Acute kidney injury: new concepts. Hepatorenal syndrome: the role of vasopressors [0.03%]
急性肾损伤的新概念及肝肾综合征的血管收缩剂治疗作用
Richard Moreau,Didier Lebrec
Richard Moreau
Type 1 hepatorenal syndrome (HRS) is prerenal failure specific to decompensated cirrhosis. In patients with HRS, there is marked splanchnic/systemic vasodilation resulting in arterial hypotension, arterial baroreceptor unloading, overstimul...
Peter A McCullough
Peter A McCullough
Many radiographic studies and procedures use iodinated contrast media and consequently pose the risk of contrast-induced acute kidney injury (AKI). This is an important complication, which accounts for a significant number of cases of hospi...
Cardiac surgery-associated acute kidney injury: putting together the pieces of the puzzle [0.03%]
心脏手术相关急性肾损伤：拼凑谜题的各部分
Andrew Shaw,Madhav Swaminathan,Mark Stafford-Smith
Andrew Shaw
Background: Acute kidney injury (AKI) is a common problem in the context of cardiac surgery. There are both similarities and differences with AKI occurring in other clinical scenarios. In this paper, we discuss those aspe...
Very-low-density lipoprotein-induced triglyceride accumulation in human mesangial cells is mainly mediated by lipoprotein lipase [0.03%]
极低密度脂蛋白诱导的人系膜细胞甘油三酯积聚主要由脂蛋白脂肪酶介导
Jing Li,Hang Li,Yu-bing Wen et al.
Jing Li et al.
Background: Very-low-density lipoprotein (VLDL) in vitro can induce foam cell formation in human mesangial cells. Lipoprotein lipase (LPL) expressed in the arterial wall plays a key role in atherogenesis by actions of enz...
Increased acid load and deletion of AE1 increase Slc26a7 expression [0.03%]
增加的酸性负荷和AE1的缺失可提高Slc26a7的表达量
Xuming Sun,Snezana Petrovic
Xuming Sun
Background/aims: Slc26a7 is a member of a family of anion transport proteins, Solute-Linked Carrier 26 (Slc26). Slc26a7, which can mediate Cl-/HCO3- exchange, is expressed in the acid-secreting, A-intercalated cells of th...
Saireito and saikosaponin D prevent urinary protein excretion via glucocorticoid receptor in adrenalectomized WKY rats with heterologous-phase anti-GBM nephritis [0.03%]
莎蕊亭和柴胡皂苷D通过肾上腺切除WKY大鼠异种抗基底膜肾炎的糖皮质激素受体防止尿蛋白排泄
Tomohisa Hattori,Hiroaki Nishimura,Yoshio Kase et al.
Tomohisa Hattori et al.
Aims: In order to clarify the antinephritic mechanisms of saireito, the glucocorticoid receptor agonistic effect of saireito was evaluated in adrenalectomized rats with anti-glomerular basement membrane (anti-GBM) nephrit...
Michael Kaye
Michael Kaye
Background: Normal young individuals excrete more sodium in their urine during the day than overnight, but the reverse occurs in older individuals with nocturia. The reason is unknown. ...
A metabonomic and proteomic analysis of changes in IMCD3 cells chronically adapted to hypertonicity [0.03%]
高渗性慢性适应对IMCD3细胞代谢组学及蛋白质组学改变的影响分析
Jost Klawitter,Christopher J Rivard,Lewis M Brown et al.
Jost Klawitter et al.
Background: The genomic response to adaptation of IMCD3 cells to hypertonicity results in both upregulation and downregulation of a variety of genes. Meth...
Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemia [0.03%]
非尿酸性和高尿酸性5/6肾切除大鼠模型中febuxostat对肾脏疾病进展的影响
Laura G Sánchez-Lozada,Edilia Tapia,Virgilia Soto et al.
Laura G Sánchez-Lozada et al.
Background/aims: The effect of febuxostat (Fx), a non-purine and selective xanthine oxidase inhibitor, on glomerular microcirculatory changes in 5/6 nephrectomy (5/6 Nx) Wistar rats with and without oxonic acid (OA)-induc...