Di Li,Jihua Guo,Rong Jia
Di Li
SPIN1 is a histone methylation reader, which can epigenetically control multiple tumorigenesis-associated signaling pathways, including the Wnt, PI3K/AKT, and RET pathways. Considerable evidence has shown that SPIN1 is overexpressed in many...
A review emphasizing on utility of heptad repeat sequence as a tool to design pharmacologically safe peptide-based antibiotics [0.03%]
以七联体重复序列为工具设计药理安全的肽类抗生素的研究综述
Vikas Yadav,Richa Misra
Vikas Yadav
Extensive usage of antibiotics has created an unprecedented scenario of the rapid emergence of many drug-resistant bacteria, which has become an alarming public health concern around the globe. Search for better alternatives that are as eff...
A mass spectrometric approach to study the interaction of amyloid β peptides with human α-2-macroglobulin [0.03%]
一种用于研究淀粉样蛋白β肽与人α-2巨球蛋白相互作用的质谱方法
Aleksandr Viktorovich Protasov,Olga Alexandrovna Mirgorodskaya,Yuri Petrovich Kozmin et al.
Aleksandr Viktorovich Protasov et al.
We used MALDI-MS to study the interaction of amyloid β (Aβ) peptides with alpha-2-macroglobulin (α2M). The binding of amyloid beta (Aβ) peptides to alpha-2-macroglobulin (α2M) was found to inhibit the ability of trypsin to cleave out t...
Biochemical aspects of hemoglobin-xenobiotic interactions and their implications in drug discovery [0.03%]
血红蛋白-外源物质相互作用的生化方面及其在药物发现中的意义
Mehta Gaurav,Ahuja Natesh,Abhyankar Arundhati et al.
Mehta Gaurav et al.
Hemoglobin, a homodimeric globular protein, is found predominantly in red blood cells and in a small amount in blood plasma. Along with binding to certain native molecules, it also interacts with various xenobiotics. The present review aims...
Adipose-derived stem/stromal cell secretome modulates breast cancer cell proliferation and differentiation state towards aggressiveness [0.03%]
来源于脂肪组织干细胞/基质细胞分泌组调控乳腺癌细胞的增殖及其向侵袭性表型分化的状态
Marcelo Coutinho de Miranda,Andrea da Fonseca Ferreira,Mariane Izabella Abreu de Melo et al.
Marcelo Coutinho de Miranda et al.
It is becoming increasingly evident that mesenchymal stem/stromal cells are recruited by cancer cells from nearby endogenous host stroma and promote events such as tumor proliferation, angiogenesis, invasion, and metastasis, as well as medi...
Differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-HT1A, GABA, glutamate receptor expression in the rat prefrontal cortex [0.03%]
不同剂量的甲基苯环丙胺增强和抑制记忆对大鼠前额叶皮质血清素代谢及5-ht1a、gaba、谷氨酸受体表达的影响不同
Tabinda Salman,Rushda Afroz,Shazia Nawaz et al.
Tabinda Salman et al.
Methylphenidate (MPD), a psychostimulant, is a prescription medicine for treating attention deficit hyperactivity disorder (ADHD). Previously we have shown that moderate doses of MPD enhanced learning and memory while higher doses impaired ...
A novel anionic cathelicidin lacking direct antimicrobial activity but with potent anti-inflammatory and wound healing activities from the salamander Tylototriton kweichowensis [0.03%]
来自中国火唇疣螈(Tylototriton kweichowensis)的新型阴性囊状 кателицидин,其无直接抗菌活性但具有强大的抗炎和促伤口愈合作用
Xuanjin Luo,Jianhong Ouyang,Yan Wang et al.
Xuanjin Luo et al.
Cathelicidin is a family of antimicrobial peptides (AMPs) existing in vertebrates, which play multiple functions in host responses against environmental stresses. All cathelicidins identified to date are cationic, no anionic member with net...
Phylogenetics and biochemistry elucidate the evolutionary link between l-malate and l-lactate dehydrogenases and disclose an intermediate group of sequences with mix functional properties [0.03%]
系统发育和生化阐明了L-苹果酸和L-乳酸脱氢酶之间的进化联系，并揭示了一组功能混合的中间序列
Céline Brochier-Armanet,Dominique Madern
Céline Brochier-Armanet
The NAD(P)-dependent malate dehydrogenases (MDH) (EC 1.1.1.37) and NAD-dependent lactate dehydrogenases (LDH) (EC. 1.1.1.27) form a large superfamily that has been characterized in organisms belonging to the three Domains of Life. MDH catal...
Oxidative probing of the G4 DNA structure induced in double-stranded DNA by molecular crowding or pyridostatin [0.03%]
分子拥挤或Pyridostatin诱导的双链DNA中G4结构的氧化探针研究
Artemy Beniaminov,Galina Chashchina,Anna Shchyolkina et al.
Artemy Beniaminov et al.
Major advances have been made recently in the application of the highly selective G4 DNA ligand pyridostatin (PDS) for targeting and visualization of this noncanonical DNA structure in eukaryotic genomes. However, the interaction of PDS wit...
EGCG as an anti-SARS-CoV-2 agent: Preventive versus therapeutic potential against original and mutant virus [0.03%]
EGCG作为抗SARS-CoV-2的药物：对原始病毒和突变株预防与治疗潜力的对比研究
Vladimir Tsvetkov,Anna Varizhuk,Liubov Kozlovskaya et al.
Vladimir Tsvetkov et al.
In the search for anti-SARS-CoV-2 drugs, much attention is given to safe and widely available native compounds. The green tea component epigallocatechin 3 gallate (EGCG) is particularly promising because it reportedly inhibits viral replica...