Are sodium transporters in urinary exosomes reliable markers of tubular sodium reabsorption in hypertensive patients? [0.03%]
尿液外泌体中的钠转运蛋白可作为高血压患者肾小管重吸收标志物吗？
Cristina Esteva-Font,Xiaoyan Wang,Elisabet Ars et al.
Cristina Esteva-Font et al.
Background: Altered renal sodium handling has a major pathogenic role in salt-sensitive hypertension. Renal sodium transporters are present in urinary exosomes. We hypothesized that sodium transporters would be excreted i...
Distal renal tubular acidosis in Filipino children, caused by mutations of the anion-exchanger SLC4A1 (AE1, Band 3) gene [0.03%]
菲儿童远端肾小管性酸中毒由带3基因(SLCA4A1或AE1)突变引起
Francisco E Anacleto,Lesley J Bruce,Peter Clayton et al.
Francisco E Anacleto et al.
Aim: To describe the clinical features and genetic basis of distal renal tubular acidosis (dRTA) in Filipino children. Methods: Clinica...
Vasopressin type 2 receptor V88M mutation: molecular basis of partial and complete nephrogenic diabetes insipidus [0.03%]
血管加压素2型受体V88M突变：部分性及完全性肾性尿崩症的分子发病基础
Detlef Bockenhauer,Eric Carpentier,Driss Rochdi et al.
Detlef Bockenhauer et al.
Background/aims: Mutations in the type 2 vasopressin receptor gene (AVPR2) underlie X-linked recessive nephrogenic diabetes insipidus (NDI). Here, we report on a family with a mutation in AVPR2, c.262G>A (p.V88M). This re...
Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice [0.03%]
肾近曲小管转运增强参与了Cyp4a14敲除小鼠高血压发病机制
Raymond Quigley,Sumana Chakravarty,Xueying Zhao et al.
Raymond Quigley et al.
Background/aims: Disrupting the enzyme Cyp4a14 in mice leads to hypertension, which is more severe in the male mice and appears to be due to androgen excess. Because the Cyp4a14 enzyme is located in the proximal tubule of...
Sympathetic nerve varicosities in close apposition to basolateral membranes of collecting duct epithelial cells of rat kidney [0.03%]
肾交感神经血管球与集合管上皮细胞基侧膜相邻接近分布
Andrzej Loesch,Robert Unwin,Vanita Gandhi et al.
Andrzej Loesch et al.
Background: There are reports of sympathetic innervation of the nephron and of P2 purinergic receptors on epithelial cells. Since ATP is a cotransmitter with noradrenaline in sympathetic nerves, the objective of the prese...
PGE2 causes mesangial cell hypertrophy and decreases expression of cyclin D3 [0.03%]
PGE2引起系膜细胞肥大并降低cyclin D3的表达量
Qian Qian,Kamal M Kassem,William H Beierwaltes et al.
Qian Qian et al.
Background/aims: Glomerular hypertrophy is a feature of many glomerular diseases and is associated with the development of renal failure. We previously demonstrated that the cyclooxygenase 2 inhibitor, NS398, reduced glom...
An inner medullary concentrating process actuated by renal pelvic/calyceal muscle contractions: assessment and hypothesis [0.03%]
由肾盂/肾盏平滑肌收缩激活的髓质浓缩机制：评估与假设
G G Pinter,J L Shohet
G G Pinter
We propose a mechanism of an inner medullary concentrating process in which water extraction is accomplished by a colloid osmotic mechanism and hydrostatic pressure. There are 3 essential features of the proposal: 1. the fluid compartmental...
Mutational analysis of CLC-5, cofilin and CLC-4 in patients with Dent's disease [0.03%]
Dent病患者CLC-5、cofilin和CLC-4的突变分析
Fiona Wu,Anita A C Reed,Sian E Williams et al.
Fiona Wu et al.
Background/aims: Dent's disease is caused by mutations in the chloride/proton antiporter, CLC-5, or oculo-cerebro-renal-syndrome-of-Lowe (OCRL1) genes. Me...