Frontostriatal Circuits Alterations Associated with Cognitive Flexibility Deterioration in Huntington's Disease [0.03%]
亨廷顿舞蹈病认知灵活性减退相关的前额皮层-纹状体环路改变
Gustavo Padron-Rivera,Angel Omar Romero-Molina,Rosalinda Diaz et al.
Gustavo Padron-Rivera et al.
Background: Recent resting-state functional magnetic resonance imaging studies have reported abnormal functional connectivity (FC) in the prefrontal cortex (PFC)-striatum circuit in patients with premanifest Huntington's ...
Landis E Llewelyn,Myriam Kornisch,Hyejin Park et al.
Landis E Llewelyn et al.
Background: While the hippocampus is not part of the nigrostriatal dopaminergic pathway, influence of Parkinson's disease (PD) on the hippocampus has been consistently implicated. However, it is not clear how the hippocam...
Synaptic Neurofilaments and GluN1-Neurofilament Light Chain Interaction in Experimental Models of α-Synucleinopathies [0.03%]
α-突触核蛋白病实验模型中的突触神经丝和GluN1-神经丝轻链相互作用
Alberto Imarisio,Elena Ferrari,Andrea Pilotto et al.
Alberto Imarisio et al.
Introduction: Although neurofilaments are mainly expressed in large caliber myelinated axons, recent evidence supports the existence of a specific synaptic pool, where neurofilament light chain (NfL) has been proposed to ...
Clinical and Molecular Findings of Intermediate Allele Carriers in the HTT Gene from the Mexican Mestizo Population [0.03%]
墨西哥混血人种人群HTT基因中间等位基因携带者的临床和分子特征
Miguel Ángel Ramírez-García,David José Dávila-Ortiz de Montellano,Leticia Martínez-Ruano et al.
Miguel Ángel Ramírez-García et al.
Introduction: There are reports of different clinical statuses in carriers of intermediate alleles (IAs) of CAG trinucleotide repeats in the HTT gene, from individuals affected by a clinical picture indistinguishable from...
Early Autonomic Symptoms Predict Functional Decline in Parkinson's Disease Independent of Dopaminergic Therapy [0.03%]
早期自主神经症状可独立于多巴胺能治疗预测帕金森病功能衰退
Cameron Miller-Patterson,Jesse Y Hsu,Lana M Chahine
Cameron Miller-Patterson
Introduction: Parkinson's disease (PD) has variable progression; identifying determinants of functional decline in PD is needed for accurate prognostication. Autonomic symptoms can result from dopaminergic therapy but may...
Heart Rate Variability in Huntington Disease: A Long-Term Longitudinal Study [0.03%]
亨廷顿舞蹈病患者的心率变异性长期纵向研究
Jan Kobal,Ksenija Cankar,Ziva Melik
Jan Kobal
Introduction: The aim of the study was to follow tonic and phasic autonomic nervous activity in Huntington disease (HD) mutation carriers and patients. Me...
Observational Study
Neuro-degenerative diseases. 2022;22(1):1-6. DOI:10.1159/000525415 2022
Juvenile-Onset Kufs Disease in a Chinese Consanguineous Family due to CLN6 Mutation [0.03%]
CLN6突变导致的中国近亲结婚家庭中的早发性Kufs病
Weimin Jia,Yalin Luo,Jiuxiang Wang et al.
Weimin Jia et al.
Objective: The aim of this study was to identify the genetic cause of two cases of Kufs disease in the same family. The two affected individuals exhibited different levels of severity under magnetic resonance imaging (MRI...
Diagnostic Accuracy of Noun- and Verb-Naming Tasks in Detecting Cognitive Impairment in Parkinson's Disease [0.03%]
名词和动词命名任务在帕金森病认知障碍检测中的诊断准确性
Edoardo Nicolò Aiello,Margherita Grosso,Claudia Caracciolo et al.
Edoardo Nicolò Aiello et al.
Background: In Parkinson's disease (PD), verb-naming tasks (VNTs) have been proposed as superior to noun-naming ones in detecting language deficits, although such a hypothesis is not supported at a statistical level. ...
Distribution Changes of Neural Precursor Cells in the Brain Stem of Tg(SOD1*G93A)1Gur Mice [0.03%]
Tg(SOD1*G93A)1Gur小鼠脑干神经干细胞分布的变化
Xiaoping Shen,Chunyan Tang,Qin Kang et al.
Xiaoping Shen et al.
Objectives: The alteration of vimentin-containing cells (VCCs) proliferation, differentiation, and migration in the brain stem of amyotrophic lateral sclerosis (ALS)-like transgenic mice (Tg(SOD1*G93A)1Gur mice) (TG mice)...
Plasma Cystatin C Correlates with Plasma NfL Levels and Predicts Disease Progression in Parkinson's Disease [0.03%]
血浆半胱氨酸蛋白酶抑制剂C与血浆神经丝轻链水平相关，并可预测帕金森病进展
Alberto Imarisio,Andrea Pilotto,Emirena Garrafa et al.
Alberto Imarisio et al.
Introduction: Previous studies reported increased plasma levels of cystatin C (Cys-C) in Parkinson's disease (PD) and claimed for a possible association with disease severity and progression. The aim of this study was to ...