Bolus administration of intravenous glucose in the treatment of hyperkalemia: a randomized controlled trial [0.03%]
静脉注射葡萄糖治疗高钾血症的临床试验研究
Mogamat-Yazied Chothia,Mitchell L Halperin,Megan A Rensburg et al.
Mogamat-Yazied Chothia et al.
Background: Hyperkalemia is a common medical emergency that may result in serious cardiac arrhythmias. Standard therapy with insulin plus glucose reliably lowers the serum potassium concentration ([K(+)]) but carries the ...
Randomized Controlled Trial
Nephron. Physiology. 2014;126(1):1-8. DOI:10.1159/000358836 2014
Beyond linear methods of data analysis: time series analysis and its applications in renal research [0.03%]
超越线性数据统计方法——时间序列分析及其在肾脏病学中的应用
Ashwani K Gupta,Andreea Udrea
Ashwani K Gupta
Analysis of temporal trends in medicine is needed to understand normal physiology and to study the evolution of disease processes. It is also useful for monitoring response to drugs and interventions, and for accountability and tracking of ...
Katharina Schmidt,Maria Ripper,Ines Tegtmeier et al.
Katharina Schmidt et al.
Genetically modified mice represent important models for elucidating renal pathophysiology, but gene deletions frequently cause severe failure to thrive. In such cases, the analysis of the phenotype is often limited to the first weeks of li...
Glutathione is a low-affinity substrate of the human sodium-dependent dicarboxylate transporter [0.03%]
谷胱甘肽是人钠依赖性二羧酸转运蛋白的低亲和力底物
Lena Schorbach,Wolfgang Krick,Gerhard Burckhardt et al.
Lena Schorbach et al.
Background/aims: During a single pass through the kidneys, more than 80% of glutathione (GSH) is excreted, indicating not only glomerular filtration, but also tubular secretion. The first step in tubular secretion is the ...
KCNJ10 mutations display differential sensitivity to heteromerisation with KCNJ16 [0.03%]
KCNJ10突变体与KCNJ16异聚化敏感性不同
Sophie Parrock,Sofia Hussain,Naomi Issler et al.
Sophie Parrock et al.
Background/aims: Mutations in the inwardly-rectifying K(+)-channel KCNJ10/Kir4.1 cause autosomal recessive EAST syndrome (epilepsy, ataxia, sensorineural deafness and tubulopathy). KCNJ10 is expressed in the distal convol...
Adenosine effects on renal function in the rat: role of sodium intake and cytochrome P450 [0.03%]
腺苷对大鼠肾功能的影响：钠摄入量和细胞色素P450的作用
Marta Kuczeriszka,Leszek Dobrowolski,Agnieszka Walkowska et al.
Marta Kuczeriszka et al.
Background/aims: Adenosine (ADO) causes vasodilation in most tissues. In the kidney it can induce vasoconstriction or vasodilation, depending on the prevailing stimulation of A1 or A2 receptors (A1R, A2R). ADO-induced alt...
Variations of dietary salt and fluid modulate calcium and magnesium transport in the renal distal tubule [0.03%]
膳食盐分和液体的变化调节远端肾小管中的钙和镁转运
Chien-Te Lee,Yeong-Hau H Lien,Li-Wen Lai et al.
Chien-Te Lee et al.
Background: The renal distal tubule fine-tunes renal epithelial calcium transport. Dietary intake of salt and fluid varies day-to-day and the kidney adapts accordingly to maintain homeostasis. The alternations in salt and...
Guy M L Perry,Steven J Scheinman,John R Asplin
Guy M L Perry
Background: Homoscedasticity (constant variance over axes or among statistical factors) is an integral assumption of most statistical analyses. However, a number of empirical studies in model organisms and humans demonstr...
Non-natriuretic doses of furosemide: potential use for decreasing the workload of the renal outer medulla with minimal magnesium wasting in the rat [0.03%]
小剂量呋塞米：在大鼠中的潜在应用——减少肾外髓质工作量，且几乎不浪费镁离子
Namhee Kim,Surinder Cheema-Dhadli,Gregory M T Hare et al.
Namhee Kim et al.
Background/aims: Since furosemide (FS) inhibits active Na(+) reabsorption by medullary thick ascending limb (mTAL) in the renal outer medulla, it may decrease its work during periods of low O2 supply to deep in the renal ...
Nephrocalcinosis (enamel renal syndrome) caused by autosomal recessive FAM20A mutations [0.03%]
由FAM20A自体显性变异引起的肾钙质沉积病(牙本质发育不全综合征)
Graciana Jaureguiberry,Muriel De la Dure-Molla,David Parry et al.
Graciana Jaureguiberry et al.
Background/aims: Calcium homeostasis requires regulated cellular and interstitial systems interacting to modulate the activity and movement of this ion. Disruption of these systems in the kidney results in nephrocalcinosi...