The Impact of microplastics and nanoplastics on human health: a growing concern [0.03%]
微塑料和纳米塑料对人类健康的影响：一个日益增长的担忧
Lucas Gaillard,Etienne B Blanc,Karine Andréau et al.
Lucas Gaillard et al.
The excessive production and improper disposal of plastic has led to the contamination of all marine and terrestrial ecosystems. The degradation of this debris in the form of micro- and nanoplastics (MNPs) has resulted in the contamination ...
Iron-acquisition-targeted therapy for multidrug-resistant Klebsiella pneumoniae: siderophore-antibiotic conjugates, clinical evidence, and emerging resistance [0.03%]
铁摄取靶向治疗耐多药肺炎克雷伯菌：铁载体-抗生素缀合物、临床证据和新出现的抗性
Sayyidah Syathiroh Afzaruddin,Nur Habibah Ishak,Shahrul Bariyah Sahul Hamid et al.
Sayyidah Syathiroh Afzaruddin et al.
Carbapenem-resistant Klebsiella pneumoniae (K. pneumoniae) (CRKP) is the top-ranked critical-priority pathogen on the 2024 WHO Bacterial Priority Pathogens List, and the convergence of carbapenem resistance with hypervirulence (CR-hvKP) is ...
Repurposing nifedipine as a dual-function adjuvant: potentiating gentamicin activity and disrupting biofilm formation in methicillin-resistant Staphylococcus aureus [0.03%]
尼卡地平的再利用作为双重功能辅助剂：增强甲氧西林耐药金黄色葡萄球菌中庆大霉素活性并破坏生物膜形成
Xiaoyong Huang,Xiaomin Ren,Huiqiang Zhang et al.
Xiaoyong Huang et al.
The diminishing efficacy of gentamicin against methicillin-resistant Staphylococcus aureus (MRSA) necessitates novel adjuvant strategies, prompting our investigation into repurposing the calcium channel blocker nifedipine. Here, we demonstr...
Antibiotics regulate bacterial diversification, niche expansion and evolution under primordial conditions [0.03%]
抗生素通过类原始环境调节细菌分化、生态位拓展和进化
Min Qiu,Yu-Qin He,Shun Li et al.
Min Qiu et al.
Antibiotics or bioactive small molecules and building blocks of life are simultaneously generated in the same chemical reaction networks that led to the origin of life. They play a pivotal yet unexplored role in maintaining the biosphere, p...
The Big Kinship of Proline: Counting Saturated and Unsaturated Secondary Amino Acids of Different Ring Size [0.03%]
庞大的脯氨酸亲缘关系：计数不同环大小的饱和和不饱和二级氨基酸
Tatjana Malycheva,Severin Sasso,Stefan Schuster
Tatjana Malycheva
Proline is a well-known proteinogenic amino acid, which features a unique structure among the canonical amino acids: its side chain forms a ring with the backbone nitrogen atom. There are many other cyclic secondary amino acids of different...
Inhibition of the AdeABC efflux pump reverts levofloxacin resistance in uropathogenic Acinetobacter baumannii [0.03%]
抑制AdeABC外排泵可使尿路致病性鲍曼不动杆菌的莱沃氟沙星耐药性逆转
Subathra Ganesamoorthy,Ashish Kapoor,Kalimuthu Karuppanan et al.
Subathra Ganesamoorthy et al.
Uropathogenic multidrug-resistant Acinetobacter baumannii confers resistance to antimicrobials by its potential virulence mechanism called the Efflux pump system. Resistance-Nodulation-Division transporter (RND), AdeABC, involves fluoroquin...
β-Sitosterol as a nutrient-derived steroidal scaffold in ageing and neurodegenerative disorders: Molecular mechanisms and systems biology insights [0.03%]
β-谷固醇作为营养来源的类固醇支架在衰老和神经退行性疾病中的作用：分子机制和系统生物学见解
Alexander Ravikumar,Sarvesh Sabarathinam
Alexander Ravikumar
Ageing is a major driver of neurodegenerative and neurobehavioral disorders, characterized by interconnected processes such as neuroinflammation, oxidative stress, mitochondrial dysfunction. β-Sitosterol (BS), a diet-derived phytosterol wi...
Identification of inhibitors of an N- Monooxygenase from Aspergillus fumigatus [0.03%]
识别人类病原真菌烟曲霉的一种N-单加氧酶的抑制剂
Kendra B Bufkin,Pablo Sobrado
Kendra B Bufkin
The flavin-dependent N-monooxygenase SidA from Aspergillus fumigatus catalyzes the conversion of L-ornithine to N5-hydroxy-L-ornithine. This product is incorporated into hydroxamate containing siderophores, which are iron chelators required...
Archaea as a Resource for Sustainable Biotechnology: From Extremophiles to Valuable Products [0.03%]
从极端环境古菌到有价值的产物：可持续生物技术的资源宝库
Alaa Hassanien,Imen Saadaoui,Sami Sayadi
Alaa Hassanien
Archaea, a remarkable domain of microorganisms, possess extraordinary survival capabilities that enable them to thrive in the most extreme environments on Earth, including high temperatures, extreme pH, oxygen-deprived habitats, and high sa...
Integrative venomics of the coral snake Micrurus elegans: composition, toxicity, and neutralization by antivenom [0.03%]
米诺鲁斯珊瑚蛇(Micrurus elegans)整合毒素学：组成、毒性及其抗血清中和作用
Vanessa Zarzosa,Emiliano Vázquez-García,Bruno Lomonte et al.
Vanessa Zarzosa et al.
The venoms of Mexican coral snakes remain poorly characterized despite the clinical importance of neurotoxic envenomation. In this study, we present the first comprehensive analysis of Micrurus elegans venom, combining transcriptomic, prote...