Mechanistic Insights into NOBA Hydrolysis by Viper Venom Secreted Phospholipase A2 [0.03%]
从短尾赤蛇毒液中分离到的分泌型卵磷脂酶A₂对NOBA水解的机理研究
Ana Rita Calixto,Roberto Pinto,Maciej Spiegel et al.
Ana Rita Calixto et al.
Snake envenoming remains a major global health challenge, particularly in tropical and subtropical regions. Among the key toxic components of snake venom, secreted phospholipases A2 (sPLA2) play a crucial role by hydrolysing cell membrane p...
The CYP134 Family in Gram-Positive Bacteria: From Bacillus to Beyond, an Orphan P450 Lineage Awaiting Functional Discovery [0.03%]
革兰氏阳性菌中的CYP134家族：从芽孢杆菌到更广阔的世界，一个等待功能发现的孤儿P450谱系
Yiru Wang,Ying Li
Yiru Wang
Cytochrome P450 monooxygenases (CYPs) are pivotal enzymes in microbial metabolism, catalyzing a broad spectrum of oxidative reactions with ecological, physiological, and biotechnological significance. Within this superfamily, numerous Bacil...
Both single mutation and molecular conjugation on the mutant prevent calcitonin from forming amyloid fibrils [0.03%]
单点突变和分子交联均可阻止降钙素形成淀粉样纤维
Chia-Chi Chang,Govindan Sivakumar,Meng-Chieh Huang et al.
Chia-Chi Chang et al.
Human calcitonin (hCT) is a peptide hormone made up of 32 amino acids, produced by the parafollicular cells of the thyroid gland. Its main role is to decrease blood calcium levels by inhibiting osteoclast activity and reducing calcium reabs...
A Trichomonas vaginalis C2-XYPPX-repeat protein with a structured C2 domain displaying dampened flexibility upon binding calcium [0.03%]
一种含有结构化C2结构域的阴道毛滴虫C2-XYPPX重复蛋白在其结合钙离子时表现出灵活性下降
Garry W Buchko,Lijun Liu,Kevin P Battaile et al.
Garry W Buchko et al.
C2 domains are ubiquitous membrane-binding modules of ∼130 residues in eukaryotes that are often associated with proteins involved in membrane trafficking and lipid modification. The genome of Trichomonas vaginalis, the most common, non-vi...
Effects of two longevity interventions, calorie restriction and rapamycin treatment, on the kynurenine-aryl hydrocarbon receptor pathway in aging skeletal muscle [0.03%]
两种增寿干预措施——卡路里限制和雷帕霉素治疗对衰老骨骼肌中的犬尿酸-AhR通路的影响
Mark W Hamrick,Sadanand Fulzele,Carlos M Isales et al.
Mark W Hamrick et al.
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is thought to play important roles in aging, oxidative stress, and cellular senescence. We have previously shown that the AhR agonist kynurenine (Kyn), a tr...
PIMR, a novel Kunitz-type protease inhibitor from the Macrovipera razii, with dual anticoagulant and anticancer activities [0.03%]
一种新型的血栓和癌症双作用矛头沙漠沙蛇Kunitz型蛋白酶抑制剂PIMR
Pegah Moshtaghian,Hoda Ayat,Ali Mohammad Ahadi et al.
Pegah Moshtaghian et al.
Snake venom is a rich source of bioactive peptides with diverse pharmacological effects. Kunitz-type protease inhibitors are one of the multifunctional peptides isolated from the snake venom. The Razi's viper, Macrovipera razii, is a specie...
Exercise-Driven Changes in Tryptophan Metabolism Leading to Healthy Aging [0.03%]
运动诱导的色氨酸代谢变化促进健康老龄化
Diana M Asante,Sagar Vyavahare,Mansi Shukla et al.
Diana M Asante et al.
Tryptophan metabolism is a critical regulator of physiological and pathological processes, primarily through the kynurenine (KYN), serotonin and indole pathways. Dysregulation of indoleamine 2,3-dioxygenase 1 (IDO1) activity, serotonin and ...
Sodium benzoate, a common food preservative-induced Insulin resistance and atrophy in C2C12 myotubes [0.03%]
钠苯甲酸诱导的C2C12肌管细胞胰岛素抵抗及肌萎缩现象的研究
Onkar Sharma,Anita Dua,Sanjeev Gupta et al.
Onkar Sharma et al.
Sodium benzoate (SB), a widely used food preservative, has been reported to possess several therapeutic benefits including treating neurodegenerative disorders as well as negative effects such as altering glucose homeostasis. However, limit...
Effects of N-linked glycans on the activity and stability of Atragin and K-like from Naja atra [0.03%]
黑曼BACKMAN阿加林和K-样多肽N-连接糖链对其活性及稳定性的影响
Han Ba Bui,Duc Phu Phan,Wen-Guey Wu
Han Ba Bui
Atragin and K-like are N-linked glycoproteins that belong to the P-III class of snake venom metalloproteinases, which hydrolyze components of the extracellular matrix and plasma proteins, thus contributing to vascular damage and coagulation...
Long photoperiod induces porphyrin accumulation while maintaining lipid peroxidation stability in Harderian glands of female striped dwarf hamsters [0.03%]
长时间光照诱导条纹侏小鼠Harderian腺血红素积累而保持类脂过氧化稳定性
Lu-Fan Li,Yi-Man Liu,Yu-Jing Yan et al.
Lu-Fan Li et al.
Photoperiodic regulation exerts a significant influence on growth and development in seasonal mammals, yet its impact on oxidative stress and ferroptotic signaling in the Harderian glands of striped dwarf hamsters (Cricetulus barabensis) re...