Paracrine effect of fibroblasts on the proliferation and differentiation of bovine satellite cells in vitro [0.03%]
成纤维细胞旁分泌效应促进牛肌卫星细胞体外增殖分化的作用研究
Karolina Zygmunt,Kacper Żukowski,Katarzyna Piórkowska et al.
Karolina Zygmunt et al.
The co-culture of fibroblasts and muscle cells is essential for obtaining cultured meat using in vitro techniques. While fibroblasts are known to promote myogenesis through cell-cell interactions, their paracrine effects and associated tran...
Characterisation of Entamoeba histolytica anti-silencing function 1 as a histone chaperone [0.03%]
表征Entamoeba histolytica反基因沉默功能1为组蛋白伴侣
Surajit Gandhi,Dileep Vasudevan
Surajit Gandhi
Anti-silencing function 1 (ASF1) is a highly conserved histone chaperone essential for the dynamics of nucleosome structure, facilitating assembly and histone exchange during important cellular processes such as replication, repair, and tra...
Muhammad Mubashshir,Mohd Ovais
Muhammad Mubashshir
Chemical pollutants bioaccumulate in aquatic animals and can reach humans, causing adverse health effects. Pollution of aquatic ecosystems from industrialization and anthropogenic xenobiotics is a global issue. Poikilothermic animals posses...
Hubert Schaller,Philippe Soudant
Hubert Schaller
Are Traditional Mutant Controls Sufficient to Identify True RNA G-Quadruplex Binding Proteins? [0.03%]
传统变体控制措施能否充分识别真正的RNA-G四链体结合蛋白？
Marc-Antoine Turcotte,Louise Dao Josépha Crespo,Jean-Pierre Perreault
Marc-Antoine Turcotte
G-quadruplexes (G4s) are stable non-canonical RNA structures involved in various regulatory processes, whose recognition by G4-binding proteins (G4BPs) is often studied using affinity purification and biochemical validation. A critical fact...
Design of Competitive Inhibitory Peptides for 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase [0.03%]
竞争性抑制法设计羟基-甲基戊二酰辅酶A还原酶的肽抑制剂研究
Valeriy V Pak,Shomansur Sh Sagdullaev,Aleksandr V Pak
Valeriy V Pak
The effectiveness of statins in preventing hypercholesterolemia and associated cardiovascular diseases has been confirmed for a long time. Statins are competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR). This en...
Munishwar Nath Gupta,Vladimir N Uversky
Munishwar Nath Gupta
The role of intrinsic disorder in enzymes has not attracted the attention which it deserves. This perspective discusses how tails and loops in structured proteins, as well as molten globular protein forms, in spite of being disordered, are ...
The HEK293T cells manage overload by the overexpressed full-length Htt variants via proteasome activation [0.03%]
HEK293T细胞通过激活蛋白酶体应对全长Htt突变体过表达引起的负担
Natalia N Gotmanova,Tatiana V Bobik,Viacheslav A Kriachkov et al.
Natalia N Gotmanova et al.
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a pathological mutation that results in the abnormal expansion of more than 37 consecutive trinucleotide repeats (CAG) in the HTT gene. These repeats enc...
From isoforms to invasion - "How CD44/ESRP1 isoform switching drives metastasis and cancer stemness [0.03%]
从异构体到侵袭——“CD44/ESRP1异构体转换如何驱动转移和癌症干细胞特性"
K Jankowska,W Wójtowicz,M Wierzbinka et al.
K Jankowska et al.
Alternative splicing of cluster of differentiation 44 (CD44), regulated by epithelial splicing regulatory protein 1 (ESRP1), plays a critical role in cancer progression. The switch between CD44 variant (CD44v) and standard (CD44s) isoforms ...
Deadly Innovations: Molecular phylogenetics and evolution of phospholipases A2 toxins in viperid snake venoms [0.03%]
致命的创新：游蛇科蛇毒中磷脂酶A2毒素的分子谱系和进化
Lorenzo Seneci,Vivek Suranse,Marco Mancuso et al.
Lorenzo Seneci et al.
Snake venoms have surged as model systems in evolutionary biology thanks to the dynamic diversification and accelerated evolution of many toxin families. Among these, phospholipase A2 (PLA2) constitute a prime example as they are ubiquitous...