Experimental models of lipid overload and their relevance in understanding skeletal muscle insulin resistance and pathological changes in mitochondrial oxidative capacity [0.03%]
脂质过载的实验模型及其在理解骨骼肌胰岛素抵抗和线粒体氧化能力病理变化中的相关性
Sinenhlanhla X H Mthembu,Phiwayinkosi V Dludla,Tawanda M Nyambuya et al.
Sinenhlanhla X H Mthembu et al.
It remains essential to decipher some of the pathological mechanisms that link obesity with deteriorating human health. Insulin resistance, due to enhanced free fatty acid substrate delivery, results in disrupted glucose homeostasis and alt...
The ADP-glucose pyrophosphorylase from Melainabacteria: a comparative study between photosynthetic and non-photosynthetic bacterial sources [0.03%]
来自Melainabacteria的ADP-葡萄糖焦磷酸酶：光合和非光合细菌来源的比较研究
María V Ferretti,Rania A Hussien,Miguel A Ballicora et al.
María V Ferretti et al.
Until recently, the cyanobacterial phylum only included oxygenic photosynthesizer members. The discovery of Melainabacteria as a group of supposed non-photosynthetic cyanobacteria asked to revisit such scenario. From metagenomic data, we we...
Comparative Study
Biochimie. 2022 Jan:192:30-37. DOI:10.1016/j.biochi.2021.09.011 2022
On the footsteps of Hippocrates, Sanctorius and Harvey to better understand the influence of cold on the occurrence of COVID-19 in European countries in 2020 [0.03%]
从希波克拉底、圣托里奥和哈维的脚步中更好地了解寒冷在2020年对欧洲各国COVID-19发生的影响
Philippe Icard,Luca Simula,Joana Rei et al.
Philippe Icard et al.
COVID-19 pandemic has been characterized by a pattern of consecutive declines and regrowth in European countries in 2020. After being partially regressed during the summer, the reappearance of the infection during fall 2020 in many temperat...
Hinokitiol-induced decreases of tyrosinase and microphthalmia-associated transcription factor are mediated by the endoplasmic reticulum-associated degradation pathway in human melanoma cells [0.03%]
hinokitiol诱导的人黑色素瘤细胞中酪氨酸酶和与小眼畸形相关转录因子减少是由内质网关联降解途径介导的
Takahiro Oyama,Haruka Ogawa,Yoko Shirai et al.
Takahiro Oyama et al.
Tyrosinase (TYR) is a key enzyme for melanin production. We previously showed that hinokitiol, a naturally occurring seven-membered ring terpenoid, potently inhibits human TYR activity. Interestingly, hinokitiol was recently reported to dec...
Bernhard Redl,Matthias Habeler
Bernhard Redl
Lipocalins are important carriers of preferentially hydrophobic molecules, but they can also bind other ligands, like highly polar siderophores or intact proteins. Consequently, they are involved in a variety of physiological processes in m...
Leandro Oliveira Bortot,Victor Lopes Rangel,Francesca A Pavlovici et al.
Leandro Oliveira Bortot et al.
Prion disease is caused by the misfolding of the cellular prion protein, PrPC, into a self-templating conformer, PrPSc. Nuclear magnetic resonance (NMR) and X-ray crystallography revealed the 3D structure of the globular domain of PrPC and ...
Decreased cortical Nrf2 gene expression in autism and its relationship to thiol and cobalamin status [0.03%]
自闭症患者皮层Nrf2基因表达降低及其与硫醇和钴胺状态的关系
Matthew Scott Schrier,Yiting Zhang,Malav Suchin Trivedi et al.
Matthew Scott Schrier et al.
Nuclear factor erythroid 2-related factor 2 (Nrf2) promotes expression of a large number of antioxidant genes and multiple studies have described oxidative stress and impaired methylation in autism spectrum disorder (ASD), including decreas...
Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines [0.03%]
SARS-CoV-2新兴值得关注的刺突蛋白变异的动力学预测指出了更新疫苗的必要性
Walid Al-Zyoud,Hazem Haddad
Walid Al-Zyoud
The spike protein of SARS-CoV-2 plays a crucial role in binding with the human cell surface, which causes its pathogenicity. This study aimed to predict molecular dynamics change of emerging variants in the spike protein. In this study, sev...
Uncovering a delicate balance between endonuclease RNase III and ribosomal protein S15 in E. coli ribosome assembly [0.03%]
大肠杆菌核糖体组装中内切核酸酶RNase III与核糖体蛋白S15之间的微妙平衡关系
Anusha Naganathan,Roxanne Keltz,Hiram Lyon et al.
Anusha Naganathan et al.
The bacterial ribosomal protein S15 is located in the platform, a functional region of the 30S ribosomal subunit. While S15 is critical for in vitro formation of E. coli small subunits (SSUs), it is dispensable for in vivo biogenesis and gr...
Novel G-quadruplex prone sequences emerge in the complete assembly of the human X chromosome [0.03%]
完整组装的人类X染色体中出现了新的G-四链体倾向序列
Natália Bohálová,Jean-Louis Mergny,Václav Brázda
Natália Bohálová
G-quadruplexes are non-B secondary structures with regulatory functions and therapeutic potential. Improvements in sequencing methods recently allowed the completion of the first human chromosome which is now available as a gapless, end-to-...