Primary cilia and signaling pathways in mammalian development, health and disease [0.03%]
原纤毛与信号转导通路在哺乳动物发育、健康及疾病中的作用
Iben R Veland,Aashir Awan,Lotte B Pedersen et al.
Iben R Veland et al.
Although first described as early as 1898 and long considered a vestigial organelle of little functional importance, the primary cilium has become one of the hottest research topics in modern cell biology and physiology. Primary cilia are n...
Adenosine A(1) receptors determine glomerular hyperfiltration and the salt paradox in early streptozotocin diabetes mellitus [0.03%]
腺苷A1受体决定早期链脲佐菌素糖尿病的肾小球高滤过及盐度悖论
Volker Vallon,Jana Schroth,Joseph Satriano et al.
Volker Vallon et al.
Background: In early type 1 diabetes mellitus, changes in proximal reabsorption influence glomerular filtration rate (GFR) through tubuloglomerular feedback (TGF). Due to TGF, a primary increase in proximal reabsorption c...
Altered renal expression of Na(+) transporters and ROMK in protein-deprived rats [0.03%]
蛋白质剥夺大鼠肾Na+转运蛋白和ROMK表达的改变
María Celeste Ruete,Liliana C Carrizo,María Victoria Bocanegra et al.
María Celeste Ruete et al.
Potassium depletion has been associated with altered sodium reabsorption in tubule segments. We studied if the altered abundance of Na(+) transporters and ROMK are associated with distal potassium secretion that contributes to the developme...
Histochemical detection of ischemia-like alterations induced in kidney tissue in vitro--different sensitivity to oxidant stress of glomerular ENTPD1 versus E5NT [0.03%]
肾缺血样改变的组化检测及肾小球ENTPD1与E5NT氧化应激反应差异性研究
Alexander P J Vlaar,Willem J van Son,Winston W Bakker
Alexander P J Vlaar
The expression of ENTPD1 (ecto-nucleoside triphosphate diphosphohydrolase) along the glomerular microvasculature of the kidney is downregulated in ischemic conditions, in contrast to E5NT (ecto-5'-nucleotidase), which may explain the increa...
Peter Y Chuang,John C He
Peter Y Chuang
The kidney podocyte is a terminally differentiated and highly specialized cell. The function of the glomerular filtration barrier depends on the integrity of the podocyte. Podocyte injury and loss have been observed in human and experimenta...
The alternatively spliced anti-angiogenic family of VEGF isoforms VEGFxxxb in human kidney development [0.03%]
人肾脏发育中血管内皮生长因子VEGFxxxb亚型家族的可选择性剪辑及抗血管生成作用研究
Heather S Bevan,Nynke M S van den Akker,Yan Qiu et al.
Heather S Bevan et al.
Background/aim: Vascular endothelial growth factor (VEGF), required for renal development, is generated by alternative splicing of 8 exons to produce two families, pro-angiogenic VEGF(xxx), formed by proximal splicing in ...
Time course of organic anion excretion in rats with bilateral ureteral obstruction: role of organic anion transporters (Oat1 and Oat3) [0.03%]
大鼠双侧输尿管梗阻时有机阴离子排泄的动态变化及其对有机阴离子转运蛋白（Oat1和Oat3）的作用
Silvina R Villar,Anabel Brandoni,Adriana M Torres
Silvina R Villar
Background: Urinary tract obstruction is a common cause of renal failure. In this study, we evaluated the time course of P-aminohippurate (PAH) renal excretion and the cortical expression of organic anion transporters (Oa...
Mechanism of Cd-induced inhibition of Na-glucose cotransporter in rabbit proximal tubule cells: roles of luminal pH and membrane-bound carbonic anhydrase [0.03%]
镉通过管腔pH和膜结合碳酸酐酶抑制兔近端肾小管Na-葡萄糖同向转运机制的作用
Shuichi Tsuruoka,Erik R Swenson,Akio Fujimura et al.
Shuichi Tsuruoka et al.
Background/aims: We have previously reported that a complex of cadmium-metallothionein (Cd-MT) directly affects the apical Na-glucose cotransporter on the luminal side in proximal tubules, suggesting that Cd-MT is more to...
Josée Bouchard,Nitin Khosla,Ravindra L Mehta
Josée Bouchard
Dialytic therapies have undergone major technological developments in the last decade and emerging techniques are promoted not only for acute kidney injury, but also for sepsis, acute decompensated heart failure, and acute and acute-on-chro...
Carolyn M Feltes,Jennifer Van Eyk,Hamid Rabb
Carolyn M Feltes
Acute kidney injury (AKI) contributes significantly to morbidity and mortality in both adults and children. While clinical data suggest that AKI contributes to and exacerbates multiorgan failure, the physiologic and molecular mechanisms res...