Bioinspired Antimicrobial Strategy: An Extremophile Deep Sea Peptide to Combat Cystic Fibrosis Infections Caused by Pseudomonas aeruginosa and Staphylococcus aureus [0.03%]
受生物启发的抗菌策略：一种极地深海肽类化合物对抗由绿脓杆菌和金黄色葡萄球菌引起的囊性纤维化感染
Céline Boidin-Wichlacz,Marc Maresca,Teddy Grandjean et al.
Céline Boidin-Wichlacz et al.
Cystic fibrosis (CF)-associated lung infections caused by Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus) remain difficult to treat due to multidrug resistance and the redox instability of the pulmonary environm...
Mixotrophic Cultivation of Limnospira (Spirulina) platensis Using Early-Stage Fig Processing Wastewater: Effects on Biomass Composition, Antioxidants and Phycocyanin [0.03%]
利用早期发酵废液进行鱼腥藻混合营养培养：对生物量组成、抗氧化剂和藻蓝蛋白的影响
Luca Franzoso,Luca Usai,Riccardo Allodi et al.
Luca Franzoso et al.
The valorization of agro-industrial waste streams represents a promising strategy for reducing production costs in microalgae biotechnology while promoting circular economy approaches. In this study, wastewater derived from fig jam processi...
Development of HPMC-Based Hard Capsules with Rapid Disintegration Across Simulated Gastrointestinal pH Conditions: Formulation Design, Process Optimization, and Disintegration Mechanism of the HPMC/GG/ι-C Ternary System [0.03%]
基于羟丙基甲基纤维素的快速崩解胶囊的设计、优化及跨胃肠pH环境的快速崩解机制研究
Yuting Dong,Songlin Ye,Xiaojun Hong et al.
Yuting Dong et al.
While hydroxypropyl methylcellulose (HPMC) is a promising plant-based alternative to gelatin, its industrial application is limited by poor mechanical properties and high production costs. In this study, high-performance HPMC-based hard cap...
Mycosporine-like Amino Acids Biosynthesis in Asterarcys sp. Driving by Phosphorus Limitation: Evidence from Physiological and Transcriptomic Analyses [0.03%]
磷限制下Asterarcys sp.中麦孢素类似氨基酸的生物合成：生理和转录组分析提供的证据
Liang Wei,Hualian Wu,Jiayi Wu et al.
Liang Wei et al.
Mycosporine-like amino acids (MAAs), a class of secondary metabolites characterized by a cyclohexenone or cyclohexenimine ring structure bound to amino acid residues, are widely distributed in algae. These compounds exhibit strong ultraviol...
Schoenoplectus californicus (C.A. Mey.) Soják: Chemical Profile, Antioxidant Capacity, Psychopharmacological Exploration and Analgesic Activity [0.03%]
Schoenoplectus californicus(C.A. Mey.) Soják：化学特征、抗氧化能力、心理药理学探索和镇痛作用
Julio Campos-Florián,Gladys Galliani-Huamanchumo,Alessandra Victoria Campos-Bazán et al.
Julio Campos-Florián et al.
Schoenoplectus californicus, a macrophyte from Peruvian marine-coastal wetlands, is traditionally used for medicinal purposes, yet its pharmacological potential remains insufficiently explored. This study evaluated the chemical profile, ant...
Structural Characterization of an α-D-glucan from Bellamya purificata and Its Protective Effects on Non-Alcoholic Fatty Liver Disease in Zebrafish [0.03%]
来源于铜锈环棱螺的α-D-葡萄糖聚合物的结构表征及其对斑马鱼非酒精性脂肪肝病的保护作用
Xianhui Pan,Kangqi Zhou,Yuan Meng et al.
Xianhui Pan et al.
Non-alcoholic fatty liver disease (NAFLD) is a primary metabolic disorder that threatens adolescent health globally, with no effective therapeutic agents currently available. Bellamya purificata is a traditional Chinese medicine categorized...
Identification of Antioxidant and Anti-Inflammatory Activity of Sea Cucumber (Holothuria tubulosa) Active Peptides by a Combined Approach of Omics Data and Bioinformatics Analysis [0.03%]
基于组学数据和生物信息学分析的海参(Holothuria tubulosa)活性多肽抗氧化抗炎作用识别研究
Laura La Paglia,Mirella Vazzana,Manuela Mauro et al.
Laura La Paglia et al.
Background: Inflammatory signaling and oxidative stress machinery are interconnected and play roles in apoptosis, proliferation, redox state control, and the progression of many diseases, including cancer. The marine envi...
Thiol-Associated Antioxidant Activity of Recombinant Mussel Foot Protein Mfp6-1 Supports Cutaneous Wound Repair in a Murine Model [0.03%]
重组型软体动物足蛋白MFP6-1的硫醇类抗氧化活性可支持其在鼠模型中的皮肤伤口修复作用
Zi-Jun Li,Kun-Cheng Wang,Zhi-Ming Shen et al.
Zi-Jun Li et al.
Mussel foot proteins (Mfps) are renowned for their underwater adhesion, whereas their biotechnological potential for cutaneous wound repair remains largely underexplored. In this study, we identified and characterized a cysteine-rich mussel...
Diatomaceous Earth-Enabled Resveratrol Microemulsion for Enhanced Permeation and Stability [0.03%]
基于硅藻土的白藜芦醇微乳剂用于透皮吸收及稳定性的改善研究
Yotsanan Weerapol,Suwisit Manmuan,Somnathtai Yammen et al.
Yotsanan Weerapol et al.
This study developed a microemulsion system based on diatomaceous earth (DE) for the topical delivery of resveratrol. The microemulsions were prepared using pseudo-ternary phase diagrams. A 4:1 ethanol:virgin coconut oil ratio resulted in a...
Marine Antimicrobial Peptide as a Promising Alternative to Polymyxin B [0.03%]
海洋抗微生物肽作为多粘菌素B的 promising 替代品
Victoria N Safronova,Vladislav A Lushpa,Victoria O Shipunova et al.
Victoria N Safronova et al.
The rise in antimicrobial resistance represents a significant challenge to global health. The reason partially lies in an inappropriate use of conventional antibiotics and the subsequent rapid spread of multidrug-resistant pathogen strains....