Label-free quantitative shotgun analysis of bis(monoacylglycero)phosphate lipids [0.03%]
无标签定量蛋白质组分析甘油二酯磷酸单酰基甘油磷脂分子动力学变化
Lian Y Wang,Rico J E Derks,Kevin A J Brewster et al.
Lian Y Wang et al.
Interest in the role of bis(monoacylglycero)phosphate (BMP) lipids in lysosomal function has significantly grown in recent years. Emerging evidence highlights BMPs as critical players not only in Niemann-Pick disease type C (NPC) but also i...
Comprehensive and high-coverage glycerophospholipidomic analysis based on iterative quadrupole time-of-flight mass spectrometry and its application in cerebral ischemia-reperfusion injury [0.03%]
基于四极杆飞行时间质谱迭代分析的全面高覆盖磷脂组学研究及其在脑缺血再灌注损伤中的应用
Biqiong Qu,Menghan Feng,Lirong Liu et al.
Biqiong Qu et al.
Glycerophospholipids play important roles in iron-induced lipid peroxidation during cerebral ischemia-reperfusion, making it essential to investigate changes in their varieties and concentrations under these conditions. However, the wide ra...
Dispersive solid-phase extraction as sample pretreatment for determination of chemotherapeutic agents revumenib and venetoclax by HPLC-DAD [0.03%]
基于HPLC-DAD测定瑞美木班和维奈克拉的样品前处理分散固相萃取法
Sergio Fernández-Trujillo,Gregorio Castañeda-Peñalvo,Juana Rodríguez-Flores et al.
Sergio Fernández-Trujillo et al.
The first nanotechnology-based innovative analytical strategy by means of dispersive solid-phase extraction (DSPE) as a necessary sample treatment approach for the simultaneous determination of revumenib and venetoclax in complex biological...
Evaluating inkjet dispenser/liquid vortex capture-mass spectrometry for single-cell metabolomics in Hep G2 steatosis caused by tamoxifen [0.03%]
评估喷墨分配器/液旋捕集-质谱在托美溴胺诱导的Hep G2泡沫化细胞单细胞代谢组学中的应用
Stephen C Zambrzycki,Vilmos Kertesz,John F Cahill
Stephen C Zambrzycki
Single-cell mass spectrometry (MS) is advancing our understanding of metabolic pathways in heterogeneous cell populations; however, many techniques are slow or require disruptive sample preparations. This study evaluated coupling a modified...
Development and analysis of 49 perfluoroalkyl and polyfluoroalkyl substances (PFASs) in contact lenses using liquid chromatography-tandem mass spectrometry (LC-MS/MS) [0.03%]
采用液相色谱-串联质谱法（LC-MS/MS）分析软性隐形眼镜中49种含氟化合物(PFASs)的方法建立及应用分析
Yi-Chun Chiang,Chuan-Kai Yang,Sheng-Wei Wang et al.
Yi-Chun Chiang et al.
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) possess water-repellent, oil-repellent, and heat-resistant properties, making them widely used in consumer goods and industrial products. However, PFASs have been increasingly associated...
pH-tuned reversible self-assembly of Janus particles for enhanced Raman imaging and sensing [0.03%]
用于增强拉曼成像和检测的pH控制的Janus颗粒可逆自组装
Maria Iftesum,Mohan Kumar Dey,Alisha Prasad et al.
Maria Iftesum et al.
The controlled self-assembly of Janus particles via pH modulation offers an effective strategy for optimizing surface-enhanced Raman scattering (SERS) and Raman signal amplification. These asymmetric microparticles enable precise spatial or...
A homogeneous immunoassay technology based on liposomes and the complement system enables one-step, no-wash, rapid diagnostics directly in serum [0.03%]
一种基于脂质体和补体系统的均相免疫测定技术可实现一步法、无需洗涤的快速诊断直接在血清中进行
Kilian Hoecherl,Simon Streif,Clemens Spitzenberg et al.
Kilian Hoecherl et al.
Liposomes are a well-established carrier and controlled release system in medicine and bioanalysis. Their biomimetic capabilities are harnessed for the development of a reliable homogeneous assay platform technology that lends itself to hig...
UHPLC-QTOF-MS-based metabolomics joint high-throughput RNA sequencing transcriptomics approach for the analysis of fecal and liver biological samples and application in a case study for the mechanism of Qing-Kai-Ling oral liquid in treating MASLD [0.03%]
基于UHPLC-QTOF-MS代谢组学与高通量RNA测序转录组学的粪便和肝脏生物样本分析方法及其在清凯灵口服液治疗MASLD机制研究中的应用
Kaiwei Cai,Zihao Chen,Jingyun Wu et al.
Kaiwei Cai et al.
Qing-Kai-Ling (QKL) oral liquid has been increasingly used in metabolic dysfunction-associated steatotic liver disease (MASLD). However, the specific metabolic differentials and metabolic pathway mechanisms that affect the MASLD regulated b...
Structural and functional optimization of COF-coated stirring bars for environmental monitoring and biological sample analysis [0.03%]
用于环境监测和生物样品分析的涂有COF的搅拌棒的结构与功能优化
Lianzhi Wang,Xixi Lian,Jianing Sun et al.
Lianzhi Wang et al.
In this study, a series of covalent organic framework (COF)-coated stirring bars-COF-a, COF-b, and COF-c-were innovatively designed and evaluated for the efficient extraction of estrogens from complex environmental and biological samples. T...
Efficient and sustainable recovery of bioactive compounds from cashew nut testa shell (Anacardium occidentale L.) using pressurized liquid extraction [0.03%]
高效且可持续地从现金果皮壳（Anacardium occidentale L.）中利用加压液体萃取法回收生物活性化合物
Jonas da Silva,Anderson Felipe Viana da Silva,Karina Cesca et al.
Jonas da Silva et al.
Cashew nut processing generates large quantities of byproducts daily, such as cashew nut testa shell (CNTS), which is discarded, leading to environmental and economic issues. However, CNTS contains bioactive substances such as polyphenols a...