The Inhibition Effect and Mechanism of Staurosporine Isolated from Streptomyces sp. SNC087 Strain on Nasal Polyp [0.03%]
来自SNC087链霉菌的Staurosporine对鼻息肉的抑制作用和机制研究
Grace Choi,Eun-Young Lee,Dawoon Chung et al.
Grace Choi et al.
This study aims to explore the potential inhibition effects of staurosporine isolated from a Streptomyces sp. SNC087 strain obtained from seawater on nasal polyps. Staurosporine possesses antimicrobial and antihypertensive activities. This ...
New Polyene Macrolide Compounds from Mangrove-Derived Strain Streptomyces hiroshimensis GXIMD 06359: Isolation, Antifungal Activity, and Mechanism against Talaromyces marneffei [0.03%]
来自海洋微生物Streptomyces hiroshimensis GXIMD 06359的新聚烯大环内酯类化合物：分离、抗真菌活性及对Talaromyces marneffei的作用机制
Zhou Wang,Jianglin Yin,Meng Bai et al.
Zhou Wang et al.
Mangrove-derived actinomycetes represent a rich source of novel bioactive natural products in drug discovery. In this study, four new polyene macrolide antibiotics antifungalmycin B-E (1-4), along with seven known analogs (5-11), were isola...
Mutable Collagenous Tissue: A Concept Generator for Biomimetic Materials and Devices [0.03%]
可变的胶原组织：一种用于仿生材料和设备的概念生成器
M Daniela Candia Carnevali,Michela Sugni,Francesco Bonasoro et al.
M Daniela Candia Carnevali et al.
Echinoderms (starfish, sea-urchins and their close relations) possess a unique type of collagenous tissue that is innervated by the motor nervous system and whose mechanical properties, such as tensile strength and elastic stiffness, can be...
Taxonomic, Phylogenomic and Bioactivity Profiling of Novel Phycosphere Bacterium from Model Cyanobacterium Synechococcus elongatus PCC 7942 [0.03%]
来自模式蓝藻Synechococcus elongatus PCC 7942的新型藻圈细菌的分类、系统基因组学和生物活性谱分析
Xiaoling Zhang,Jiaquan Xu,Jun Dai et al.
Xiaoling Zhang et al.
Phycosphere niches host rich microbial consortia that harbor dynamic algae-bacteria interactions with fundamental significance in varied natural ecosystems. Hence, culturing the uncultured microbial majority of the phycosphere microbiota is...
Bioprospection of the Antarctic Diatoms Craspedostauros ineffabilis IMA082A and Craspedostauros zucchelli IMA088A [0.03%]
南极迪式盘藻和Zucchelli迪式盘藻的生物探索
Riccardo Trentin,Emanuela Moschin,Luísa Custódio et al.
Riccardo Trentin et al.
In extreme environments such as Antarctica, a diverse range of organisms, including diatoms, serve as essential reservoirs of distinctive bioactive compounds with significant implications in pharmaceutical, cosmeceutical, nutraceutical, and...
Structural and Dynamical Basis of VP35-RBD Inhibition by Marine Fungi Compounds to Combat Marburg Virus Infection [0.03%]
海洋真菌化合物通过抑制VP35-RBD来对抗马尔堡病毒的结构和动力学基础
Abdullah S Alawam,Hadil Sultan Alawam,Mohammed Merae Alshahrani et al.
Abdullah S Alawam et al.
The Marburg virus (MBV), a deadly pathogen, poses a serious threat to world health due to the lack of effective treatments, calling for an immediate search for targeted and efficient treatments. In this study, we focused on compounds origin...
Semisynthesis and Cytotoxic Evaluation of an Ether Analogue Library Based on a Polyhalogenated Diphenyl Ether Scaffold Isolated from a Lamellodysidea Sponge [0.03%]
基于从Lamellodysidea海绵中分离的多卤二苯醚支架的醚类似物库的半合成及其细胞毒性评价
Kelsey S Ramage,Aaron Lock,Jonathan M White et al.
Kelsey S Ramage et al.
The known oxygenated polyhalogenated diphenyl ether, 2-(2',4'-dibromophenoxy)-3,5-dibromophenol (1), with previously reported activity in multiple cytotoxicity assays was isolated from the sponge Lamellodysidea sp. and proved to be an amena...
Deciphering the Glycosylation Steps in the Biosynthesis of P-1894B and Grincamycin Isolated from Marine-Derived Streptomyces lusitanus SCSIO LR32 [0.03%]
来自海洋来源的链霉菌SCSIO LR32的P-1894B和Grincamycin生物合成中的糖基化步骤解析
Hongbo Huang,Yun Zhang,Yongxiang Song et al.
Hongbo Huang et al.
Recently, we re-isolated the glycosylated angucycline antibiotics P-1894B (1) and grincamycin (1') from the marine-derived Streptomyces lusitanus SCSIO LR32 as potent antitumor agents and identified their biosynthesis gene cluster gcn. Both...
Alexandrium spp.: From Toxicity to Potential Biotechnological Benefits [0.03%]
亚历山大藻属物种：从毒性到潜在的生物技术益处
Eleonora Montuori,Daniele De Luca,Antonella Penna et al.
Eleonora Montuori et al.
Many dinoflagellates of the genus Alexandrium are well known for being responsible for harmful algal blooms (HABs), producing potent toxins that cause damages to other marine organisms, aquaculture, fishery, tourism, as well as induce human...
Prospective Antiviral Effect of Ulva lactuca Aqueous Extract against COVID-19 Infection [0.03%]
Ulva lactuca水提取物对COVID-19感染的预期抗病毒效果
Reem Binsuwaidan,Thanaa A El-Masry,Mostafa El-Sheekh et al.
Reem Binsuwaidan et al.
Marine algal extracts exhibit a potent inhibitory effect against several enveloped and non-enveloped viruses. The infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has several adverse effects, including an increased ...