Neuroprotective and Therapeutic Effects of Tocovid and Twendee-X on Aβ Oligomer-Induced Damage in the SH-SY5Y Cell Line [0.03%]
他科维生素和Twendee-X对Aβ寡聚体诱导的SH-SY5Y细胞损伤的神经保护及治疗作用
Xiao Hu,Toru Yamashita,Haibo Yu et al.
Xiao Hu et al.
Background: Alzheimer's disease (AD) is the most frequent cause of dementia among the elderly. The accumulation of amyloid beta (Aβ) and its downstream pathological events such as oxidative stress play central roles in A...
Inflammatory Cytokine Levels in Patients with Sporadic Amyotrophic Lateral Sclerosis [0.03%]
散发性肌萎缩侧索硬化患者的炎症细胞因子水平分析
Qionghua Sun,Yunyun Huo,Jiongming Bai et al.
Qionghua Sun et al.
Objectives: In the present study, inflammatory factors, including interleukin (IL) and tumor necrosis factor-α (TNF-α) in the peripheral blood of patients with sporadic amyotrophic lateral sclerosis (sALS), were evaluat...
Sexuality and Neurodegenerative Disease: An Unmet Challenge for Patients, Caregivers, and Treatment [0.03%]
神经退行性疾病患者的性生活：患者、照料者和治疗医生面临的挑战
Mohamed Eshmawey
Mohamed Eshmawey
Background: Many factors affect sexuality in the elderly such as dementia which is a common cause of inappropriate sexual behaviors. These behavioral disturbances are distressing, disruptive, and impair the care of the pa...
Homoharringtonine Inhibits Alzheimer's Disease Progression by Reducing Neuroinflammation via STAT3 Signaling in APP/PS1 Mice [0.03%]
同哈灵顿碱通过STAT3信号减少神经炎症来抑制APP/PS1小鼠阿尔茨海默病的进展
Xinyuan Jiang,Qingdong Wu,Cuicui Zhang et al.
Xinyuan Jiang et al.
Background: Accumulating evidence suggests an implication of neuroinflammation in Alzheimer's disease (AD) pathogenesis. Homoharringtonine (HHT) is an antitumor reagent with anti-inflammatory activity. This study investig...
Increased Intake of Fast-Acting Carbohydrates in Patients with Parkinson's Disease [0.03%]
帕金森病患者对快速起效碳水化合物摄入量的增加
Eva Schaeffer,Alina Schermann,Florian Zirbs et al.
Eva Schaeffer et al.
Background: Patients with Parkinson's disease (PD) regularly report an increased desire for food or beverages with high sugar content. Objective: ...
Heart Rate Variability during Wake and Sleep in Huntington's Disease Patients: An Observational, Cross-Sectional, Cohort Study [0.03%]
亨廷顿病患者在白天和睡眠中的心率变异性：一项观察性、横断面队列研究
Jessica Marotta,Carla Piano,Valerio Brunetti et al.
Jessica Marotta et al.
Introduction: Autonomic dysfunction has been reported as one of nonmotor manifestations of both presymptomatic and manifest Huntington's disease (HD). The aim of our study was to evaluate heart rate variability (HRV) duri...
Observational Study
Neuro-degenerative diseases. 2021;21(3-4):79-86. DOI:10.1159/000520754 2021
Review of Available Data for the Efficacy and Effectiveness of Nabiximols Oromucosal Spray (Sativex®) in Multiple Sclerosis Patients with Moderate to Severe Spasticity [0.03%]
纳比希蒙口腔喷雾剂(Sativex®)对中重度肌强直的多发性硬化症患者疗效和效果已有数据综述
Antonella Conte,Carlos Vila Silván
Antonella Conte
Background: Sativex (USAN: nabiximols [NAB]) oromucosal spray is indicated for treatment of multiple sclerosis (MS) patients with moderate to severe spasticity and inadequate response to other antispasticity medications w...
Beatrice Heim,Marina Peball,Carsten Saft et al.
Beatrice Heim et al.
Objective: We aimed to investigate costly punishment in patients with Huntington's disease (HD). Background: HD is an autosomal dominan...
Cerebrospinal Fluid Levels of 5-Hydroxyindoleacetic Acid in Parkinson's Disease and Atypical Parkinsonian Syndromes [0.03%]
帕金森病及非典型帕金森综合症的脑脊液5-羟基吲哚乙酸水平研究
Michaela Kaiserova,Monika Chudackova,Hana Prikrylova Vranova et al.
Michaela Kaiserova et al.
Background: Various cerebrospinal fluid (CSF) biomarkers are studied in Parkinson's disease (PD) and atypical parkinsonian syndromes (APS). Several studies found reduced 5-hydroxyindoleacetic acid (5-HIAA), the main serot...
Irene Rosas,Germán Morís,Eliecer Coto et al.
Irene Rosas et al.
Background: Many evidences suggest a pathological link between neurodegenerative diseases and cancer. In fact, several epidemiologic studies indicate a decreased incidence of most cancer types in Parkinson's disease (PD) ...