Pancreatic islet cells disarray, apoptosis, and proliferation in obese mice. The role of Semaglutide treatment [0.03%]
肥胖小鼠胰岛细胞紊乱、凋亡和增殖。塞玛格鲁肽治疗的作用
Thatiany de Souza Marinho,Fabiane Ferreira Martins,Luiz Eduardo de Macedo Cardoso et al.
Thatiany de Souza Marinho et al.
There are significant injuries of pancreatic islets due to obesity and insulin resistance. Therefore, GLP-1 receptor agonists like Semaglutide might benefit the islet structural remodeling and its endocrine function in diet-induced obese mi...
Contrary to consensus, oxidation of ethanol by human alcohol dehydrogenase (ADH) 1A is activated by ATP [0.03%]
与共识相反，乙醇被人类酒精脱氢酶（ADH）1A氧化被ATP激活
Igor Khmelinskii,Vladimir I Makarov
Igor Khmelinskii
Presently we report that enzymatic oxidation of ethanol (EtOH) by ADH1A alcohol dehydrogenase is strongly accelerated in presence of adenosine triphosphate (ATP), by up to the factor of 20 in vitro. This result provides a different look on ...
Human transcriptional gene regulatory network compiled from 14 data resources [0.03%]
整合14种数据资源构建人类转录基因调控网络
Vijaykumar Yogesh Muley,Rainer König
Vijaykumar Yogesh Muley
The transcriptional regulatory network (TRN) in a cell orchestrates spatio-temporal expression of genes to generate cellular responses for maintenance, reproduction, development and survival of the cell and its hosting organism. Transcripti...
Arun-Kumar Kaliya-Perumal,Philip W Ingham
Arun-Kumar Kaliya-Perumal
Musculoskeletal injuries are common in humans. The cascade of cellular and molecular events following such injuries results either in healing with functional recovery or scar formation. While fibrotic scar tissue serves to bridge between in...
Unravelling the molecular interactions between the SARS-CoV-2 RBD spike protein and various specific monoclonal antibodies [0.03%]
揭开SARS-CoV-2 病毒RBD刺突蛋白与各种特异性单克隆抗体的分子相互作用的关系
Didac Martí,Marc Alsina,Carlos Alemán et al.
Didac Martí et al.
Vaccination against SARS-CoV-2 just started in most of the countries. However, the development of specific vaccines against SARS-CoV-2 is not the only approach to control the virus and monoclonal antibodies (mAbs) start to merit special att...
Pathogenic role of mitogen activated protein kinases in protozoan parasites [0.03%]
原生动物寄生虫中丝裂原激活的蛋白激酶的作用
Pavneet Kaur,Neena Goyal
Pavneet Kaur
Protozoan parasites with complex life cycles have high mortality rates affecting billions of human lives. Available anti-parasitic drugs are inadequate due to variable efficacy, toxicity, poor patient compliance and drug-resistance. Hence, ...
Zinc oxide nanoparticle interface moderation with tyrosine and tryptophan reverses the pro-amyloidogenic property of the particle [0.03%]
酪氨酸和色氨酸调节氧化锌纳米粒子界面可逆转该颗粒的促淀粉样蛋白性质
Kanti Kusum Yadav,Monalisha Ojha,Ranit Pariary et al.
Kanti Kusum Yadav et al.
Zinc oxide nanoparticle with negative surface potential (ZnONP) enhances bovine insulin fibrillation. Here, we are exploring ZnONP with positive surface potential (ZnONPUnc) and surface functionalized with tyrosine and tryptophan amino acid...
Mechanistic physicochemical insights into glycation and drug binding by serum albumin: Implications in diabetic conditions [0.03%]
血清白蛋白对糖基化和药物结合的机理物理化学研究：在糖尿病情况下的意义
Ritutama Ghosh,Nand Kishore
Ritutama Ghosh
The drug binding ability of serum albumin might get affected as a result of its glycation under diabetic conditions. It requires not only an understanding of the effect of glycation of the protein upon association with the drug, but also ca...
Blood derived extracellular vesicles as regenerative medicine therapeutics [0.03%]
血液来源的细胞外囊泡作为再生医学治疗剂
Candice de Boer,Neil Hamer Davies
Candice de Boer
The regenerative promise of nanosized extracellular vesicles (EVs) secreted by cells is widely explored. Recently, the capacity of EVs purified from blood to elicit regenerative effect has begun to be evaluated. Blood might be a readily ava...
Shaping the gut microbiota by bioactive phytochemicals: An emerging approach for the prevention and treatment of human diseases [0.03%]
通过植物化学物质调节肠道微生物群：一种新兴的预防和治疗人类疾病的方法
Surya Sudheer,Prateeksha Gangwar,Zeba Usmani et al.
Surya Sudheer et al.
The human digestive tract is the cottage to trillions of live microorganisms, which regulate health and illness. A healthy Gut Microbiota (GM) is necessary for preventing microbial growth, body growth, obesity, cancer, diabetes, and enhanci...