Assessment of the effect of 24-hour aldosterone administration on protein abundance in fluorescence-sorted mouse distal renal tubules by mass spectrometry [0.03%]
基于质谱对氟光分选的小鼠远端肾小管蛋白丰度进行评价：醛固酮24小时给药的影响
Thomas B Jensen,Trairak Pisitkun,Jason D Hoffert et al.
Thomas B Jensen et al.
Background/aims: Aldosterone exerts multiple long-term effects on the distal renal tubules. The aim of this study was to establish a method for identifying proteins in these tubules that change in abundance by only 24-hou...
Response of the renal inner medulla to hypoxia: possible defense mechanisms [0.03%]
肾内髓对缺氧的反应：可能的防御机制
Namhee Kim,Laura Voicu,Gregory M T Hare et al.
Namhee Kim et al.
Background/aims: Owing to the precarious blood supply to the renal medulla and the high metabolic requirement of the medullary thick ascending limb of Henle's loop, this nephron segment should be especially vulnerable whe...
Extracellular pyrophosphate in the kidney: how does it get there and what does it do? [0.03%]
肾脏细胞外焦磷酸盐：它如何到达哪里以及它的功能是什么？
Shabbir H Moochhala
Shabbir H Moochhala
Pyrophosphate (PPi) is well known as a regulator of calcification, and the ANKH (ANK in mouse) protein has a role in the membrane transport of PPi. Earlier work concentrated on bones and joints, but ANKH is also likely to have important rol...
An intact kidney slice model to investigate vasa recta properties and function in situ [0.03%]
一种完整肾脏切片模型用于体内研究弓形血管的特性和功能
C Crawford,T Kennedy-Lydon,C Sprott et al.
C Crawford et al.
Background: Medullary blood flow is via vasa recta capillaries, which possess contractile pericytes. In vitro studies using isolated descending vasa recta show that pericytes can constrict/dilate descending vasa recta whe...
An acute infusion of lactic acid lowers the concentration of potassium in arterial plasma by inducing a shift of potassium into cells of the liver in fed rats [0.03%]
一次性的乳酸急性输入通过将钾离子转移到喂养大鼠肝脏中的细胞内来降低动脉血浆中钾的浓度
S Cheema-Dhadli,C-K Chong,K S Kamel et al.
S Cheema-Dhadli et al.
Background: Potassium (K(+)) input occurs after meals or during ischemic exercise and is accompanied by a high concentration of L-lactate in plasma (P(L-lactate)). ...
Electrolyte-free water clearance versus modified electrolyte-free water clearance: do the results justify the effort? [0.03%]
无电解质水清除率与改良的无电解质水清除率：结果值得付出更多努力吗？
Gregor Lindner,Christoph Schwarz
Gregor Lindner
Background: Calculation of electrolyte-free water clearance (EFWC) allows for quantification of renal losses of free water and was shown to be helpful in the differential diagnosis of dysnatremias and might help in the co...
Comparative Study
Nephron. Physiology. 2012;120(1):p1-5. DOI:10.1159/000336550 2012
Renal stone disease: a commentary on the nature and significance of Randall's plaque [0.03%]
肾结石病：Randall斑质的性质及意义述评
A P Evan,R J Unwin,J C Williams Jr
A P Evan
Bernard Freudenthal,Duvaraka Kulaveerasingam,Lokesh Lingappa et al.
Bernard Freudenthal et al.
Background/aims: Mutations in the inwardly-rectifying K+ channel KCNJ10/Kir4.1 cause an autosomal recessive disorder characterized by epilepsy, ataxia, sensorineural deafness and tubulopathy (EAST syndrome). KCNJ10 is exp...
Familial autosomal recessive renal tubular acidosis: importance of early diagnosis [0.03%]
家族性常染色体隐性遗传型肾小管酸中毒：早期诊断的重要性
Asaf Vivante,Danny Lotan,Naomi Pode-Shakked et al.
Asaf Vivante et al.
Background and aims: Untreated renal tubular acidosis (RTA) can result in severe complications. We reviewed the clinical features of patients with mutations in two genes causing RTA and evaluated their developmental expre...
Multicenter Study
Nephron. Physiology. 2011;119(3):p31-9. DOI:10.1159/000329668 2011
Senile nephrosclerosis--does it explain the decline in glomerular filtration rate with aging? [0.03%]
老年肾硬化症会随着年龄的增长导致肾小球滤过率下降吗？
Andrew D Rule,Lynn D Cornell,Emilio D Poggio
Andrew D Rule
Nephrosclerosis can be defined by the presence of glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis on renal biopsy. Chronic kidney disease is identified clinically by a reduction in glomerular filtration rate...