Crystal structure and characterization of nucleoside diphosphate kinase from Vibrio cholerae [0.03%]
霍乱弧菌核苷二磷酸激酶的晶体结构和特性研究
Pragati Agnihotri,Anil Kumar Shakya,Arjun K Mishra et al.
Pragati Agnihotri et al.
Nucleoside diphosphate kinases (NDK) are ubiquitous enzymes that catalyse the transfer of the γ phosphate from nucleoside triphosphates (NTPs) to nucleoside diphosphate (NDPs), to maintain appropriate NTP levels in cells. NDKs are associat...
HIV-1 Tat: An update on transcriptional and non-transcriptional functions [0.03%]
HIV-1 Tat：转录和非转录功能新进展
Amjad Ali,Ritu Mishra,Harsimrut Kaur et al.
Amjad Ali et al.
Over the past decades, much have been learned about HIV-1 virus and its molecular strategies for pathogenesis. However, HIV-1 still remains an enigmatic virus, particularly because of its unique proteins. Establishment of latency and reacti...
The biochemical association between R157H mutation in human αB-crystallin and development of cardiomyopathy: Structural and functional analyses of the mutant protein [0.03%]
人αB-晶状体蛋白R157H突变与心肌病发生之间的生化联系：突变蛋白质的结构和功能分析
Parto Nasiri,Maryam Ghahramani,Zohreh Tavaf et al.
Parto Nasiri et al.
In human αB-crystallin or HspB5, the substitution of arginine residue at position 157 with histidine has been reported to cause cardiomyopathy. In this study, the impact of R157H mutation on the structure, stability and functional properti...
Citrin deficiency: Does the reactivation of liver aralar-1 come into play and promote HCC development? [0.03%]
瓜氨酸血症Ⅱ型肝细胞癌发生机制的研究进展及展望
Karine Mention,Marie Joncquel Chevalier Curt,Anne-Frédérique Dessein et al.
Karine Mention et al.
Hepatocellular carcinoma (HCC) is a longstanding issue in clinical practice and metabolic research. New clues in better understanding the pathogenesis of HCC might relate to the metabolic context in patients with citrin (aspartate-glutamate...
Cellular binding and uptake of fluorescent glucose analogs 2-NBDG and 6-NBDG occurs independent of membrane glucose transporters [0.03%]
荧光葡萄糖类似物2-NBDG和6-NBDG的细胞结合和摄取独立于膜葡萄糖转运蛋白发生
Kathryn E Hamilton,Miranda F Bouwer,Larry L Louters et al.
Kathryn E Hamilton et al.
The classical methods for determining glucose uptake rates in living cells involve the use of isotopically labeled 2-deoxy-d-glucose or 3-O-methyl-d-glucose, which enter cells via well-characterized membrane transporters of the SLC2A and SL...
The protein-bound uremic toxin p-cresyl-sulfate promotes intracellular ROS production and lipid peroxidation in 3T3-L1 adipose cells [0.03%]
蛋白质结合的尿毒症毒素对甲基硫酸盐促进3T3-L1脂肪细胞内的ROS产生及脂质过氧化反应
Laetitia Koppe,Marine L Croze,Elisa B Monteiro et al.
Laetitia Koppe et al.
Patients with chronic kidney disease (CKD) often exhibit increased level of oxidative stress that contribute to the deterioration of renal function and uremic complications. White adipose tissue (WAT) has been recognized as a major site of ...
Muscles proteome analysis; irisin administration mimics some molecular effects of exercise in quadriceps muscle [0.03%]
肌肉蛋白质组分析；肌肽给药模仿四头肌的某些分子运动效应
Sedigheh Momenzadeh,Saeed Zamani,Zahra Pourteymourfard-Tabrizi et al.
Sedigheh Momenzadeh et al.
Because of health-promoting effects, the adaptation of skeletal muscles to exercise is considered a therapeutic strategy for metabolic complications and musculoskeletal disabilities. Myokines display many beneficial effects of different exe...
Analysis of the mechanisms of action of isopentenyl caffeate against Leishmania [0.03%]
异戊烯咖啡酸抗利什曼原虫的作用机制分析研究论文发布
Simone S C Oliveira,Carine S F Marques,Damião P de Sousa et al.
Simone S C Oliveira et al.
Leishmaniasis is a neglected parasitic disease for which the conventional treatment can be considered inefficient and extremely aggressive, generating several and severe side effects. Therefore, the discovery of new drug candidates is impor...
The knockdown efficiency of telomere associated genes with specific methodology in a zebrafish cell line [0.03%]
特异性方法在斑马鱼细胞系中检测端粒相关基因的敲除效率
Xuefei Hu,Shuaiyun Gao,Peng Wang et al.
Xuefei Hu et al.
Zebrafish is broadly used as a model organism in gene loss-of-function studies in vivo, but its employment in vitro is greatly limited by the lack of efficient gene knockdown approaches in zebrafish cell lines such as ZF4. In this article, ...
Anastasia L Khandazhinskaya,Vincenzo Mercurio,Anna A Maslova et al.
Anastasia L Khandazhinskaya et al.
Despite the development of efficient anti-human immunodeficiency virus-1 (HIV-1) therapy, HIV-1 associated pathogens remain a major clinical problem. Human cytomegalovirus (CMV) is among the most common HIV-1 copathogens and one of the main...