Autophagy in Alzheimer's disease: mechanisms, clinical trials, and horizons [0.03%]
阿尔茨海默病的自噬：机制、临床试验和前景
Tshibambe N Tshimbombu,Kyle E Thurmann,Boris Decourt et al.
Tshibambe N Tshimbombu et al.
Background: Alzheimer's disease (AD) is an incurable progressive neurodegenerative disorder characterized by the pathological accumulation of amyloid beta (Aβ) plaques and neurofibrillary tangles in the brain. Recent fin...
Spinocerebellar Ataxia Type 12: Spectrums of Movement Disorders and Clinical Features [0.03%]
脊小脑萎缩症型12的运动障碍及临床特征分析
Mohammad Ali Rafiei,Sara Sadeghzadeh,Mehri Salari et al.
Mohammad Ali Rafiei et al.
Background: Spinocerebellar ataxia type 12 (SCA12) is a neurodegenerative disorder caused by a CAG repeat expansion in the PPP2R2B gene. It is characterized by tremor, cerebellar ataxia, and a wide range of neurological s...
Standardising normal pressure hydrocephalus diagnosis: the interdisciplinary Lausanne's protocol [0.03%]
正常压力性脑积水诊断的标准化：洛桑多学科协议
Eric Morel,Jenny C Kienzler,Giulia Bommarito et al.
Eric Morel et al.
Introduction: Idiopathic normal pressure hydrocephalus (iNPH) is a reversible neurological condition characterized by gait disorders, cognitive impairment and urinary incontinence with ventriculomegaly at brain imaging. D...
Just Semantics? How Diagnostic Criteria Influence Physician-Patient Narratives in Alzheimer's Disease [0.03%]
仅仅是语义问题吗？诊断标准如何影响阿尔茨海默病的医患叙述？
Alice Accorroni,Christine Clavien,Giovanni B Frisoni
Alice Accorroni
Introduction: The current diagnosis of Alzheimer's disease (AD) is shaped by the Alzheimer's Association (AA) and the International Working Group (IWG) criteria. While both frameworks lead to similar physician-patient con...
Hearing Loss as a Potentially Modifiable Marker of Dementia Risk: Neurological Evidence, Uncertainty, and Clinical Interpretation [0.03%]
听力损失作为痴呆风险的潜在可改变标志物：神经学证据、不确定性及临床解读
Verónica Fuentes-Santamaría,Carmen María Díaz García,Juan Carlos Alvarado
Verónica Fuentes-Santamaría
Hearing impairment has emerged as a consistently associated and potentially modifiable risk factor for cognitive decline and dementia, including Alzheimer's disease (AD). Epidemiological studies demonstrate an increased dementia risk among ...
Predictors of Incident Dementia in a Cohort of Elders with Essential Tremor: A Prospective, Longitudinal Study [0.03%]
老年原发性震颤人群中痴呆发生的预测因素：一项前瞻性研究
Diane S Berry,Stephanie Cosentino,Elan D Louis
Diane S Berry
Background: Elders with essential tremor (ET) are at a heightened risk for incident dementia. Although the consequences of this diagnosis are formidable, we know little about what factors elevate the risk of ET-dementia. ...
Cognitive impairment is associated with disrupted motor planning in older adults [0.03%]
认知障碍与老年人运动计划的紊乱有关
Gabriel Poirier,Charalambos Papaxanthis,Lucie Lordon et al.
Gabriel Poirier et al.
Background: Neurocognitive disorders are frequently accompanied by motor impairments that may precede overt cognitive decline. However, most motor markers remain coarse and do not disentangle global motor deterioration fr...
Beyond the Leak: Advanced MRI Assessment of the Blood-Brain Barrier in Neurodegeneration [0.03%]
超越泄漏：神经退行性疾病的血脑屏障高级MRI评估
Daniele Botta,Caterina Bernetti,Ioana Hutuca et al.
Daniele Botta et al.
The blood-brain barrier (BBB) is a specialized multicellular interface that maintains the CNS's tightly regulated microenvironment. BBB disruption is increasingly recognized as a key feature of neurodegeneration, documented across disorders...
The utility of Speech and Language analytics for screening Alzheimer's Disease [0.03%]
语音和语言分析在阿尔茨海默病筛查中的应用价值
Alveena Siddiqui,Thayabaran Kathiresan,Mark Opler et al.
Alveena Siddiqui et al.
Background: Effective screening and cohort enrichment remain major challenges in clinical trials for Alzheimer's disease (AD), where traditional diagnostic pathways rely on costly, invasive, and time-consuming procedures....
Facial Emotion Recognition Deficits and EEG Alterations in Mild Behavioral Impairment [0.03%]
轻度行为障碍患者的面部情绪识别缺陷和脑电图改变
YongSoo Shim,Eun-Ye Lim
YongSoo Shim
Background: Mild Behavioral Impairment (MBI) is a late-life neurobehavioral syndrome associated with increased risk of incident cognitive decline and dementia. Facial emotion recognition (FER), a core component of social ...