Hesperetin induces Mitochondria Independent Apoptosis-Like Death in Candida albicans [0.03%]
hesperetin诱导Candida albicans独立于线粒体的类似凋亡的细胞死亡
Huiwon Jang,Dong Gun Lee
Huiwon Jang
Hesperetin, a flavonoid abundantly found in citrus fruits, exhibits broad-spectrum antimicrobial activity and has been proposed as a potential alternative to conventional antifungal agents. However, its precise mode of action(s), particular...
Leptin Increases Lipid Storage in Sertoli Cells: Signaling Pathways and Cellular Mechanisms Involved [0.03%]
瘦素通过相关信号通路和细胞机制增加支持细胞的脂质储存
Marina Ercilia Dasso,Cecilia Lucia Centola,Florencia Nerea Tabares et al.
Marina Ercilia Dasso et al.
Leptin is an adipokine with a role in male reproductive function. Sertoli cells (SCs) express leptin receptors, but leptin effects on SCs' functions have been scarcely researched. SCs support germ cell development by providing various compo...
Hongwei Zhao,Chao Huang
Hongwei Zhao
Therapeutic resistance is a major obstacle in cancer treatment, often leading to recurrence and death. SUMOylation is a dynamic and reversible process of post-translational modification through a strict enzyme cascade that regulates the mod...
Relationship between structure and function of the NADH oxidase from Lactobacillus brevis [0.03%]
乳酸片球菌NADH氧化酶的结构和功能的关系研究
Mathieu Dondelinger,Marylène S Vandevenne,Frédéric Kerff et al.
Mathieu Dondelinger et al.
Water-producing NADH oxidases catalyse the oxidation of NADH by molecular oxygen to generate NAD+ and water. These enzymes require FAD as cofactor to carry out their enzymatic activity and contribute to bacterial protection against oxidativ...
Alisa P Chernyshova,Petr V Sergiev,Dmitrii A Lukianov et al.
Alisa P Chernyshova et al.
Antimicrobial resistance threatens the long-standing efficacy of antibiotics and underscores the need to expand, refine, and diversify antimicrobial therapies. Translation is a uniquely druggable process: its machinery is essential, conserv...
Deepti Jamwal,Prince Kumar,Kunal Meena et al.
Deepti Jamwal et al.
CELA3A and CELA3B are the primary elastases secreted by the human pancreas that are digestive enzymes and are markers for pancreatic exocrine insufficiency. CELA1, another family member, is not expressed in the human pancreas but has been d...
Human mitochondrial persulfide dioxygenase is potently and reversibly inhibited by nitric oxide [0.03%]
人类线粒体多硫化物二氧还酶被一氧化氮有效地可逆抑制
Francesca Giordano,Diogo H P Silva,Elena Forte et al.
Francesca Giordano et al.
Hydrogen sulfide (H2S) regulates multiple human physiological processes, its reactivity and range of action being tightly controlled through regulation of H2S-synthesizing and -detoxifying enzymes. H2S detoxification is mainly achieved by a...
Dietary modulation of purine metabolism and uric acid homeostasis in cancer patients with an ileostomy [0.03%]
饮食调节嘌呤代谢和尿酸在家造瘘癌患者体内的平衡
Kamil Aleksander Sobieszek,Jakub Frankowski,Mateusz Labudda
Kamil Aleksander Sobieszek
Nutritional management in cancer patients with an ileostomy poses specific challenges due to impaired nutrient absorption, elevated metabolic demands, and the need to control serum urate levels. This review examines the biochemical and clin...
Phase separation in regulation of gene expression: current methodological and conceptual approaches [0.03%]
基因表达调控中的相分离：当前的方法和概念 접근方式
Kalina Wegrzyn,Tomasz Wilanowski
Kalina Wegrzyn
Phase separation underlies the formation of subcellular structures known as biomolecular condensates or membraneless organelles. In the last 15 years, a great effort has been made to characterize the biophysical properties of condensates an...
Functional and immunological variability of Viperid venoms across continents and cross-neutralization by Peruvian antivenoms [0.03%]
美洲和亚洲蝰蛇毒素的功能和免疫学差异以及秘鲁抗蛇毒血清的交叉中和效果
Daniel Torrejón,Alexander Llontop,Alex Proléon et al.
Daniel Torrejón et al.
Snake envenomation remains a significant neglected tropical disease primarily treated with antivenoms, which, despite inherent limitations, continue to be the gold standard therapy. Snake venoms exhibit extensive compositional and functiona...