Aging and physiological changes of the kidneys including changes in glomerular filtration rate [0.03%]
肾脏老化及生理变化包括肾小球滤过率的变化
Carlos G Musso,Dimitrios G Oreopoulos
Carlos G Musso
In addition to the structural changes in the kidney associated with aging, physiological changes in renal function are also found in older adults, such as decreased glomerular filtration rate, vascular dysautonomia, altered tubular handling...
Potential role of serine proteases in modulating renal sodium transport in vivo [0.03%]
关于蛋白酶在调节体内肾钠转运中的潜在作用
G Jacquillet,I Rubera,R J Unwin
G Jacquillet
The maintenance of sodium (Na+) homeostasis is an essential function of the kidney. It is achieved by a variety of transport processes localized all along the highly specialised segments of the nephron. Impairment of these transport mechani...
Hypertonic stress promotes the upregulation and phosphorylation of zonula occludens 1 [0.03%]
hypertonic应激通过促进zonula occludens 1的上调及其磷酸化作用增强细胞间连接屏障功能
Cornelia Then,Tobias Bergler,Roland Jeblick et al.
Cornelia Then et al.
Tight junction molecules form a barrier between adjacent cells and mediate the cells' ability to develop membranes that constitute boundaries of different compartments within the body. Membranes with selective ion and water passage are impo...
Proteomic approaches in understanding a detected relationship between chemotherapy-induced nephrotoxicity and cell respiration in HK-2 cells [0.03%]
质谱技术在研究化疗药物肾毒性和细胞呼吸关系中的应用
Juliana Dinéia Perez,Juliana Almada Colucci,Maísa Mayumi Sakata et al.
Juliana Dinéia Perez et al.
Background/aims: Nephrotoxicity is a prominent component of the profile of chemotherapeutic agents and to date proteomics has represented the main technique to identify protein profiles in response to xenobiotic exposure....
New evidence of a dihydropyridine-activated cationic channel in the MDCK cell line [0.03%]
新的证据表明在MDCK细胞系中激活cationic通道的作用因素是dihydropyridine
E Melendez,M Bidet,J L Reyes et al.
E Melendez et al.
Newborn rat distal cells express an apical Ca2+ channel activated by dihydropyridine drugs. Similarly, in Madin-Darby canine kidney (MDCK) cells, nifedipine increased Ca2+i in a concentration-dependent manner (IC50=4 μM) in fura-2-loaded c...
Comparative Study
Nephron. Physiology. 2011;118(4):p73-81. DOI:10.1159/000325467 2011
Ewout J Hoorn,Daphne Hotho,Robert Jan Hassing et al.
Ewout J Hoorn et al.
Background: Hyponatremia is a common diagnostic challenge. Methods: An index case is presented to discuss the diagnostic approach to ch...
Case Reports
Nephron. Physiology. 2011;118(3):p66-71. DOI:10.1159/000322240 2011
Amelogenesis imperfecta and nephrocalcinosis syndrome: a case report and review of the literature [0.03%]
牙本质发育不全和肾钙质沉着病综合征的病例报告及文献回顾
Hercílio Martelli-Júnior,Pedro Eleutério dos Santos Neto,Sibele Nascimento de Aquino et al.
Hercílio Martelli-Júnior et al.
Amelogenesis imperfecta (AI) is a group of hereditary disorders that affect the quality and/or quantity of dental enamel. This paper describes the clinicopathological features of a patient who was born of consanguineous parents and who pres...
Identification of a novel WNK4 mutation in Chinese patients with pseudohypoaldosteronism type II [0.03%]
伪低醛固酮症Ⅱ型患者WNK4的新突变识别
Chong Zhang,Zhaohui Wang,Jingyuan Xie et al.
Chong Zhang et al.
Background: It has been reported that mutations in WNK1 and WNK4 cause pseudohypoaldosteronism type II (PHA2), an autosomal dominant renal disease. WNK kinase proteins are expressed in the kidney and regulate ion transpor...
Hyponatremia and inflammation: the emerging role of interleukin-6 in osmoregulation [0.03%]
低钠血症与炎症：细胞因子白介素6在渗透调节中的作用不容忽视
Reinout M Swart,Ewout J Hoorn,Michiel G Betjes et al.
Reinout M Swart et al.
Although hyponatremia is a recognized complication of several inflammatory diseases, its pathophysiology in this setting has remained elusive until recently. A growing body of evidence now points to an important role for interleukin-6 in th...