Devaraj Ezhilarasan
Devaraj Ezhilarasan
Relaxin (RLX) is a heterodimeric, polypeptide hormone that has natural anti-fibrotic activity in many organs. During the chronic liver injury, hepatic stellate cells (HSCs) are phenotypically transformed into myofibroblasts. This process is...
The allosteric protein interactions in the proton-motive function of mammalian redox enzymes of the respiratory chain [0.03%]
呼吸链中参与质子动力功能的哺乳动物氧化还原酶的别构蛋白相互作用
Giuseppe Capitanio,Francesco Papa,Sergio Papa
Giuseppe Capitanio
Insight into mammalian respiratory complexes defines the role of allosteric protein interactions in their proton-motive activity. In cytochrome c oxidase (CxIV) conformational change of subunit I, caused by O2 binding to heme a32+-CuB+ and ...
What do secreted phospholipases A2 have to offer in combat against different viruses up to SARS-CoV-2? [0.03%]
分泌型磷脂酶A₂在对抗不同病毒（包括SARS-CoV-2）方面有哪些作用？
Jože Pungerčar,Franck Bihl,Gérard Lambeau et al.
Jože Pungerčar et al.
Secreted phospholipases A2 (sPLA2s) form a widespread group of structurally-related enzymes that catalyse the hydrolysis of the sn-2 ester bond of glycerophospholipids to produce free fatty acids and lysophospholipids. In humans, nine catal...
Skin aquaporins as druggable targets: Promoting health by addressing the disease [0.03%]
皮肤水通道蛋白的药物作用靶点：通过应对疾病来促进健康
Inês V da Silva,Andreia G Silva,Catarina Pimpão et al.
Inês V da Silva et al.
Skin is the most vulnerable organ of the human body since it is the first line of defense, covering the entire external body surface. Additionally, skin has a critical role in thermoregulation, sensation, immunological surveillance, and bio...
Corrigendum to "Wrapping axons in mammals and Drosophila: Different lipids, same principle" [BIOCHIMIE 178C (2020) 39-48] [0.03%]
“哺乳动物和果蝇的轴突缠绕：不同的脂质，相同的原则”一文勘误版
Motohide Murate,Nario Tomishige,Toshihide Kobayashi
Motohide Murate
Published Erratum
Biochimie. 2021 Aug:187:82. DOI:10.1016/j.biochi.2021.05.009 2021
Key amino acid residues in homoserine-acetyltransferase from M. tuberculosis give insight into the evolution of MetX family of enzymes - HAT, SAT and HST [0.03%]
甲硫氨酸菌体霍姆丝氨酸乙酰基转移酶的关键氨基酸有助于了解MetX家族酶的进化：HAT，SAT和HST
Bhavna Maurya,Melwin Colaço,Johan Wouters et al.
Bhavna Maurya et al.
Multiple sequence alignment of homoserine-acetyltransferases, serine-acetyltransferases and homoserine-succinyltransferases show they all belong to MetX family, having evolved from a common ancestor by conserving the catalytic site and subs...
Human sperm functioning is related to the aquaporin-mediated water and hydrogen peroxide transport regulation [0.03%]
人精子的功能与水和过氧化氢的渗透调节有关：水通道蛋白介导机制
Giorgia Pellavio,Umberto Laforenza
Giorgia Pellavio
Aquaporins (AQPs) are transmembrane water channels and some of them are permeable in addition to water to other small solutes including hydrogen peroxide. The sperm cells of mammals and fishes express different AQPs, although there is no ag...
Roles of microRNAs in carbohydrate and lipid metabolism disorders and their therapeutic potential [0.03%]
microRNA在糖脂代谢紊乱中的作用及其治疗潜力
Sujay Paul,Luis Alberto Bravo Vázquez,Samantha Pérez Uribe et al.
Sujay Paul et al.
MicroRNAs (miRNAs) are small (∼21 nucleotides), endogenous, non-coding RNA molecules implicated in the post-transcriptional gene regulation performed through target mRNA cleavage or translational inhibition. In recent years, several invest...
De novo pathway is an active metabolic pathway of cysteine synthesis in Haemonchus contortus [0.03%]
血红虫科线虫半胱氨酸合成的新陈代谢途径研究
Vijay Kumar Saxena,G V Vedamurthy,C P Swarnkar et al.
Vijay Kumar Saxena et al.
Haemonchus contortus, commonly known as Barber's pole worm, is an economically important gastrointestinal nematode of sheep and goats especially in tropical and sub-tropical regions of the world. Cysteine synthesis is a very important metab...
Essential sufficiency of zinc, ω-3 polyunsaturated fatty acids, vitamin D and magnesium for prevention and treatment of COVID-19, diabetes, cardiovascular diseases, lung diseases and cancer [0.03%]
锌、ω-3多不饱和脂肪酸、维生素D和镁对预防和治疗新冠肺炎、糖尿病、心血管疾病、肺部疾病和癌症的重要性
Michael J Story
Michael J Story
Despite the development of a number of vaccines for COVID-19, there remains a need for prevention and treatment of the virus SARS-CoV-2 and the ensuing disease COVID-19. This report discusses the key elements of SARS-CoV-2 and COVID-19 that...