Fluid shear stress induces renal epithelial gene expression through polycystin-2-dependent trafficking of extracellular regulated kinase [0.03%]
流体剪切应力通过多囊肿蛋白-2依赖性胞外调节激酶易位诱导肾上皮基因表达
Daniel Flores,Lorenzo Battini,G Luca Gusella et al.
Daniel Flores et al.
Background: The cilium and cilial proteins have emerged as principal mechanosensors of renal epithelial cells responsible for translating mechanical forces into intracellular signals. Polycystin-2 (PC-2), a cilial protein...
Nikola Jeck,Hannsjörg W Seyberth
Nikola Jeck
Great progress has been made in the last 15 years in the characterization and the pathophysiological understanding of renal salt and water wasting associated with inherited disorders of the thick ascending limb (TAL) of Henle's loop, the lo...
Renal stone disease [0.03%]
肾结石疾病
John A Sayer
John A Sayer
Background/aims: Renal stone disease may be seen as a clinical symptom of an underlying pathological process predisposing to crystallization within the renal tract. Renal stones may be comprised of calcium salts, uric aci...
Fiona E Karet
Fiona E Karet
Disorders of water balance lead either to dehydration or overhydration. Because there is an intimate relationship between water and sodium concentration (water generally following salt), one can distinguish hypotonic, isotonic and hypertoni...
Disorders of calcium metabolism [0.03%]
钙代谢紊乱
John F O&#x;Toole
John F O&#x;Toole
The genetic contribution to calcium metabolism is well recognized. Many of the proteins that contribute to calcium homeostasis through intestinal absorption, bone deposition and resorption, renal reabsorption and the molecules regulating th...
R Tyler Miller
R Tyler Miller
The distal convoluted tubule (DCT) reabsorbs 5-10% of filtered Na, and is an important site for regulation of Na balance. Additionally, the amount and composition of the tubular fluid that leaves the DCT affects H and K secretion in more di...
Arend Bökenkamp,Michael Ludwig
Arend Bökenkamp
Following glomerular filtration, the bulk of solutes are reabsorbed in the proximal tubule to prevent excessive losses of vital metabolites. In this nephron segment, reabsorption is largely active via dedicated transporters. Hereditary defe...
Selective blockade of oxytocin and vasopressin V(1a) receptors in anaesthetised rats: evidence that activation of oxytocin receptors rather than V(1a) receptors increases sodium excretion [0.03%]
选择性阻断大鼠血管加压素和缩宫素V(1a)受体：缩宫素受体的激活比V(1a)受体更可增加钠排泄的证据
D G Shirley,M F Walter,B D Keeler et al.
D G Shirley et al.
Background: Although it is known that moderate-to-high doses of the neurohypophysial hormones oxytocin and vasopressin are natriuretic, doubts remain over the identity of the receptors responsible. To address this issue, ...
Transient receptor potential melastatin 6 knockout mice are lethal whereas heterozygous deletion results in mild hypomagnesemia [0.03%]
TRPM6敲除小鼠致死而杂合子缺失导致轻度低镁血症
Titia E Woudenberg-Vrenken,Arjaree Sukinta,Annemiete W van der Kemp et al.
Titia E Woudenberg-Vrenken et al.
Background: Hypomagnesemia with secondary hypocalcemia is due to disturbed renal and intestinal magnesium (Mg(2+)) (re)absorption. The underlying defect is a mutation in the transient receptor potential melastatin type 6 ...
P P Sainaghi,L Bergamasco,L Castello et al.
P P Sainaghi et al.
Background and aims: The presence of altered plasma Na concentration (PNa) allows calculations of changes in water and electrolyte contents, which are not feasible during normonatremic derangements. We have developed a co...