Diammonium glycyrrhizinate alleviates iron overload-induced liver injury in mice via regulating the gut-liver axis [0.03%]
甘草酸二铵通过调节肠肝轴缓解铁过载诱导的小鼠肝损伤
Yu Liu,Xiaohong Li,Ziwei Guo et al.
Yu Liu et al.
Background: Evidence indicates a close association between iron overload (IO) and the pathogenesis of chronic liver diseases, highlighting the potential for interventions targeted at IO to impede or decelerate the progres...
Damascenone inhibits osteoclastogenesis by epigenetically modulating Nrf2-mediated ROS scavenge and counteracts OVX-induced osteoporosis [0.03%]
damascenone通过表观遗传调控Nrf2介导的ROS清除抑制破骨细胞生成并对抗卵巢切除术引起的骨质疏松症
Qingliang Ma,Yinuo Xiong,Zhiwei Jie et al.
Qingliang Ma et al.
Background: Bone formation and resorption regulate bone homeostasis. Excessive osteoclastogenesis enhances bone resorption and causes osteoporosis. Although medicines targeting osteoclast have been developed, these drugs ...
Gastrodin reduces Aβ brain levels in an Alzheimer's disease mouse model by inhibiting P-glycoprotein ubiquitination [0.03%]
姜半红素通过抑制P-糖蛋白泛素化降低阿尔茨海默病模型小鼠脑内Aβ水平
Chenghao Zhu,Shangtao Wang,Siyu Ma et al.
Chenghao Zhu et al.
Background: Studies have demonstrated the potential of gastrodin in the treatment of Alzheimer's disease (AD), however, its mechanism of action remains elusive. Currently, the Amyloid-β (Aβ) cascade hypothesis continues...
Disruption of local circadian clocks in aristolochic acid-induced nephropathy in mice [0.03%]
马兜铃酸肾病小鼠局部昼夜钟扰乱现象的研究
Dihao Xie,Simin Zhong,Meixue Luo et al.
Dihao Xie et al.
Background: Aristolochic acid I (AAI), an emerging biogenic contaminant widely present in Aristolochic plants, has been implicated in the progression of tubulointerstitial disease, known as aristolochic acid nephropathy (...
The inhibition of rutin on Src kinase blocks high glucose-induced EGFR/ERK transactivation in diabetic nephropathy by integrative approach of network pharmacology and experimental verification [0.03%]
网络药理学和实验验证整合方法研究芦丁通过抑制Src激酶阻断高糖诱导的EGFR/ERK信号串激活在糖尿病肾病中的作用
Liang Wu,Luqian Li,Xue Wang et al.
Liang Wu et al.
Background: Although clinical strategies for diabetic nephropathy (DN) therapy include stringent blood pressure control through blockade of the renin-angiotensin system and management of hyperglycemia, the condition is st...
Jia Wei Qingxin Lotus Seed Drink ameliorates epithelial mesenchymal transition injury in diabetic kidney disease via inhibition of JMJD1C/SP1/ZEB1 signaling pathway [0.03%]
加味清心莲子饮通过抑制JMJD1C/SP1/ZEB1信号通路改善糖尿病肾病上皮间质转化损伤
Jiarun Xie,Haoyu Lin,Fuhua Jin et al.
Jiarun Xie et al.
Background: Diabetic kidney disease (DKD) is one of the most common microvascular complications in patients with diabetes mellitus. In this condition, renal tubular epithelial mesenchymal transition (EMT) is an important ...
Ameliorative effect and underlying mechanism of the Xiaxue Kaiqiao formula on age-related dementia in Samp8 mice [0.03%]
补肾开窍方对SAMP8型老年痴呆小鼠的改善作用及机制研究
Lu Dai,Xiaoxu Wang,Meng Li et al.
Lu Dai et al.
Background: Dementia, a major symptom of several neurodegenerative diseases, can be improved by acetylcholinesterase inhibitors (AChE); however, due to the complex etiology and long course of dementia, the efficacy of the...
Pharmacological mechanisms of traditional Chinese medicine against acute lung injury: From active ingredients to herbal formulae [0.03%]
基于活性单体与方剂的中医药治疗急性肺损伤药理机制研究进展
Yamin Liu,Xunjiang Wang,Yilin Chen et al.
Yamin Liu et al.
Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the leading causes of acute respiratory failure in many critical diseases and are among the main respiratory diseases with high clinic...
Integrated gut microbiome and UHPLC-MS metabolomics to reveal the prevention mechanism of pidanjiangtang granules on IGT Rats [0.03%]
整合肠道微生物组和UHPLC-MS代谢组学研究pidan姜黄颗粒干预IGT大鼠的作用机制
Yu Xie,Zirong Li,Yue Fan et al.
Yu Xie et al.
Introduction: Pidanjiangtang (PDJT) is a traditional Chinese medicine formula empirically used to treat impaired glucose tolerance (IGT) based on the "Pidan" theory from the classic ancient book Nei Jing. However, the mec...
Lutein, a versatile carotenoid: Insight on neuroprotective potential and recent advances [0.03%]
多功能类胡萝卜素叶黄素：神经保护潜力及最新进展的见解
Megha Jayakanthan,Janani Manochkumar,Thomas Efferth et al.
Megha Jayakanthan et al.
Background: Neurodegenerative diseases (NDDs) are a diverse group of neurological disorders with progressive neuronal loss at specific brain regions, leading to impaired cognitive functioning, loss of neuroplasticity, sev...