ANGPTL4 Regulates the Adipogenic-Osteogenic Differentiation Balance of Bone Marrow Mesenchymal Stem Cells: A Novel Mechanism of Osteoporosis from the Perspective of Lipid Metabolism [0.03%]
血管生成素样蛋白4通过调节脂质代谢调控骨髓间充质干细胞成脂/成骨分化平衡：一个新的骨质疏松症发病机制理论
Fuhao Huang,Zhu Zhu,Qiqiang Xing et al.
Fuhao Huang et al.
To investigate the role of lipid metabolism abnormalities in the progression of osteoporosis (OP), clarify the impact of the key regulator angiopoietin-like protein 4 (ANGPTL4) on the adipogenic-osteogenic differentiation balance of bone ma...
The Aryl Hydrocarbon Receptor: A Modulator of Skeletal Muscle Health and Aging [0.03%]
aryl烃受体：骨骼肌健康和衰老的调节因子
Keon Wimberly,Terence E Ryan
Keon Wimberly
Skeletal muscle is fundamental to human health, serving as the primary effector of movement and a central regulator of systemic metabolism. Age-related declines in muscle mass and mitochondrial function contribute to frailty, metabolic dysf...
The antiretroviral drug emtricitabine increases kynurenine: tryptophan ratio, aryl hydrocarbon receptor activation, and cellular senescence in female mice [0.03%]
抗逆转录病毒药物恩曲他滨增加雌性小鼠的犬尿氨酸:色氨酸比率，芳烃受体激活和细胞衰老
Alok Tripathi,Shabiha Sultana,Sagar Vyavahare et al.
Alok Tripathi et al.
HIV-associated mortality has been reduced by antiretroviral therapies (ART), but prolonged ART usage by people living with HIV (PLWH) is associated with frailty and poor healthspan. Mechanisms driving this phenomenon are not fully known, bu...
Extracellular mitochondria: a potential player involved in exercise health benefits [0.03%]
细胞外线粒体：运动有益健康的潜在机制
Mafalda Barbosa Pedrosa,Lúcio Lara Santos,Rita Ferreira et al.
Mafalda Barbosa Pedrosa et al.
Exercise is widely recognized as an effective nonpharmacological therapy for noncommunicable diseases, with its health benefits mediated in part by exerkines. Recently, extracellular mitochondria (ex-Mito) have been suggested as a player in...
Giardia duodenalis: Base excision repair pathway enzyme FEN1 carries out catalytic activities pertaining to NER pathway [0.03%]
杜氏利什曼原虫DUODENALIS：基于切除修复途径的酶FEN1执行着与NER途径相关的催化活性
Ulises Omar García-Lepe,Sofía Gabriela Tomás-Morales,María Teresa Izaguirre-Hernández et al.
Ulises Omar García-Lepe et al.
Giardia duodenalis is a binuclear protozoan that causes intestinal infection in humans and animals. The life cycle of G. duodenalis is comprised by 2 stages: trophozoite (vegetative, ploidy: 4N) and cyst (infective, ploidy: 8-16N) and the t...
Functional Characterization of Cr-CATHs: Novel Antimicrobial Peptides from the Coastal Bird Chroicocephalus ridibundus [0.03%]
来自海岸鸟Chroicocephalus ridibundus的新型抗菌肽Cr-CATHs的功能表征
Haoran Dou,Shuangyu Li,Pingchuan Zhang et al.
Haoran Dou et al.
The escalating global threat of antimicrobial resistance (AMR) and chronic biofilm-associated infections underscores the urgent need for novel therapeutic agents. Antimicrobial peptides (AMPs) offer a promising alternative due to their pote...
Inhibiting catalytic activity of Plasmodium falciparum aspartate protease Plasmepsin V: A biochemical approach to malaria intervention [0.03%]
抑制疟原虫天冬氨酸蛋白酶Plasmepsin V的催化活性：一种生化干预方法
Anitadevi K Prajapati,Yogesh Kumar,Sinjan Choudhary
Anitadevi K Prajapati
Plasmepsin V, an aspartate protease, is crucial for the survival of the malarial parasite Plasmodium falciparum, making it a promising target for antimalarial drug development. In this study, the quinoline-based drugs amodiaquine (AQ) and c...
Lmod3 ablation disrupts auditory function without compromising hair cell stereocilia development or MET competence [0.03%]
Lmod3基因敲除小鼠听觉功能受损但毛细胞立体纤毛发育及机械门控通道功能正常
Haibo Du,Xi Huang,Sun Yixiao et al.
Haibo Du et al.
F-actin cytoskeleton plays critical roles in hair cell. This study identifies LMOD3, an F-actin nucleator, as specifically expressed in outer hair cells (OHCs) of mice. Lmod3 knockout causes significant hearing loss (about 40 dB elevation i...
A comprehensive review on the Advanced Glycation End Products detection: From conventional to advanced approaches [0.03%]
AGEs检测方法的研究进展：从传统到先进
Subhrajeet Sahoo,Michael Howsam,Frédéric J Tessier et al.
Subhrajeet Sahoo et al.
The glycation process ultimately generates advanced glycation end products (AGEs) either exogenously or endogenously. With unique structural and functional properties, AGEs contribute to diabetic complications and other glycation-mediated d...
The uptake of ingested vitamin B12 and its total body balance: a mathematical model suggests the optimal supplementation strategy [0.03%]
口服维生素B12的吸收及其总体平衡：数学模型建议最佳补充策略
Sergey N Fedosov
Sergey N Fedosov
Impaired or insufficient uptake of vitamin B12 causes neurological disorders, anemia, and various diffuse symptoms, all historically called pernicious anemia (PA). Maintenance of adequate B12 body store (B) is important, but the recommended...