中被证明是安全的，并且与先天免疫表型、生化参数和肠道微生物群的探索性调节有关。
Shohei Mizuno,Jorge Luis Espinoza,Lam Quang Vu et al.
Shohei Mizuno et al.
Background: Ascophyllan, a sulfated polysaccharide extracted from brown seaweed, has shown immunomodulatory and antioxidant effects in preclinical studies, yet human clinical evidence remains scarce. This randomized, doub...
Randomized Controlled Trial
Marine drugs. 2026 Jun 15;24(6):213. DOI:10.3390/md24060213 2026
Daniela Giordano
Daniela Giordano
Marine organisms represent an extraordinary source of chemically diverse natural products that confer key adaptive advantages, such as antimicrobial defense and communication within complex ecological networks [...].
Editorial
Marine drugs. 2026 Jun 15;24(6):212. DOI:10.3390/md24060212 2026
Cebulactam A3, a Macrolactam from Marine-Derived Saccharopolyspora sp. PG10, and Its Antibacterial Activity [0.03%]
来源于海洋来源Saccharopolyspora sp. PG10中的_cebulactam A3及其抗菌活性
Chan Kim,Thinh T M Bui,Hyeongju Jeong et al.
Chan Kim et al.
Chemical analysis of the marine-derived Saccharopolyspora sp. PG10 led to the isolation of a novel macrolactam, cebulactam A3 (1), along with four known congeners, cebulactams A1 and A2 (2 and 3) and shengliangmycins B and D (4 and 5). The ...
Low-Level Domoic Acid Exposure Induces Age-like Cardiomyopathy in Young Adult and Aged Mice [0.03%]
低水平石房蛤毒素暴露可诱导年轻成人和老龄小鼠出现老年型心肌病
Sophia Liu,Alicia Hendrix,James MacDonald et al.
Sophia Liu et al.
Domoic acid (DA) is a well-known seafood toxin produced by some species of marine phytoplankton in the genus Pseudo-nitzschia during harmful algal blooms (HABs). Acute toxic exposures induce overt clinical signs of neuroexcitotoxicity, such...
DHA-Derived Lipid Mediators Attenuate Osteoarthritis by Resolving Inflammation and Protecting Cartilage in Association with the SIRT1 Signaling Pathway [0.03%]
与SIRT1信号通路相关联的通过解决炎症和保护软骨来缓解骨关节炎的DHA衍生脂质介质
Yan Su,Soon Kyu Kwon,Hack Sun Choi et al.
Yan Su et al.
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by persistent low-grade inflammation and progressive cartilage destruction. Macrophage-driven inflammatory responses contribute to extracellular matrix (ECM) degradat...
Research Progress on Polyphenols and Polysaccharides from Marine Seaweeds: Promising Diabetes Management Natural Products [0.03%]
海洋褐藻多酚和多糖的研究进展：有前景的糖尿病管理天然产物
Yiqiao Wang,Zhiyu Lin,Haiying Zhang et al.
Yiqiao Wang et al.
Type 2 diabetes mellitus (T2DM) is a major global health burden characterized by insulin resistance, progressive pancreatic β-cell dysfunction, and chronic metabolic dysregulation. Marine seaweeds have emerged as a valuable source of bioac...
Selected Alien Macroalgae Species from Madeira Archipelago as a Source of Sustainable Antifungal and Elicitor Agents: A Review on Their Valorization Potential and Green Extraction Approaches [0.03%]
马德拉群岛所选外来大型海藻种类作为可持续抗真菌和诱导剂来源的潜力及绿色提取方法综述
Emmanuel Nunes,Nuno Nunes,Miguel  A Pinheiro de Carvalho
Emmanuel Nunes
Non-indigenous or alien macroalgae are increasingly recognized as ecological threats, sources of raw material, and reservoirs of bioactive compounds for industry and agriculture. This review analyses the valorization potential of this bioma...
New Bicyclic Sesquiterpene and Labdane Diterpenes from the Culture Extract of the Sea Grass-Derived Fungus Penicillium verruculosum KUFA1509 [0.03%]
来源于海草分离内生真菌Penicillium verruculosum KUFA1509的代谢产物研究
Diana I C Pinho,Tida Dethoup,Ruchiluk Rattarom et al.
Diana I C Pinho et al.
An unreported bicyclic sesquiterpene acid, verruculosic acid (1), was isolated together with the previously reported labdane diterpenes, (+)-agathic acid (2a) and hypoxyterpenoid A (2b), one 3-nor-2,3-seco-labdane, penioxalicin (3), and 5-c...