Revisiting single-cell migration parameters from 2D video microscopic measurements [0.03%]
基于二维视频显微测量的单细胞迁移参数再研究
Gréta Bányai,Márton Bese Naszlady,János Juhász et al.
Gréta Bányai et al.
Video microscopy-based single-cell migration analysis allows for precise measurement of cell migration by extracting a range of migration parameters from tracking data during analysis. This study aimed to enhance our understanding of the be...
Vimentin in the tumor microenvironment: orchestrating invasion, immunity, and metabolism [0.03%]
肿瘤微环境中波形蛋白：协调侵袭、免疫和代谢功能
Sepideh Parvanian,John E Eriksson
Sepideh Parvanian
Vimentin, a type III intermediate filament protein, has gained recognition as a multifunctional regulator within the tumor microenvironment (TME). While traditionally considered a hallmark of epithelial-to-mesenchymal transition (EMT), vime...
Consequences of plectin ablation on the various intermediate filament systems in skeletal muscle [0.03%]
plectin缺失对骨骼肌各种中间纤维系统的影响
Marta Rocha,Jonas Petsch,Dorothea Schultheis et al.
Marta Rocha et al.
Plectin, a highly versatile and multifunctional cytolinker, acts as a central connector of the intermediate filament (IF) and other cytoskeletal systems. In skeletal muscle, plectin orchestrates and anchors the extrasarcomeric desmin filame...
Deciphering the landscape of post-translational modifications in the centrosome upon T cell activation [0.03%]
T细胞活化过程中中心体蛋白翻译后修饰的图谱解析
Marta Lozano-Prieto,Inmaculada Jorge,Emilio Camafeita et al.
Marta Lozano-Prieto et al.
The shift from quiescent to effector T cells (TC) is controlled at the translational level. Post-translational modifications (PTMs) are key factors in the diversification of protein function. Advancements in mass spectrometry-based proteomi...
Human diamine oxidase undergoes transcytosis and colocalizes with the plasma membrane monoamine transporter indicating intracellular histamine degradation [0.03%]
人二胺氧化酶发生穿越胞吞作用并同时存在于血浆单胺转运蛋白中的迹象表明组胺在细胞内被降解
Elisabeth Gludovacz,Grace Wen,Matthias Weiss-Tessbach et al.
Elisabeth Gludovacz et al.
Secreted human diamine oxidase (hDAO) is the only enzyme capable of extracellular histamine inactivation. Histamine is the key mediator released at high concentrations from activated mast cells causing various unpleasant to life-threatening...
Structure and function of the keratin 17 tail domain associated with keratin intermediate filament organization [0.03%]
角蛋白17尾结构域与角蛋白中间丝组织的结构和功能关系研究
Jiwoo Yeom,Sanghoon Lee,Young Ho Ko et al.
Jiwoo Yeom et al.
Keratins are the largest subgroup of intermediate filament proteins, forming 10-nm filaments from type I/II heterodimers, and occur primarily in epithelial cells. Keratin 6 (K6; type II) and Keratin 17 (K17; type I) show a complex expressio...
PSTPIP1 and pyrin, two key regulators of macrophage differentiation [0.03%]
PSTPIP1和pyrin——调控巨噬细胞分化的两个关键因子
Philipp Berger,Lisa Wilming,Ricarda Jürgens et al.
Philipp Berger et al.
Background: Monocytes develop from hematopoietic stem cells; migrate into the tissue, where they undergo a stimulation-dependent and tissue specific differentiation into macrophages imprinting specific inflammatory functi...
A physiologically relevant blood-cerebrospinal fluid barrier model to study the permeability of neurodegenerative biomarkers [0.03%]
一种用于研究神经退行性生物标志物通透性的生理相关血液脑脊液屏障模型
Petra Majerova,Krutika Khiratkar,Michaela Skrabanova et al.
Petra Majerova et al.
The blood-cerebrospinal fluid barrier (BCSFB) is formed by the choroid plexus and represents the interface between the blood and cerebrospinal fluid (CSF). Several in vitro models have been developed to establish an active cellular barrier ...
The cortical actin cytoskeleton and desmosomes act together in keratin filament network maintenance [0.03%]
皮层肌动蛋白细胞骨架和桥粒共同作用维持角蛋白丝网络
Nicole Schwarz,Sebastian Kant,Rudolf E Leube
Nicole Schwarz
Keratin intermediate filaments are hallmark features of epithelial tissue differentiation forming complex cytoplasmic networks that are connected to subplasmalemmal cortical keratin filaments and anchored at desmosomal junctions. The mechan...
Myosins 1e/f at the podosome base regulate podosome dynamics and promote macrophage migration [0.03%]
肌球蛋白1e/f调控足突动态并促进巨噬细胞迁移
Pasquale Cervero,Sarah R Barger,Perrine Verdys et al.
Pasquale Cervero et al.
Cells of the monocyte lineage form specialized membrane-associated, actin-rich structures, called podosomes. Podosomes play important roles in cell adhesion and migration as well as the proteolytic degradation of the extracellular matrix. W...