Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats [0.03%]
氢气吸入对预防大鼠对比剂致急性肾损伤的益处
Koichiro Homma,Tadashi Yoshida,Maho Yamashita et al.
Koichiro Homma et al.
Background: The present study aimed at investigating the effect of a novel antioxidant, hydrogen (H2) gas, on the severity of contrast-induced acute kidney injury (CIAKI) in a rat model. Methods: CIAKI was induced in rats by intravenous inj...
Polyuria in Hantavirus Infection Reflects Disease Severity and Is Associated with Prolonged Hospital Stay: A Systematic Analysis of 335 Patients from Southern Germany [0.03%]
汉坦病毒血症的多尿反映疾病的严重程度并导致住院时间延长：对来自德国南部的335名患者的系统分析
Joerg Latus,Daniel Kitterer,Juergen Dippon et al.
Joerg Latus et al.
Background/Aims: Puumala virus (PUUV) infection leads to nephropathia epidemica (NE), especially in endemic areas in Central Europe. The clinical course of NE is characterized by acute kidney injury (AKI) with thrombocytopenia followed by p...
Stimulation of Cyclooxygenase 2 Expression in Rat Peritoneal Mesothelial Cells [0.03%]
大鼠腹膜间皮细胞中环氧合酶-2表达的诱导
Michael E Ullian,Louis M Luttrell,Mi-Hye Lee et al.
Michael E Ullian et al.
Objective: Since peritoneal dialysis causes peritoneal fibrosis, we examined how glucose (osmotic factor), mannitol (osmotic control), and angiotensin II (AngII) regulate proinflammatory cyclooxygenase 2 (COX-2) in primary rat peritoneal me...
Beneficial Effects of AMP-Activated Protein Kinase Agonists in Kidney Ischemia-Reperfusion: Autophagy and Cellular Stress Markers [0.03%]
AMP激活的蛋白激酶激动剂在肾脏缺血再灌注中的积极作用：自噬和细胞应激标志物
Anne-Emilie Declèves,Kumar Sharma,Joseph Satriano
Anne-Emilie Declèves
Background: Kidney ischemia-reperfusion is a form of acute kidney injury resulting in a cascade of cellular events prompting rapid cellular damage and suppression of kidney function. A cellular response to ischemic stress is the activation ...
Wnt5a is necessary for normal kidney development in zebrafish and mice [0.03%]
斑马鱼和小鼠正常肾脏发育需要Wnt5a基因
Liwei Huang,An Xiao,Soo Young Choi et al.
Liwei Huang et al.
Background: Wnt5a is important for the development of various organs and postnatal cellular function. Little is known, however, about the role of Wnt5a in kidney development, although WNT5A mutations were identified in pa...
Protective effects of relaxin against cisplatin-induced nephrotoxicity in rats [0.03%]
Relaxin对顺铂致大鼠肾毒性的保护作用研究
Takuya Yoshida,Hiromichi Kumagai,Tetsuya Kohsaka et al.
Takuya Yoshida et al.
Background: Cisplatin (CDDP)-induced acute kidney injury (AKI) involves pro-inflammatory responses, apoptosis of renal tubular epithelial cells and vascular damage. AKI increases the risk of chronic kidney disease. Relaxi...
Multiple mechanisms in renal artery stenosis-induced renal interstitial fibrosis [0.03%]
肾动脉狭窄介导的肾脏间质纤维化的发病机制研究进展
Rui Cui,Xiao Chen,Lei Peng et al.
Rui Cui et al.
Background/aims: Renal artery stenosis (RAS), which may lead to renal fibrosis, is a common cause of end-stage renal disease in elderly patients. However, the potential mechanisms leading to the development of renal fibro...
Increased macrophage activation inhibited by tacrolimus in the kidney of diabetic rats [0.03%]
糖皮质激素诱导糖尿病大鼠肾脏巨噬细胞活化增强及其他克莫司抑制作用研究
Yonggui Wu,Yan Wang,Xiangming Qi et al.
Yonggui Wu et al.
Background/aims: Accumulating evidence suggests that macrophage-induced inflammation may be the mechanism of development and progression of diabetic nephropathy. A previous study by our group has shown that tacrolimus, li...
Xin Wan,Wen Juan Huang,Wen Chen et al.
Xin Wan et al.
Background: Renal ischemia-reperfusion (IR) injury is a frequent cause of acute kidney injury, which results in high morbidity and mortality. Inflammation is an important factor that is involved in kidney repair after ren...
Macrophage depletion ameliorates glycerol-induced acute kidney injury in mice [0.03%]
巨噬细胞耗竭缓解甘油诱导的小鼠急性肾损伤
Jin H Kim,Dong-Won Lee,Myeong H Jung et al.
Jin H Kim et al.
Background: This study was conducted to elucidate the role of renal macrophages in the development of acute kidney injury (AKI) in a glycerol (Gly)-induced rhabdomyolysis mouse model. ...