R-loops processing by human apurinic/apyrimidinic endonuclease APE1 [0.03%]
人类apurinic/APYRMIDINIC末端内切酶APE1处理R环结构体
Anastasia A Gavrilova,Anastasia M Yakovleva,Elena S Mikushina et al.
Anastasia A Gavrilova et al.
R-loops are three-stranded nucleic acid structures that arise during transcription and play important roles in genome regulation, but their unscheduled accumulation can lead to genomic instability. Apurinic/apyrimidinic endonuclease 1 (APE1...
Biochemical pathways linking adiposity, diet, and endometrial carcinogenesis [0.03%]
肥胖、饮食和子宫内膜癌发生之间的生化途径联系
Mateusz Labudda,Kamil Aleksander Sobieszek,Jakub Frankowski et al.
Mateusz Labudda et al.
Endometrial cancer (EC) arises from a convergence of metabolic, endocrine, and inflammatory disturbances largely driven by excess adiposity and diet-induced biochemical reprogramming. This review synthesizes molecular evidence linking adipo...
Molecular determinants of sugar donor selectivity in MGD1, the major galactolipid synthase in Arabidopsis thaliana [0.03%]
调控拟南芥糖基供体选择性的MGD1分子决定因子
Batoul Moubarak,Dylan Jabeguero,Valérie Chazalet et al.
Batoul Moubarak et al.
Galactolipids are characteristic components of photosynthetic membranes, but the molecular bases explaining the marked preference of plastidial glycolipid synthases for galactose over glucose remains unknown. In Arabidopsis, MONOGALACTOSYLD...
Ancestral origin of the CXCL17-GPR25 system traced to the lobe-finned fish Latimeria chalumnae [0.03%]
非洲肺鱼中追溯CXCL17-GPR25系统的祖先起源
Jie Yu,Juan-Juan Wang,Wen-Feng Hu et al.
Jie Yu et al.
The roles of C-X-C motif chemokine ligand 17 (CXCL17) and its receptor, G protein-coupled receptor 25 (GPR25), in immune regulation are gaining recognition, but their evolutionary origins and phylogenetic distributions have yet to be determ...
Inter and intraspecific variation in Micrurus venoms from Bahia, Brazil and challenges for antivenom efficacy [0.03%]
巴西巴伊亚州Micrurus毒蛇毒性变异及抗蛇毒血清有效性的挑战
Luciana Casais-E-Silva,Tauane Vaccas,Larissa Granna da Silva Leite et al.
Luciana Casais-E-Silva et al.
Although uncommon, coral snake envenoming poses serious risks due to the neurotoxicity of Micrurus venoms. Bahia, Brazil, reports high incidence of bites, yet regional venom variation is poorly understood. This study characterized biochemic...
Inhibition of urease by urea/thiourea-derived heterocycles: IC50 profiling and structure-activity relationship [0.03%]
尿素/硫脲衍生物的杂环化合物抑制尿酶的作用：IC50谱图和构效关系研究
Ali Bağ,Orhan Uluçay
Ali Bağ
The urease enzyme catalyzes the hydrolysis of urea and plays a critical role in both agricultural and clinical contexts, contributing to nitrogen loss from urea-based fertilizers and promoting the survival and virulence of urease-positive p...
Structural and pharmacological analysis of a PLA2-like toxin in complex with the sPLA2 inhibitor AZD2716: Comparisons to varespladib [0.03%]
与sPLA2抑制剂AZD2716结合的PLA2样毒素的结构和药理学分析：与varespladib的比较
Guilherme H M Salvador,Elisa S Pereira,Walter L G Cavalcante et al.
Guilherme H M Salvador et al.
Phospholipase A2 (PLA2) and PLA2-like toxins are key contributors to the local myonecrotic effects induced by Bothrops snake venoms and represent important targets for inhibition. Synthetic molecules such as varespladib (LY315920) and AZD27...
A Single Intra-articular Injection of IDO-Gal3 Shifts Synovial Fluid Metabolic Profiles for up to Six Weeks in Male Rats with Knee Instability [0.03%]
单一关节注射IDO-Gal3可调节膝关节不稳大鼠滑膜液代谢轮廓达六周
Folly M Patterson,Carlos J Cruz,Brittany D Partain et al.
Folly M Patterson et al.
Joint metabolism is a potential therapeutic target space for osteoarthritis. We have previously developed a fusion protein of indoleamine 2,3-dioxygenase and galectin-3 (IDO-Gal3) to shift tryptophan metabolism toward the kynurenine pathway...
Akram A Da&#x;dara,Roshni Gondane,Julia Pacheco et al.
Akram A Da&#x;dara et al.
Schistosomes are intravascular parasitic flatworms that acquire all nutrients necessary for their survival from blood. Here we focus on how the parasites acquire and metabolize an essential nutrient - vitamin B1 (thiamine). Live adult male ...
Metabolic response of Haloferax mediterranei to different amino acids as a nitrogen source: from rich to limiting nitrogen conditions [0.03%]
产盐红球菌对不同氮源的代谢响应：从丰富的氮条件到限制性氮条件
B Zafrilla,M Camacho,V Bautista et al.
B Zafrilla et al.
Haloferax mediterranei, a halophilic archaeon, exhibits remarkable adaptability to nitrogen availability by using a wide range of nitrogen sources, including inorganic compounds and single amino acids. To investigate the organism's transcri...