Gene cluster from plant to microbes: Their role in genome architecture, organism's development, specialized metabolism and drug discovery [0.03%]
从植物到微生物的基因簇：它们在基因组结构、生物体发育、次级代谢和药物发现中的作用
Prasanta Chakraborty
Prasanta Chakraborty
Plants and microbes fulfil our daily requirements through different high-value chemicals, e.g., nutraceuticals, pharmaceuticals, cosmetics, and through varieties of fruits, crops, vegetables, and many more. Utmost care would therefore be ta...
Oxidative distress in aging and age-related diseases: Spatiotemporal dysregulation of protein oxidation and degradation [0.03%]
衰老及相关疾病中的氧化应激：蛋白质氧化和降解的时空失调
Sergey Zavadskiy,Susanna Sologova,Nurbubu Moldogazieva
Sergey Zavadskiy
The concept of oxidative distress had arisen from the assessment of cellular response to high concentrations of reactive species that result from an imbalance between oxidants and antioxidants and cause biomolecular damage. The intracellula...
N C Sibisi,C Snyman,K H Myburgh et al.
N C Sibisi et al.
Skeletal muscle injury activates satellite cells to proliferate as myoblasts and migrate, differentiate and fuse with existing fibres at the site of injury. Nitric oxide (NO), a free radical produced by NO synthase, is elevated and supports...
Yuchen Ge,Min Zhou,Cui Chen et al.
Yuchen Ge et al.
AMPK is an important kinase regulating energy homeostasis and also a key protein involved in a variety of signal transduction pathways. It plays a vitally regulatory role in cellular senescence. Activation of AMPK can delay or block the agi...
Structural and mechanistic insights into the substrate specificity and hydrolysis of GH31 α-N-acetylgalactosaminidase [0.03%]
GH31 α-N-乙酰半乳糖胺酶对底物特异性和水解的结构和机理研究
Takatsugu Miyazaki,Marina Ikegaya,Santiago Alonso-Gil
Takatsugu Miyazaki
Glycoside hydrolase family 31 (GH31) is a diversified family of anomer-retaining α-glycoside hydrolases, such as α-glucosidase and α-xylosidase, among others. Recently, GH31 α-N-acetylgalactosaminidases (Nag31s) have been identified to ...
AICAR stimulates mitochondrial biogenesis and BCAA catabolic enzyme expression in C2C12 myotubes [0.03%]
AICAR刺激C2C12肌管中的线粒体生物发生和BCAA分解代谢酶的表达
Jason S Hinkle,Caroline N Rivera,Roger A Vaughan
Jason S Hinkle
Type 2 diabetes is characterized by reduced insulin sensitivity, elevated blood metabolites, and reduced mitochondrial metabolism. Insulin resistant populations often exhibit reduced expression of genes governing mitochondrial metabolism su...
SARS-CoV-2 may affect the immune response via direct inhibition of T cell receptor: Mechanistic hypothesis and rationale [0.03%]
SARS-CoV-2可能通过直接抑制T细胞受体影响免疫反应：机制假设和依据
Alexander B Sigalov
Alexander B Sigalov
During co-evolution with their hosts, many viruses have evolved a membrane fusion mechanism to facilitate host cell entry. Examples are human immunodeficiency virus type 1 (HIV-1) and severe acute respiratory syndrome coronaviruses 1 and 2 ...
Template requirements of Zika RNA polymerase during in vitro RNA synthesis from the 3'-end of virus minus-strand RNA [0.03%]
寨卡病毒RNA聚合酶在以病毒负链RNA的3'端为模板进行体外转录时对模板的要求
Christina Calmels,Mathieu Métifiot,Marie-Line Andreola
Christina Calmels
As ZIKV continues to spread, many "unknowns" remain and research is needed to advance the understanding of this important pathogen. Viral RNA dependent-RNA polymerases (RdRp) are validated targets for inhibitors of the replication of severa...
Crystallographic and biophysical analyses of Pseudomonas aeruginosa ketopantoate reductase: Implications of ligand induced conformational changes in cofactor recognition [0.03%]
铜绿假单胞菌酮戊二酸还原酶的晶体学和生物物理学分析：底物诱导的构象变化对辅因子识别的影响
Arkaprabha Choudhury,Basavraj Khanppnavar,Saumen Datta
Arkaprabha Choudhury
Ketopantoate reductases (KPRs) catalyse NADPH-dependent reduction of ketopantoate to pantoate, the rate-limiting step of pantothenate biosynthetic pathway. In our recent study, we showed KPRs are under dynamic evolutionary selection and hig...
A regulatory role of circRNA-miRNA-mRNA network in osteoblast differentiation [0.03%]
circRNA-miRNA-mRNA网络在成骨细胞分化中的调控作用
R Mohanapriya,R L Akshaya,N Selvamurugan
R Mohanapriya
Osteoblast differentiation is an important process in skeletal development and bone remodelling. Serious bone diseases occur from any delay, defect, or imbalance in osteoblastic differentiation. Non-coding RNAs (ncRNAs) play a regulatory ro...